Cayman Chemical

A full antagonist of estrogen ERβ receptors with 36-fold selectivity over ERα (relative binding affinities are 0.01 and 0.36, respectively); enhances SKOV3 and OV2008 ovarian cancer cell growth in in vitro assays at 100 pM.

An I_Ks and I_CTFR blocker.

A model nucleobase that is used to study DNA interactions with organometallic complexes, especially those designed to target tumors.

A broad spectrum inhibitor of MMPs, with IC₅₀ values of 1-5 nM for all MMPs tested, including MMP-1, -2, -3, -7, -9, -13, and -14; also potently inhibits TACE (IC₅₀ = 14.9 nM); has anti-proliferative, anti-invasive, and anti-metastatic actions that are relevant, in particular,...

Antigen: recombinant rabbit TPH Host: sheep Cross Reactivity: (+) human and rat TPH; expected to react with other mammals; (−) rabbit TPH Applications: WB and IHC (frozen sections)

A mixture of the potent and selective CB1 receptor antagonist SLV 319 (Ki = 7.8 nM) and its distomer, SLV 319 (+)-enantiomer.

15-deoxy-Δ12,14-Prostaglandin J2 (15-deoxy-Δ12,14-PGJ2; Item No. 18570) is one of the cyclopentenone PGs, which have documented metabolic (peroxisome proliferator-activated receptor γ-activating), antimitotic, and antiproliferative effects. The activity of the compounds in this...

Antigen: human full length p38 MAPK Host: mouse, clone 9F12 Cross Reactivity: (+) human, mouse, and rat p38 MAPK Application(s): FC, ICC, and WB p38 MAPK is a member of the serine-threonine MAPK family that triggers many cellular processes including cell cycle, development, and apoptosis.

An indolocarbazole antibiotic produced by S. aerocolonigenes ATCC39243 that weakly inhibits DNA topoisomerase I; cytotoxic to human lung adenocarcinoma, colon carcinoma, and nasopharyngeal carcinoma cell lines (IC₅₀s range from 0.4-98 µM).

A potent, selective inhibitor of ERK1 and ERK2 (IC₅₀s = 4 and 1 nM, respectively); has nanomolar cytotoxicity in tumor cells with mutations in BRAF, NRAS, or KRAS; effective in vivo, inducing regression of xenograft tumors in mice.

A tetrasialoganglioside that promotes neurite outgrowth during early neuronal differentiation via ERK1/2 MAP kinase pathway activaton; also initiates keratinocyte differentiation.

An Oct4-activating compound which activates expression through the Oct4 gene promoter; at 1 μM, enhances reprogramming efficiency by increasing the rate of production of induced pluripotent stem cells from embryonic fibroblasts expressing Oct4 with Sox2, Klf4, and c-Myc.

A natural flavonol glycoside with iron chelating and antioxidant properties; demonstrates anti-inflammatory, anti-cancer, anti-fibrosis effects as well as hepato- and neuroprotective actions in animal models.

Active metabolite of molsidomine that acts as a potent vasorelaxant and inhibitor of platelet aggregation; produces both NO and superoxide to generate peroxynitrite under physiological conditions.

An isoprenoid antibiotic and antiviral that suppresses PMA-induced invasion in renal carcinoma cells (IC₅₀ = ~10 µM) by inhibiting the expression of MMP-9; profoundly increases the expression of p53 by increasing protein stability in cancer cells and inhibits signaling through...

Antigen: human CB1 receptor amino acids 461-472 Host: rabbit Cross Reactivity: (+) human, mouse, and rat CB1 receptor Application(s): IHC (parrafin-embedded tissue) and WB This antibody has been raised against the C-terminal (amino acids 461-472) intracellular region of the human CB1 receptor, a...

An irreversible, membrane-permeable inhibitor of lysosomal and cytosolic cysteine proteases; at 20-200 µM arrests human epidermoid carcinoma A431 cells at mitotic metaphase; inhibits protease-resistant protein accumulation in scrapie-infected neuroblastoma cells (IC₅₀ = 0.5...

PGF2α is one of the five primary PGs derived enzymatically directly from the endoperoxide PGH2. The majority of the functional roles ascribed to it relate to fertility, pregnancy, and parturition. Like all of the primary PGs, PGF2α has a very short half-life in the general circulation....

A selective, ATP-competitive, pan-Akt inhibitor that targets Akt1, 2, and 3 (IC₅₀s = 5, 18, and 8 nM, respectivley); blocks Akt signaling both in cultured tumor cell lines and tumor xenograft models.

An internal standard for the quantification of arachidonic acid by GC- or LC-MS.

A synthetic peptide that that selectively, reversibly, and substrate-competitively inhibits PKCζ activity and, thus, is used to delineate the signaling functions of PKCζ.

DL-Homocystine is an oxidized dimeric form of homocysteine (Item No. 30285). It inhibits CDNB-induced L-cystine (Item No. 31727) transport into isolated human erythrocytes by 75% when used at a concentration of 2.5 mM.{67034} DL-Homocystine increases the number of circulating endothelial cells and...

An affinity probe which allows carbaprostacyclin to be detected in complexes with transmembrane receptors and/or nucleic or protein binding partners.

A selective, nonpeptide antagonist of the vasopressin V1a receptor (Ki = 1.1-6.3 nM in human); inhibits arginine vasopressin-induced human platelet aggregation with an IC₅₀ value of 3.7 nM.