DL-Homocystine

DL-Homocystine is an oxidized dimeric form of homocysteine (Item No. 30285). It inhibits CDNB-induced L-cystine (Item No. 31727) transport into isolated human erythrocytes by 75% when used at a concentration of 2.5 mM.{67034} DL-Homocystine increases the number of circulating endothelial cells and permeability of the pulmonary microcirculation and decreases the number of circulating platelets, as well as activates venostatic thrombosis induced by bowel loop ligation in a rat model of homocystinemia, an inborn error of metabolism characterized by a deficiency in cystathionine ß-synthase (CBS) that is associated with thrombosis and atherosclerosis.{67035}