Cayman Chemical

Antigen: peroxynitrite-treated KLH Host: mouse Isotype: IgG2b Application(s): EIA, IHC, IP, and WB The presence of nitrotyrosine on proteins can be used as a marker for peroxynitrite formation in vivo. Nitrotyrosine has been shown to be present in proteins from a variety of clinical conditions...

A broad-spectrum antibiotic that inhibits protein synthesis by inducing miscoding; commonly used as a dominant selection antibiotic for genetically modified bacteria, yeasts, fungi, protozoa, plants, and mammalian cells.

A urinary metabolite of sulfamethoxazole, an antibiotic with antiviral activity.

CAS: 84692-91-1

A cell-permeable inhibitor of the PPIases Pin1 and Pin4 (IC₅₀s = 1.5 and 1.0 µM, respectively), interacting with the PPIase domain; blocks the proliferation of cancer cells that overexpress Pin1 and Pin4 (IC₅₀ range = 2-5 µM), and similarly inhibits wild MEFs but...

3-thia TDA is an analog of the 14-carbon saturated fatty acid myristic acid, wherein the C-3 carbon has been replaced by sulfur in a thioether linkage. When chronically administered to rats, 3-thia TDA acts as a peroxisome inducer (PPAR ligand), increases fatty acid oxidation, and lowers plasma...

A nonhydrolyzable GTP analog that binds to and irreversibly activates G proteins; potently stimulates adenylate cyclase.

A cell-permeable chemical probe that reacts specifically with sulfenic acid-modified proteins; azido group of DAz-2 provides a method for the selective conjugation to phosphine- or alkynyl-derivatized reagents, such as biotin or various fluorophores, for subsequent analysis of the labeled proteins.

Cayman’s Glucose Assay provides a simple, reproducible, and sensitive tool for assaying glucose in plasma, serum, and urine. The glucose assay uses the glucose oxidase-peroxide reaction for the determination of glucose concentrations. In this assay, glucose is oxidized to d-gluconolactone with...

A phenylpropanoid which readily co-crystallizes with various biomolecules.

A lipophilic activator of PKA and PKG (Ka = 0.05 and 0.11 μM, respectively); inhibits PDE VA, PDE III, and PDE IV with IC50 values of 0.9, 24, and 25 μM, respectively.

11-KT is a second key androgenic steroid found in fish. It occurs in males together with testosterone in amounts which vary from less than 1 ng/ml to as much as 50-100 ng/ml, depending on the species and the stage of the reproductive cycle.

A fungal steroid that demonstrates phytotoxic activity and is reported to inhibit PI3K.

A potent inhibitor of iNOS with a Ki value of 47 nM (Ki values for eNOS and nNOS are 9 and 25 µM, respectively).

A precursor of rhein, which inhibits IL-1β signaling at 10 µM, suppresses signaling through NF-κB and AP-1, and reduces the expression of MMP-1 and MMP-13; down-regulates the expression of the IL-1β receptor, enhances the expression of TGF-β, and increases collagen and...

A potent cell-permeable antagonist of calmodulin that inhibits Ca2+/calmodulin cyclic nucleotide phosphodiesterase more potently than W-7 (IC₅₀ = 3.2 and 26 µM, respectively).

A specific inhibitor of breast cancer resistance protein (BCRP/ABCG2) multidrug efflux transporter; at 5 μM, significantly potentiates the toxicity of chemotherapeutic drugs in colon carcinoma cells; reverses multidrug resistance in cells overexpressing BCRP but not P-glycoprotein (ABCB1) or MRP1...

9(S)-HODE cholesteryl ester was originally extracted from atherosclerotic lesions. It remains uncertain whether the oxidized fatty acid portion of the molecule results from enzymatic lipoxygenation or from random lipid peroxidation. 9(S)-HODE cholesteryl ester can be used as a standard for analysis...

An inhibitor of HIV-1 protease (EC50 = 2.6 nM); commonly used in vivo in combination therapy for HIV-1 infection.

To be used as a standard for WB and electrophoresis. This enzyme has been carefully purified to exclude all unrelated proteins; may not be catalytically active. COX-1 catalyzes the first step in the biosynthesis of prostaglandins, thromboxanes, and prostacyclins: the conversion of arachidonic acid...

15(S)-HpEDE is a monohydroperoxy PUFA produced by the action of 15-LO on eicosadienoic acid. Although the biological activities of 15(S)-HpEDE have not been well characterized, it is expected to behave similarly to 15(S)-HpETE (Catalog No. 44720).

A purine nucleoside analog that irreversibly inhibits adenosine deaminase (Ki = 0.9 pM) and thus interrupts DNA synthesis in dividing cells; displays strong efficacy in the clinical treatment of hairy cell leukemia as well as relapsed chronic lymphocytic leukemia.

A steroid hormone produced in the body from 5α-reduced metabolites of dehydroepiandrosterone that possesses 7-fold weaker androgen potency compared to that of testosterone; excreted in urine and used as the international reference standard for androgenic activity.

An odoriferous component of musk that has been shown to exhibit anti-inflammatory effects by reducing the expression of proinflammatory cytokines both in vitro and in vivo; also reported to be both cardioprotective and neuroprotective during conditions of ischemia and to promote proliferation and...