Cayman Chemical

A phytoxin that antagonizes chemokine receptor CCR5 binding (IC₅₀ = 40 µM) to the envelop protein gp120 and to CD4, which is known to mediate HIV-1 viral entry into cells; cytotoxic to CLL cells (LC50 = 8 nM).

C-6 NBD ceramide is a biologically active fluorescent analog of short chain, membrane-permeable ceramides. It is as effective as C-6 ceramide in the inhibition of viral glycoprotein transport through the Golgi. C-6 NBD ceramide has been used as a fluorescent substrate for the activity of...

12(S)-HETE-d8 contains eight deuterium atoms at the 5, 6, 8, 9, 11, 12, 14 and 15 positions. It is intended for use as an internal standard for the quantification of 12(S)-HETE by GC- or LC-mass spectrometry (MS).

The 20S proteasome is the proteolytic core of a large protein degradation complex, the 26S proteasome. Proteasome inhibitors exhibit anti-inflammatory and antiproliferative effects, evidence that the proteasome may be an important drug target for the treatment for cancer and inflammatory diseases....

A 7-hydroxy coumarin phase II metabolite that can be used as a standard for the analysis of 7-hydroxy coumarin metabolism.

A mycotoxin produced by Alternaria molds; induces cytochrome P450 1A1 expression and apoptosis in mouse hepatoma cells (20-40 μM).

A high-affinity, lipophilic, non-selective ligand of the β-adrenergic receptors (Kis = 0.114 and 0.4 nM for β2- and β3-adrenoceptors, respectively); acts as a receptor antagonist (beta blocker) or inverse agonist for β1 and β2 receptors but functions as an agonist at the...

A selective blocker of large-conductance Ca2+-activated K+ channels (IC₅₀ = 250 pM) that also acts as an allosteric modulator of charybdotoxin binding (Ki = 250 pM).

An internal standard for the quantification of PGB2 by GC- or LC-MS.

A histamine H1 receptor antagonist (Ki = 4.4 nM) that also blocks ERG potassium channels (IC₅₀ = ~1 nM); used to study long QT syndrome type 2 and as an antineoplastic agent for decreasing proliferation of various cancer cells.

Blocks cortisol synthesis by inhibiting steroid 11β-hydroxylase in adrenal cortex (IC₅₀ = 7.8 μM); also binds with high affinity to CYP450 in hepatic microsomes and induces rat hepatic CYP1A1 and CYP3A gene expression.

Found in human seminal plasma, 19(R)-hydroxy PGA2 is presumed to be a non-enzymatic dehydration metabolite of 19(R)-hydroxy PGE2, which is also found in semen.

A reversible, cell-permeable inhibitor of Src-family tyrosine kinases that have been mutated, by a single base substitution, to become 'analog sensitive' (as), as compared to the wild-type kinase; inhibits v-Src-as1, with an I338G substitution, preferentially over v-Src (IC50 = 1.5 nM versus...

A mono-oxygenation product of DHA in human whole blood, human leukocytes, human glial cells, and mouse brain that is generally reduced to 17(S)-HDHA (Item No. 10009799) in vivo.

An orally bioavailable inhibitor of PARP1 and PARP2 (Kis = 5.2 and 2.9 nM, respectively); enhances apoptosis and autophagy in response to treatments that cause DNA breaks, including radiation and DNA alkylation.

6-keto PGE1 is a metabolite isolated after the incubation of PGI2 with rabbit liver microsomes. However, it is not produced in appreciable amounts following IV infusion of PGI2 in humans. 6-keto PGE1 is equipotent with PGI2 as a vasodilator; in most other aspects its activity resembles PGE1.

A histamine H1 receptor antagonist (Ki = 0.4 nM; IC₅₀ = 45 nM) that does not cross the blood brain barrier; 10 μM inhibits T cell proliferation and the production of Th2-type pro-inflammatory cytokines by macrophages.

TBS stock solution (10X, pH 7.4) contains filtered concentrated TBS. It is ready to use as supplied.

A hydrophobic diterpene ester that rapidly induces cell death in proliferating keratinocytes through plasma membrane and mitochondrial disruption; causes inflammation due, at least in part, to activation of PKC, leading to antibody-dependent cellular cytotoxicity.

A SMO agonist that can promote the differentiation of multipotent mesenchymal progenitor cells into osteoblasts (EC₅₀ = 1.2 µM); used to characterize a novel SMO active site since it does not recognize the classic cyclopamine binding site utilized by other SMO agonists.

Promotes the cytochrome c-dependent oligomerization of Apaf-1 into the mature apoptosome, thus increasing procaspase-9 processing and subsequent caspase-3 activation; induces apoptosis in leukemia cells (IC50 = 4-9 μM)

A potent blocker of small conductance Ca2+-activated K+ (SK, KCa2) channels that is more effective at SK2 than SK1 and SK3 (IC₅₀ values are 0.06-0.4, 1-12, and 1-13 nM, respectively); ineffective against SK4 at 1 µM.

A potent, specific, ATP-competitive, and cell permeable inhibitor of ROCK (Ki = 1.6 nM); more potent inhibitor of ROCK than either Y-27632 (Ki = 140 nM) or HA-1077 (Ki = 330 nM); poorly inhibits PKA, PKC, and MLCK.

A certified reference material categorized as a phytocannabinoid metabolite; a metabolite of cannabidiol; intended for research and forensic applications