Cayman Chemical

A cell-permeable, competitive, and irreversible inhibitor of all caspases, inhibiting cleavage of PARP and preventing apoptosis when used at 10-50 µM; blocks caspase-mediated apoptosis in vivo; effectively prevents caspase action in inflammasomes.

A synthetic intermediate useful for pharmaceutical synthesis.

LY83583 is an inhibitor of soluble guanylate cyclase and of cGMP production. It inhibits soluble guanylate cyclase in human platelets with an IC₅₀ value of 2 µM. LY83583 also inhibits leukotriene synthesis in guinea pig lung and rat peritoneal cells with an IC₅₀ value of...

A competitive inhibitor of isoprenylated protein methyltransferase (also known as S-adenosylmethionine-dependent methyltransferase).

A-77-01 is a potent inhibitor of the TGF-β1 receptor ALK5 (IC₅₀ = 25 nM). It has no effects on BMP-regulated transcriptional activity or MAPK pathways. A-77-01 efficiently prevents the growth inhibitory effects of TGF-β on lung epithelial Mv1Lu cells. It completely blocks...

An internal standard for the quantification of eicosapentaenoic acid ethyl ester.

A synthetic oxysterol compound that may function as an antagonist of hedgehog activity.

A selective estrogen receptor modulator that exhibits estrogenic activity in bone cells without stimulating breast or endometrial tissue.

A third-generation heterocyclic nitrogen-containing bisphosphonate that inhibits the prenylation of GTPases critical to the signaling events related to osteoclast-mediated bone resorption; has a high affinity for hydroxyapatite (Ki = 3.47 μM) and binds directly to mineralized bone where it...

Molecular Formula: C₁₇H₁₃NO

An antimitotic vinca alkaloid which irreversibly blocks mitosis by binding to tubulin (Ki = 85 nM) and inhibiting tubulin polymerization; exported from cells via the ABC transporter P-glycoprotein but not by Mrp1.

A stable analog of PGH2 and a TP receptor agonist; stimulates shape change in human platelets without a measureable increase in Ca2+ with an EC₅₀ value of 1.8 nM.

5(Z),8(Z),14(Z)-Eicosatrienoic acid is a PUFA that can be a substrate for 5-LO. 5-LO from RBL-1 cells converts this fatty acid to 5-hydroxy-6,8,14-eicosatrienoic acid and 5-hydroperoxy-6,8,14-eicosatrienoic acid. Due to the lack of a double bond at C-11, this particular fatty acid cannot be used in...

A derivative of (±)5(6)-EET which is stable enough to ship and handle routinely.

The reduced form of nicotinamide adenine dinucleotide that can donate electrons as part of a reducing reaction.

A potent inhibitor of GSK3α/β (IC₅₀ = 10 nM), with selectivity over Cdk5/p25, Cdk2/A, and Cdk1/B (IC₅₀s = 2.4, 4.3, and 63 µM, respectively); suppresses the cytopathic effects of herpes viruses and reduces viral yields in human oral epithelial cells.

A natural intermediate involved in the pentose phosphate pathway leading to purine, pyrimidine, and histidine metabolism.

An α2-adrenergic receptor antagonist (Kd = 2.6 µM) and an L-type calcium channel blocker (IC₅₀ = 17 µM) well-known for its coronary vasodilator effects; inhibits K-Ras plasma membrane localization (IC₅₀ = 9.64 µM), blocking the proliferation of...

A potent and selective competitive inhibitor of nNOS (Ki = 57 nM; bovine); exhibits 3,000-fold and 150-fold selectivity for the neuronal isoform versus the inducible (murine; Ki = 180 µM) and endothelial (bovine; Ki = 8.5 µM) isoforms of NOS, respectively.

A cell-permeable inhibitor of Cdk1/cyclin B and Cdk2/cyclin A (IC₅₀s = 0.6 and 0.5 nM, respectively); blocks the growth of several cancer cell lines (IC₅₀ values range from 20 to 92 nM).

A prodrug that is metabolized in vivo to RNH-6270, a nonpeptide angiotensin II antagonist that potently inhibits angiotensin binding to the AT1 receptor (IC50 = 7.7 nM) without affecting binding to the AT2 receptor; reduces blood pressure.

A synthetic intermediate useful for pharmaceutical synthesis.

Source: Active recombinant N-terminal Strep II-tagged protein expressed in E. coli Mr: 40.8 kDa JMJD2E catalyzes the demethylation of histone H3 at lysince residue 9. JMJD2E is an α-ketoglutarate-dependent Fe (II) oxygenase. Purification of Fe-dependent JmjC family members by IMAC can result...

Antigen: synthetic peptide from human S1P4 wihin the region of amino acids 1-50 Host: rabbit Cross Reactivity: (+) human and mouse S1P4 Application(s): ICC, IF, and WB Binding of S1P to S1P4 activates Erk, leading to the activation of the transcription factor Elk1 and thus the MAPK signal...