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An antagonist of GPR55, blocking LPI-induced activation (EC50 = 1.1 µM); has minimal effect at the GPR35 and CB2, although it acts as a weak antagonist of CB1 (IC50 = 17.7 µM); inhibits LPI-induced phosphorylation of ERK1/2 and blocks receptor-dependent...
An internal standard for the quantification of Lipoxin A4 by GC- and LC-MS.
Cayman's MC3R Reporter Assay consists of a 96-well plate coated with a transfection complex containing DNA constructs for MC3R and a cAMP response element regulated Secreted Alkaline Phosphatase (SEAP) reporter (MC3R Reverse Transfection Strip Plate). Cells grown on the transfection complex will...
A receptor antagonist acting at the muscarinic receptors (Ki = 5.5, 47, 0.84, 8.6, and 2.3 nM for M1 through M5, respectively); effective in treating problems related to the lower urinary tract.
Inhibits the Pdr5p in yeast, augmenting, at concentrations as low as 0.8 μM, the ability of cerulenin or cycloheximide to impair cell proliferation; inhibits ACAT (IC50 = 113 μM), blocking cholesteryl ester formation.
Contains a collection of vasoactive eicosanoids, including the characteristic metabolites of both PGI2 and TXA2 and several additional metabolites produced by platelets and the CYP450 pathway of arachidonic acid metabolism; designed for direct use in LC-MS applications.
An inhibitor of adenylyl cyclase (IC50 = 13 μM) that inhibits PGE1-stimulated increases in cAMP levels in intact platelets; used to evaluate adenylyl cyclase activity during iloprost-induced vasorelaxation, inhibiting cAMP elevation (100-300 μM) without effecting relaxation.
Peptide Sequence: human amino acids 59-75 (CRSDPDVERSLRAHRND) To be used in conjunction with Cayman’s microsomal PGE synthase-1 polyclonal antibody (Catalog No. 160140) to block protein-antibody complex formation during analysis for microsomal PGE synthase.
A cell-permeable, potent inhibitor of both SHP-1 and SHP-2 (IC50 = 355 and 318 nM, respectively); much less effective against other protein tyrosine phosphatases and DUSP26.
A FAHFA in which palmitic acid is esterified at the 5th carbon of hydroxy stearic acid; synthesized in vivo and regulated by fasting and high-fat feeding in mice; lowers ambient glycemia, improves glucose tolerance, and stimulates GLP-1 and insulin secretion in mice.
Catechin is a polyphenolic flavonoid which has been isolated from a variety of natural sources including tea leaves, grape seeds, and the wood and bark of trees such as acacia and mahogany. Catechin is a more potent antioxidant than ascorbate or α-tocopherol in certain in vitro lipid...
A potent, selective, and bioavailable inhibitor of the TRPA1 channel, with IC50 values of 67 and 289 nM for the human and rat isoforms, respectively; attenuates cold allodynia following nerve injury and suppresses neuronal activity in response to mechanical stimulation.
A FAHFA in which stearic acid is esterified to 5-hydroxy stearic acid; may have roles in metabolic syndrome and inflammation.
Antigen: histone 3 peptide with citrullinations at R2, R8, and R17 Isotype: IgG1 Host: rabbit Species Reactivity: (+) human Application(s): ELISA and WB
An ATP-competitive CDK inhibitor; inhibits CDC2/cyclin B (IC50 = 7 µM), Cdk2/cyclin A (IC50 = 7 µM), Cdk2/cyclin E (IC50 = 7 µM, Cdk/p35 kinase (IC50 = 3 µM), and ERK1/p44 MAPK (IC50 = 25 µM).
A potent lipid signaling molecule that exhibits a wide range of biological activities; it enhances cell growth and inhibits the normal apoptotic response to a variety of stimuli.
An analog of MAFP, which has been widely studied as an inhibitor of phospholipases, FAAH, and as a CB receptor ligand; pharmacology of the γ-linolenyl analog of MAFP has not been completely investigated.
An inhibitor of EGF receptor kinase with an IC50 value of 0.8 µM in the human epidermoid carcinoma cell line A431.
An analog of N-butyryl-L-HSL, the small diffusible signaling molecule involved in quorum sensing, controlling gene expression, and cellular metabolism; induces violacein expression in C. violaceum mutants usually not able to produce AHLs.
A potent and selective dual inhibitor of EGFR and HER2 (IC50s = 19 and 3 nM, respectively); used in combination therapy to prevent or suppress cancers where these kinases are over-expressed, including breast cancer.
A synthetic analog of dolastatin 10 that inhibits tubulin polymerization and exhibits potent cytotoxicity; commonly conjugated with monoclonal antibodies directed at antigens specific to cancer cells for tumor-directed cytotoxicity.
A homolog of EPEA, characterized by the addition of an (S)-β-methyl group at the terminal ethanolamine carbon.
An internal standard for the quantification of 9-OxoODE by GC- or LC-MS.
Fluprostenol is a well-studied, potent analog of PGF2α and acts primarily through the FP receptor. Oxidation at C-9 of fluprostenol yields 9-keto fluprostenol. Prostaglandin esters are known to be hydrolyzed in the eye to the corresponding free acids. However, the use of prostaglandin esters...