Cayman Chemical

A purine base modified by the addition of a methyl group that is used as a biomarker for some types of cancer; closely resembles the 5’ terminal cap structure present on eukaryotic mRNA.

A natural resorcylic lactone derived from fungi that selectively inhibits purified TAK1 (IC₅₀ = 8.1 nM when co-expressed with the TAK1-binding protein, TAB1); irreversibly blocks IL-1-induced activation of TAK1, NF-κB, and JNK/p38 (IC₅₀s = 65-83 nM) and sensitizes cells...

An antibiotic that inhibits growth in various tumor cell lines (IC₅₀s = 1-5 µM) by activating caspases 8 and 3.

Molecular Formula: C₃₉H₅₁N₆O₉ • 3I

An antagonist of the 5-HT2C receptor (pKi = 9.0), with at least 100-fold more selectivity over other 5-HT, dopamine, or adrenergic receptors; brain penetrant with significant anxiolytic activity; used extensively in animal research.

This nuclear receptor assay system utilizes proprietary non-human mammalian cells engineered to provide constitutive, high-level expression of human constitutive androstane receptor, isoform 3 (NR1I3), a ligand-dependent transcription factor commonly referred to as CAR3. These reporter cells utilize...

A furanocoumarin with antibacterial activities; prevents tacrine-induced cytotoxicity in HepG2 cells (EC50 = 47 μg/ml) and vascular relaxation in phenylephrine-precontracted rat aorta; weakly inhibits topoisomerase II (IC50 = 404 μM).

A derivative of fluphenazine that contains an alkylating chlorethylamine chain, which produces irreversible protein binding; a relatively selective, irreversible antagonist of D2 receptors both in vitro (IC₅₀ = 100 nM) and in vivo; irreversibly inhibits calmodulin at higher doses...

An inhibitor of PDE4 (IC₅₀ = 54-239 nM) that, at higher doses, also inhibits PDE3 and PDE5 (IC₅₀ = 1,600-3,510 nM); suppresses the elaboration of mediators involved in asthma and inflammation.

A nonenzyme-dependent degradation product of rapamycin resulting from ester hydration followed by dehydration; secreted from cells by P-glycoprotein; poorly activates mTOR but, like rapamycin, inhibits the proteasome.

A synthetic intermediate for pharmaceutical synthesis.

Antigen: human doppel amino acids 112-120 (ATQAANQGE) Host: rabbit Cross Reactivity: (+) human, mouse, and rat doppel; other species not tested Applications: WB and IHC (formalin-fixed paraffin-embedded sections); other applications not tested

A quinone which inhibits topoisomerase I at 25 μM and transglutaminase (IC₅₀ = 5 μM); reduced to β-lapachone hydroquinone by NQO1, generating ROS during its reversion to β-lapachone; sensitizes cancer cells to radiation, suppresses NF-κB activation, and drives...

An indolizidine alkaloid naturally found in certain plants that inhibits N-linked glycoside hydrolases, preventing the processing of asparagine-linked glycoproteins; reversibly inhibits lysosomal α-mannosidase and Golgi α-mannosidase II (IC₅₀ = 0.2 μM); shown to have...

Antigen: human GPR40 amino acids 210-222 Host: rabbit Cross Reactivity: (+) human GPR40 Application(s): IHC and WB GPR40 is a GPCR found predominantly in the b-cells of pancreatic islets that has been implicated in the regulation of insulin secretion. Overexpression of GPR40 in mouse b cells leads...

This assay utilizes proprietary non-human mammalian cells that express mouse constitutive androstane receptor (nr1I3), a ligand-dependent transcription factor referred to as mCAR. These reporter cells utilize a modified version of mCAR in which the N-terminal DNA binding domain (DBD) has been...

A broad-spectrum triazole active against various yeasts and molds, including Aspergillus, Candida, Fusarium, and Zygomycetes; inhibits the growth of fungi by inhibiting the lanosterol 14α-demethylase (IC₅₀s range from 7-200 nM), a key enzyme in the synthesis of ergosterol.

9-OxoOTrE is produced by the oxidation of 9-HpOTrE. 9-OxoOTrE exhibits antimicrobial activity against plant pathogenic microorganisms including bacteria and fungi.

A racemic mixture of D- and L-phosphinothricin, used as the active ingredient in broad spectrum herbicides; also used, with the bar gene, which encodes phosphinothricin acetyltransferase, for selection during genetic engineering in plants.

SMIT is a potent non-selective inhibitor of NOS isoforms in vitro but may lack good in vivo efficacy due to poor cellular penetration. The Ki values are 120, 200, and 160 nM using purified human iNOS, eNOS, and nNOS, respectively.

A prodrug for 5-ASA, which is effective against Crohn’s disease and ulcerative colitis in animal models and clinical trials.

A broad spectrum antibiotic that alters translation by prokaryotic ribosomes, resulting in bacterial cell death; used as a selective agent to isolate transformants that are expressing a kanamycin resistance gene, usually neomycin phosphotransferase (NptII/neo).

INDIGO’s panel of ER assays utilizes non-human mammalian cells engineered to express human estrogen receptors alpha (ER1; NR3A1) and beta (ER2; NR3A2), ligand-dependent transcription factors commonly referred to as ERα and ERβ. INDIGO’s ER reporter cells include the luciferase...

Molecular Formula: C₂₆H₂₄ClFN₄O • C₄H₄O₄