Cayman Chemical

MPB is a versatile thiol-specific biotinylating reagent. It is specific for sulfhydryl groups or reduced disulfide bonds and will not label proteins lacking a free sulfhydryl group at a pH between 6.5 and 7.5. This probe can be used in combination with the appropriate avidin- or...

A 2-hydroxy-6-alkylbenzoic acid in which the alkyl chain contains 15 carbons and is unsaturated at the 8 position; inhibits SUMOylation in vitro (IC₅₀ = 3 µM) and in cells without affecting protein ubiquitination; directly binds the SUMO-activating enzyme E1, blocking the formation...

A 12-carbon cyclopentanone that is structurally related to a variety of plant oxylipins.

A metabolite of tamoxifen that is produced by the action of flavin-containing monooxygenases.

A potent CCKB/gastrin receptor antagonist that exhibits selective binding for CCKB compared to CCKA; exhibits synergistic inhibitory effects on the cell viability of human gastric cancer cells when administered in combination with the selective COX-2 inhibitor NS-398.

Dieosinediglutathione is the product of glutathione disulfide and eosin isothiocyanate which has been purified and lyophilized. This glutathione disulfide derivative has low fluorescence due to self-quenching. The monomer eosinglutathione (EGSH) has high fluorescence. This product can be used for...

A mixture of compounds that can be isolated from plants in the genus Cannabis; designed for use as a reference standard for these major controlled substances during routine analytical checks using HPLC-UV instrumentation; contains tetrahydrocannabinols

The four tocopherols (α, β, .delta., and γ) and four tocotrienols (α, β, .delta., and γ) are forms of vitamin E, which is known for its antioxidant activity. Tocotrienols are found at high concentrations in palm oil and rice bran. Recent studies show tocotrienols...

An organophosphorus ester that antagonizes the CB1 receptor and inhibits FAAH with similar potencies (IC50s = 2 nM).

An O-methylated anthocyanidin that imparts blue-red pigments to flowers, fruits, and red wine; suppresses the activity of focal adhesion kinase and the proliferation of HCT116 colon cancer cells.

A potent inhibitor of p38 MAP kinase (IC₅₀ = 35 nM).

An acyclic nucleoside phosphonate that is active against many different viruses including herpesvirus CMV; selectively inhibits CMV replication and CMV DNA synthesis (IC₅₀ = 0.1 μM).

A succinimide that is converted to N-desmethylmethosuximide, a channel blocker that targets low threshold calcium currents; inhibits CYP2C19-mediated metabolism of biguanides; has anticonvulsant properties in clinical trials.

13(S)-HODE-d4 contains four deuterium atoms at the 9, 10, 12, and 13 positions. It is intended for use as an internal standard for the quantification of 13(S)-HODE by GC- or LC-MS.

A non-ionic, water-soluble X-ray contrast agent for intravascular administration; can cause acute kidney injury and is used in animal models of contrast-induced nephropathy.

Sodium Phosphate Stock Solution (500 mM, pH 8.0) contains filtered sodium phosphate (500 mM, pH 8.0). It is ready to use as supplied.

PGB3 is a non-enzymatic dehydration product resulting from the treatment of PGE3 with strong base. In a structure-activity binding study to determine the affinity of various prostaglandins to human PPARγ, PGB3 exhibited a Ki value greater than 1 mM.{11138} In contrast, PGB1 and PGB2 showed...

A selective IDE inhibitor that selectively targets cysteine819 in IDE with an EC₅₀ value of 188 nM.

A photoactive probe that has been used to investigate nucleic acid structure and function; induces DNA interstrand crosslinks, resulting in apoptosis.

A hybrid molecule patterned after arachidonoyl serotonin; while saturated 11- or 12-fatty acids linked to serotonin potently inhibit capsaicin-induced TRPV1 channel activation (IC₅₀ =0.76 μM) without blocking FAAH-mediated hydrolysis of arachidonoyl ethanolamine (IC₅₀ >...

A synthetic intermediate useful for pharmaceutical synthesis.

17-trans PGE3 is an isomer of PGE3 which could theoretically result from the COX metabolism of dietary trans-fatty acids. There are no published reports on the biological activity of this compound.

PAD4 is a guanidino-modifying enzyme that functions as a transcriptional coregulator catalyzing the conversion of specific arginine residues to citrulline. Substrates for PAD4 include histones H2A, H3, and H4. PAD4 autocitrullinates itself at several sites, inhibiting its enzymatic activity. PAD4...

A potent TRPV1 antagonist that inhibits capsaicin-induced and acid-induced activation of rat TRPV1 with IC50 values of 35 and 6 nM, respectively.