Cayman Chemical

A product of constitutive tryptophan catabolism via tryptophan-2,3-dioxygenase in the liver and human gliomas that is associated with the suppression of antitumor immune responses; activates the AhR target gene CYP1A1 (EC50 = 12.3 μM) and binds to AhR (Kd ~4 μM).

A potent, selective inhibitor of KIAA1361 (IC50s = 20 nM in mouse brain membrane proteomes and 6-12 nM in human PC3 prostate cancer cell proteomes); reduces PC3 tumor xenograft growth in immune-deficient SCID mice at an oral dose of 80 mg/kg.

An irreversible inhibitor of the chymotrypsin-like β5 subunit of the constitutive 20S proteasome (IC₅₀ = 5.2 nM) and the β5i subunit of the immunoproteasome 20Si (LMP7; IC₅₀ = 14 nM) with minimal cross reactivity to other proteases; induces cell cycle arrest and...

LH 846 is a benzothiazole analog that selectively inhibits casein kinase (CK) 1δ (IC₅₀ = 290 nM). It inhibits CK1ε and CK1α at much higher concentrations (IC₅₀s = 1.3 and 2.5 μM, respectively) but does not inhibit CK2. LH 846 has been shown to inhibit...

An isoflavonoid phytoestrogenic compound found in soy-based foods; acts as an agonist of the aryl hydrocarbon receptor (EC₅₀ = 0.13 µM) and has been reported to possess antitumor and antiviral activity.

An orally bioavailable, selective inhibitor of EZH2 (Ki = 2.5 nM); blocks H3K27 trimethylation in both wild-type and mutant lymphoma cells (IC₅₀s range from 2-90 nM); induces apoptosis and differentiation specifically in SMARCB1-deleted malignant rhabdoid tumor cells and promotes their...

A selective, cell-active, small molecule inhibitor of SMYD2 (IC₅₀ = 15 nM); inhibits p53 lysine370 monomethylation in KYSE-150 esophageal squamous cell carcinoma cells stably expressing SMYD2 with an IC₅₀ value of 0.6 µM.

A selective slow off-rate inhibitor of Raf kinases (IC₅₀s = 8.3, 2.4, and 1.4 nM for wild type B-Raf, mutant B-RafV600E, and c-Raf, respectively); shows significant antiproliferative activity against mutated BRAF or mutated NRAS cancer cell lines and xenograft models.

The Rho family of GTPases regulates diverse signal transduction pathways. One member, the cell division control protein 42 homolog (Cdc42), is involved in filopodia function, cell polarity, cell cycling, and other processes. CASIN is an indole-based small molecule that inhibits activation of the...

An analog of U-46619, a stable analog of the endoperoxide PGH2 in the arachidonic acid metabolic pathway.

A non-peptide antagonist of C3aR, competitively blocking C3a binding with an IC₅₀ value of 200 nM; potently inhibits a wide variety of C3a-induced responses in cells, including calcium increase in human neutrophils (IC₅₀ = 28 nM); also effective in vivo, reducing inflammation...

Cayman’s Antioxidant Assay measures the total antioxidant capacity of plasma, serum, urine, saliva, or cell lysates. The assay relies on the ability of antioxidants in the sample to inhibit the oxidation of ABTS (2,2'-azino-di-[3-ethylbenzthiazoline sulphonate]) to ABTS•+ by...

A naturally-derived flavone with anti-inflammatory, anti-oxidative, and anti-tumor effects; induces apoptosis in human cancer cells; down-regulates certain genes responsible for cellular oxidative stress, and acts as a selective PPARα agonist (IC₅₀ = 1.18 µM) and 5-LO...

A potential antineoplastic agent.

An inhibitor of TrkA (IC₅₀ = 1.7 nM), TrkB (IC₅₀ = 0.1 nM), and TrkC (IC₅₀ = 0.1 nM), as well as ROS1 (IC₅₀ = 0.2 nM) and ALK (IC₅₀ = 1.6 nM); blocks proliferation of ALK-dependent cell lines, including those with L1196M or C1156Y resistance...

A cationic rhodacyanine dye that inhibits the Hsp70 family of chaperones; demonstrates antiproliferative activity against cancer cell lines (EC₅₀s = 1.4-2.2 µM in vitro) through its ability to abrogate the interaction of the chaperone with the tumor suppressor p53.

ODQ is a highly selective, irreversible, heme-site inhibitor of soluble guanylyl cyclase. The binding of ODQ is competitive with NO. The inhibition of soluble guanylyl cyclase is time dependent with complete inactivation in 10 minutes at 0.3 µM ODQ.

A natural flavanone glycoside formed from naringenin and neohesperidose; undergoes extensive metabolism in the liver, giving rise to naringenin and other bioactive metabolites that have anti-oxidant, anti-inflammatory, and anti-apoptotic effects.

SEIT is a potent inhibitor of NOS in vitro but lacks good in vivo efficacy due to poor cellular penetration. The Ki values are 19, 39, and 29 nM using purified human iNOS, eNOS, and nNOS, respectively.

A water soluble organosulfur compound derived from garlic that has neuroprotective, antioxidative, and anti-amyloidogenic properties.

Peptide Sequence: CRTH2/DP2 protein amino acids 2-21 To be used in conjunction with Cayman’s CRTH2/DP2 Receptor (N-Term) polyclonal antibody (Item No. 10004886) to block protein-antibody complex formation during immunochemical analysis of CRTH2/DP2

A receptor tyrosine kinase inhibitor that targets VEGF, bFGF, and PDGFβ receptors, preventing the growth and motility of various cancer cell lines and endothelial cells.

Antigen: human caspase-9 amino acids 299-318 Host: rabbit Application(s): WB Caspase-9 is activated by granzyme B, CPP32, or by binding Apaf-1. Activated caspase-9 cleaves and activates caspase-3, playing a central role in cell death induced by a wide variety of apoptosis inducers including...

An ATP-competitive B-Raf inhibitor (IC₅₀ = 10 nM; Kd = 2.4 nM) that inhibits cell proliferation both in B-Raf mutated and wild-type melanoma cell lines.