Cayman Chemical

The angiotensin II (AII) inhibition cocktail has been developed by Bertin Pharma in order to fix physiological concentration of AII in biological samples, namely blood. Indeed, it has been observed that sample preparation is highly recommended when dosing AII for preventing the formation or...

A bactericidal thioamide effective against M. tuberculosis (MIC = ~0.5 µg/ml), M. leprae (MIC = 0.8-1.6 mg/L), and M. avium; inhibits mycolic acid biosynthesis (Ki = 2 nM).

Host: mouse, clone 18F6 Isotype: IgG1κ Application(s): ELISA and WB

Glucose-6-phosphate dehydrogenase (G6PDH) is a cytosolic enzyme that catalyzes the first step in the pentose phosphate pathway. This pathway includes converting glucose to ribose-5-phosphate, a precursor to RNA, DNA, ATP, CoA, NAD, and FAD. The pathway also generates NADPH. G6PDH deficiency, the...

A quinazolinone derivative that selectively inhibits dynamin GTPase activity in yeast and mammalian cells (IC₅₀ = 1-10 μM); prevents apoptosis by inhibiting mitochondrial outer membrane permeabilization.

A chalconoid with anti-inflammatory and anti-tumor activity; suppresses NO and PGE2 synthesis, COX-2 expression, and NF-κB signaling; induces apoptosis in cancer cells.

A prominent amino-acyl endocannabinoid isolated from rat brain during lipidomics profiling; may activate TRPV1 and TRPV4.

A selective COX-2 inhibitor that exhibits IC50 values of 26.1 and 0.87 µM for COX-1 and COX-2, respectively, in a human whole blood assay.

An an antimicrobial agent that is often used in antiseptics and dental products such as toothpaste and mouthwash; inhibits MMP-2, -8, and -9.

Primes embryonic stem cells for differentiation (EC₅₀ = 0.3 μM) in lineage specification stimulus cues by inhibiting the nuclear localization of NME2 and down-regulating c-Myc expression.

BW 245C is a selective agonist for the DP1 receptor. The Ki of BW 245C for the inhibition of [3H]-PGD2 binding to isolated human platelet membranes is 0.9 nM. It has a reported IC50 of 2.5 nM for the inhibition of ADP-induced human platelet aggregation and an IC50 of 250 nM for the inhibition of rat...

Antigen: mouse COX-2 amino acids 584-598 Host: rabbit Cross-Reactivity: (+) human, macaque monkey, mouse, ovine, and rat COX-2; (−) COX-1 (all species); expected to react with bovine and canine COX-2 Application(s): IHC (formalin-fixed paraffin-embedded tissue) and WB

A steroid hormone produced in the cortex of the adrenal glands that binds to both glucocorticoid and mineralocorticoid receptors; also is the precursor to aldosterone synthesis.

A glycine conjugate of lithocholic acid, a bile acid.

Stearidonic acid is an 18-carbon, ω-3 fatty acid which is a dietary precursor to EPA and DHA. Stearidonic acid is present in small amounts in seed oils, especially black currant seed oil.

Source: Human recombinant PP2A catalytic subunit expressed in insect cells with an N-terminal octahistidine-tag followed by a streptactin-tag. The C-terminal leucine 309 was deleted. MW: 38.6 kDa PP2A is a divalent cation-independent protein serine/threonine phosphatase involved in regulating...

A selective and potent ROCK inhibitor (IC₅₀ = 11.8 nM for ROCK-II); poorly inhibits CaMKII, protein kinase G, and Aurora A (IC₅₀ = 2.57, 2.35, and 3.26 μM, respectively) as well as PKA or PKC (IC₅₀ ≥ 10 μM for each).

A natural coumarin that increases cAMP and cGMP levels through its ability to inhibit phosphodiesterases, which leads to a modulation of calcium channel signaling; exhibits vasorelaxant, immunomodulatory, antioxidative, and anti-inflammatory properties.

A metabolite of vitamin A that acts as a ligand for both the RAR and the RXR.

A site-specific, photoactivatable probe used to detect RNA structures and nucleic acid-nucleic acid contacts.

A certified reference material categorized as a phytocannabinoid; has been found in Cannabis; intended for research and forensic applications

A lipid peroxidation product derived from oxidized ω-6 PUFAs such as linoleic acid and arachidonic acid which is widely used as a marker of lipid peroxidation.

A selective GIRK1/2 activator (EC₅₀s = 0.16 and 1.8 μM for GIRK1/2 and GIRK1/4, respectively; 60 mg/kg can delay seizure onset and prevent convulsions in two different mouse models of epilepsy.

A reagent used to detect singlet oxygen generation; can be photobleached by singlet oxygen to its corresponding endoperoxide.