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PPARγ is a ligand-activated transcription factor involved in the regulation of lipid homeostasis and may function as a master regulator of adipogenesis. Ligands for PPARγ include antidiabetic drugs of the thiazolidinedione structural class, 15-deoxy-.DELTA.12,14-PGJ2, and NSAIDS. BADGE...
An atypical neuroleptic that blocks dopamine and serotonin (5-HT) receptors (Kis = 60, 30, and 30 nM for D2, D4, and 5-HT2A, respectively); an agonist for hM3Dq, a DREADD, with >10,000-fold selectivity for hM3Dq over hM3.
A certified reference material categorized as a phytocannabinoid; has analgesic activity in mice; intended for research and forensic applications
A FAHFA in which stearic acid is esterified to 10-hydroxy stearic acid.
INDIGO’s panel of TR reporter assays utilizes non-human mammalian cells engineered to express human thyroid hormone receptors alpha (NR1A1) and beta (NR1A2), ligand-dependent transcription factors commonly referred to as TRα and TRβ. INDIGO’s TR reporter cells include the...
An inhibitor of HGFR (c-Met).
9(R)-HETE is an enantiomer which makes up 50% of (±)9-HETE (Item No. 34400). At a concentration of 300 nM, 9(R)-HETE activates RXRγ-dependent transcription 1.5 fold relative to a control.
The Fatty Acid ethyl ester Standard pack contains a series of nine fatty acid ethyl esters. Each pack contains 100 mg of the ethyl esters of the following fatty acids: stearic, myristic, linoleic, linolenic, arachidonic, oleic, palmitic, lauric, and palmitoleic.
13-epi-12-oxo PDA is an LO metabolite of α-linolenic acid in the leaves of green plants such as corn. ω-3 and ω-6 PUFAs in plants are substrates for plant LOs. 12-oxo PDA is one of the best studied end metabolites of this enzymatic pathway. While the initial enzymatic product and...
An alkyl bis(biguanide) antiseptic which kills plaque forming microorganisms; binds to LPS and LTA and inhibits fungal phospholipase B (IC50 ~ 250 nM); inhibits the mitochondrial phosphatase PTPMT1 (IC50 = 1.08 μM, in vitro) and induces apoptosis in cancer cell lines...
A selective inhibitor of the MAP kinases p38α (IC50 = 3.2 nM) and p38β (IC50 = 122 nM); has no inhibitory effect against a panel of other kinases when tested in vitro at 50 μM; orally active, significantly reducing p38 MAP kinase expression in T cells of NOD mice...
A fluorescent probe for staining cells with intact membranes (excitation/emission at 494/521 nm).
Antigen: human GPR120 amino acids 364-375 Host: rabbit Cross Reactivity: (+) human GPR120 Application(s): ELISA, ICC, and WB
Peptide Sequence: amino acids 221-235 (VYGGKEARTEEMKWR) To be used in conjunction with Cayman’s mPGE synthase-2 polyclonal antibody (Catalog No. 160145) to block protein-antibody complex formation during analysis for microsomal PGE synthase-2.
8,11,14-Eicosatriynoic acid is an inhibitor of prostaglandin and leukotriene biosynthesis as well as arachidonic acid induced platelet aggregation. It inhibits cyclooxygenase (IC50 = 14 µM), human 12-lipoxygenase (IC50 = 0.46 µM), 5-lipoxygenase (IC50 = 25 µM) and the actions of...
A natural intermediate in the pteridine pathway that can be produced naturally from 7-oxobiopterin or in vitro by the oxidation of pterin by xanthine oxidase.
Immunogen: Synthetic peptide from the C-terminal region of human protein COX-2 Host: Mouse, clone CX229 Isotype: IgG1 Species Reactivity: (+) Human, ovine, and monkey COX-2; (−) Mouse, rat, and rabbit COX-2 and COX-1 (all species) Cross Reactivity: (-) COX-1 (all species) Application(s): WB...
A selective non-peptide agonist of the δ-opioid receptor (Ki = 0.18 nM, IC50 = 2.73 nM) that is over 2,000-fold less effective at the μ-opioid receptor; effectively activates µ/δ receptor heteromers (EC50 = 52.8 nM) but not κ/δ or μ/κ...
One of several isoprostanes produced from peroxidation of arachidonic acid esterified in phospholipids.
An impurity of the tetracycline antibiotic chlortetracycline.
Oxytocin is a hypothalamic peptide hormone that is stored in the posterior pituitary gland. It is released into the bloodstream during parturition and lactation and is also involved in other social and sexual behaviors, neuropsyciatric disorders, and the maintenance of water and sodium homeostasis....
MI-136 is an inhibitor of the menin-MLL interaction (IC50 = 31 nM; Kd = 23.6 nM). By blocking MLL recruitment predominantly at the level of the menin-MLL interaction, it can inhibit androgen receptor (AR)-mediated transcription. At 40 mg/kg, MI-136 has been shown to block AR signaling,...
A potent and selective inhibitor of HDAC6 (IC50 = 0.002 nM, as compared with 271, 252, 0.42, 6851, and 90.7 nM for HDAC1, 2, 3, 8, and 10, respectively); prevents the growth of several pancreatic cancer cell lines (IC50 = 0.1-1 μM).
A calcimimetic compound that can allosterically activate or positively modulate the human CaSR; dose-dependently decreases circulating levels of PTH in both normal individuals and patients with primary hyperparathyroidism in clinical trials.