Cayman Chemical

An amino acid derivative and an intermediate, by-product, or modulator of several metabolic pathways, including the activated methyl cycle and cysteine biosynthesis; also a product of SAM-dependent methylation of biological molecules, including DNA, RNA, and histones, and other proteins.

A brain-penetrant inhibitor of CSF1R, as well as c-Kit and FLT3 (IC₅₀s = 20, 10, and 160 nM in vitro, respectively); blocks macrophage recruitment in mammary tumor-bearing mice and blocks glioblastoma invasion in both cell culture and a mouse model of glioblastoma multiforme.

A mycobacterial ATP synthase inhibitor that demonstrates potent activity against both drug-sensitive and drug-resistant M. tuberculosis with MIC₅₀ values of ~0.03 µg/ml.

A chiral enantiomer of 13,14-epoxy fluprostenol isopropyl ester whose pharmacology has not been studied extensively to date.

A cell-permeable ACL inhibitor (IC₅₀ = 0.13 µM) that has been reported to reduce weight gain and lower plasma cholesterol, triglycerides, and glucose in a mouse model of hyperlipidemia.

A small molecule that at 1-25 µM improves ER protein-folding ability, stimulates the expression of multiple chaperone proteins, and induces phosphorylation of eIF2α to reduce protein synthesis; exerts antidiabetic activity in both ob/ob and diet-induced obese mice at 150 mg/kg, improving...

An activator of PLC that stimulates superoxide generation, increase in cytoplasmic calcium, and inositol phosphate formation in human neutrophils when used at a concentration of 15-50 µM; promotes the hydrolysis of phosphatidylinositol bisphosphate by all PLC isoforms.

An inhibitor of the release of IL-17 by CD4 T cells stimulated with IL-15, either alone or in combination with CXCL12 and anti-CD3 monoclonal antibody (IC₅₀s = 57.4 and 25.7 nM, respectively); reduces the expression of inflammatory cytokines and inhibits joint destruction in...

Balicatib is a potent inhibitor of cathepsin K (IC₅₀s = 1.4, 56, and 480 nM for human, rat, and mouse forms, respectively). It is at least 100-fold selective for cathepsin K over cathepsins B, L, and S. Balicatib has a basic lipophilic nature, resulting in lysosomal trapping and increased...

GPx catalyzes the reduction of hydroperoxides, including H2O2, using reduced glutathione and thereby functions to protect the cell from oxidative damage. Cayman’s Glutathione Peroxidase Assay measures GPx activity indirectly by a coupled reaction with GR. Oxidized GSSG, produced upon reduction...

Molecular Formula: C₁₂H₈D₄N₂ • 2Br Formula Weight: 348.1

Tris-HCl Stock Solution (1 M, pH 7.0) contains filtered Tris-HCl (1 M, pH7.0). It is ready to use as supplied.

Both DNA and RNA are damaged by oxidation during aging and in a variety of disease states including cancer. The repair processes that are initiated to correct this damage release multiple oxidized guanine species into the urine. Cayman Chemical has developed this immunoassay for the measurement of...

An agonist of muscarinic receptors (EC₅₀ = 1.8-17 µM for human M2).

A 9,11-diketone formed by the oxidation of PGE2 or PGD2.

A synthetic analog of natural PtdIns featuring C16:0 fatty acids at the sn-1 and sn-2 positions; contains the same inositol and DAG stereochemistry as the natural compound.

Eicosatrienoic acid accumulates in the tissues of animals fed diets deficient in both ω-3 and ω-6 fatty acids. It can be converted to 3-series cysteinyl-leukotrienes but cannot serve as a COX substrate. The kidneys from essential fatty acid deficient rats are less immunogenic when...

A fluorogenic substrate for chitinases and chitotriosidases.

A 2-AG analog with increased stability; approximately a log less potent as a CB1 receptor agonist than 2-AG.

An indole-based SERM that binds to both ERα (IC₅₀ = 26 nM) and ERβ (IC₅₀ = 99 nM); antagonizes 17β-estradiol-dependent and hormone-independent growth of breast cancer cell proliferation (80% reduction with 10 nM) in a manner related to cell cycle arrest and...

A small molecule inhibitor of human cytomegalovirus viral replication (EC₅₀ = ~5 nM with a selectivity index >15,000) that targets viral DNA cleavage and packaging.

A pan-Akt inhibitor (Akt1, 2, and 3 IC₅₀s = 3, 7, and 7 nM, respectively) that also inhibits P70S6K and PKA (IC₅₀s = 6 and 7 nM, respectively) and shows >75% inhibition at 1 μM against ROCK-II, MKK1, MSK1, MSK2, PKCγ, PKGα, PKGβ, PRKX, RSK2, and RSK3;...

The ET peptide family consists of three isoforms, ET-1 (corresponding to the initially isolated and most predominant isoform), ET-2, and ET-3. ET-1 is a 21 amino acid peptide and is one of the most potent vasoconstrictors currently known. ET-2 displays similar pharmacology to ET-1, whereas ET-3 is a...

An inhibitor of Aβ oligomerization and fibrillization (IC₅₀ = 50 nM for formation of fibrils from Aβ1-42); reduces the cytotoxic effect of Aβ oligomers in a cultured neuronal cell line.