Cayman Chemical

Antigen: rat FAAH amino acids sequence 561-579 Host: rabbit Cross Reactivity: (+) human, ferret, mouse, and rat FAAH; other species not tested Application(s): WB

An HDAC inhibitor with an IC50 value of 30 µM when tested in HeLa cell nuclear extracts using 200 µM acetylated fluorometric substrate.

1,8-ANS is a fluorescent dye that binds with high affinity to hydrophobic surfaces of proteins. The emission maximum of 1,8-ANS undergoes a blue shift and fluorescence intensity increases significantly upon binding to low polarity regions of a protein surface. These properties make 1,8-ANS well...

Antigen: mouse TLR12 amino acids 911-926 Host: rabbit Cross Reactivity: (+) mouse and rat TLR12 Application(s): FC (intracellular) and WB TLR12 displays a distinct pattern of expression in macrophages, liver, kidney, and bladder epithelial cells. TLR12 does not respond to known TLR ligands.

An intermediate in the generation of adenine and methionine that is produced by the decarboxylation of SAM; a potent agonist of adenosine receptors (Kis = 0.15, 1.13, 13.9, and 0.68 μM for A1, A2A, A2B, and A3, respectively); inhibits several enzymes at higher concentrations.

Immunogen: synthetic peptide from the N-terminal region of human IP receptor Host: rabbit Species Reactivity: (+) human IP receptor Application(s): WB The IP receptor is a GPCR that mediates the action of PGI2. It participates in signal transduction of the pain response, cardioprotection, and...

A PPARγ agonist that is 4-fold more potent than rosiglitazone at the PPARγ receptor demonstrating an EC50 value of 0.05 µM; shows high selectivity for PPARγ over PPARα (EC50 = 3.99 µM) or PPARδ (EC50 > 10 µM).

Several different arachidonoyl amino acids, including NALA, have been isolated and characterized from bovine brain. The glycine congener (NAGly) was found to suppress formalin-induced pain in rats. NALA may act at the CB receptors and/or TRPV1, but has not yet been fully characterized.

A modified nucleoside derived from 5-methylcytosine and is a minor constituent of RNA as well as DNA for certain organisms; used in epigenetics research, especially in studies involving DNA methylation processes.

A certified reference material categorized as a phytocannabinoid; a common component of hashish but is not psychoactive until heating, which converts it to ?9-THC; provided as a DEA exempt preparation; intended for research and forensic applications

Ciprostene is the 9β-methyl analog of carbaprostacyclin and a stable analog of PGI2. Ciprostene exhibits biological activity similar to PGI2, but is 30-fold less potent. In patas monkeys, ciprostene induces hypotension and causes tachycardia when administered at a dose of 0.16 µg/kg/min....

A selective inhibitor of AEA uptake that is resistant to FAAH hydrolysis; is the structurally "reversed" isomer of AM404; blocks the uptake of tritiated AEA with an EC50 value of about 1.5 µM in mouse cortical neurons.

A key dihydroxy fatty acid derived from AA through the 5-LO pathway; promotes a number of leukocyte functions including chemotaxis and chemokinesis at subnanomolar concentrations.

Specifically inhibits Gcn5-dependent acetylation of histone H3K14 at a concentration of 0.8 mM both in vitro and in vivo.

An inhibitor of TOPK (IC₅₀ = ~2 µM), Chk1 (IC₅₀ = 9.6 µM), and MEK1 (40% inhibition at 5 µM); decreases the growth of colon cancer and glioma initiating cells in vitro and suppresses tumor growth in vivo.

A nuclear receptor cell-based reporter assay.

A progestin that is a racemic mixture of which levonorgestrel is the biologically active component.

An inhibitor of the Rac subfamily of Rho GTPases, that binds to Rac1, Rac1b, Rac2, and Rac3 with Kd values of 40, 50, 50, and 250 nM, respectively; has inhibitory effects on APP processing, breast cancer cell invasion, and growth of dendritic spines.

An aromatic compound that stimulates the proliferation of peripheral blood mononuclear cells and increases the production of TNF-α, IL-2, and IFN-γ; promotes the maturation of dendritic cells and induces the proliferation of neural stem cells both in vitro and in vivo.

N-Oleoyl glycine is a putative substrate for peptidyl glycine α-amidating enzyme in the biosynthesis of oleoyl amide.

A mixture of moenomycins A, A12, C1, C3 and C4, which are antibiotics isolated from several strains of Streptomyces that directly inhibit bacterial peptidoglycan glycosyltransferases; minimal inhibitory concentration of moenomycin A against various Gram-positive bacteria ranges from 1-100 nM.

A naturally-occurring sterol and biosynthetic precursor of several animal, fungal, and protozoan steroids, including cholesterol and ergosterol.

A fluoroquinolone antibiotic that is used topically.

A small molecule pan activator of Ras-related GTPases, activating cdc42, Ras, and Rac1 with EC₅₀ values of 102, 109, and 151 nM, respectively.