An inhibitor of TrkA (IC50 = 1.7 nM), TrkB (IC50 = 0.1 nM), and TrkC (IC50 = 0.1 nM), as well as ROS1 (IC50 = 0.2 nM) and ALK (IC50 = 1.6 nM); blocks proliferation of ALK-dependent cell lines, including those with L1196M or C1156Y resistance mutations; induces tumor regression in mice bearing various Trk, ROS1, or ALK-driven xenografts.