Cayman Chemical

An inhibitor of several ASK isoforms when given at a concentration of 10 µM, leaving residual kinase activity at less than 10% for ASKα, γ, ε, ζ, η, ι, and 20% for ASKθ, without inhibiting isoforms β and δ; activates signaling induced by...

A homolog of EPEA, characterized by the addition of an (R)-β-methyl group at the terminal ethanolamine carbon.

19(R)-Hydroxylated prostaglandins occur in µg/ml concentrations in the semen of certain mammalian species, especially primates. In the case of humans, the compounds are primarily of the PGE series, and the hydroxyl stereochemistry is 15(S),19(R). 19(R)-Hydroxylated prostaglandins are also...

β-Gal-NONOate is a nitric oxide (NO) donor which releases NO following activation by β-galactosidase. β-Gal-NONOate is stabile in aqueous solution at neutral and acidic pH for several hours, exhibits good water solubility, and is able to cross the cell membrane. Following enzymatic...

A pyrimidine analog derived from deoxycytidine that acts as a substrate for HIV reverse transcriptase (Ki = 51 nM) and inhibits replication of HIV.

A synthetic oxazolidinone antibiotic active against a wide range of Gram-positive bacteria.

A product of the non-enzymatic dehydration of 13,14-dihydro-15-keto PGE2, a process which is accelerated by the presence of albumin.

ALA is an essential fatty acid found in leafy green vegetables. ALA, as part of a low saturated fat diet, helps prevent cardiovascular disease. ALA decreases blood pressure, serum cholesterol levels, and platelet aggregation.

An analgesic and antipyretic compound; inhibits COX-2 activity by more than 80%, albeit at relatively high doses, while it is less effective against COX-1.

4-hydroxy Nonenal-d3 contains three deuterium atoms at the terminal methyl position. It is intended for use as an internal standard for the quantification of 4-hydroxy nonenal (4-HNE) by GC- or LC-mass spectrometry.

An internal standard for the quantification of AEA by GC- or LC-MS.

15(R)-PGE2 is the C-15 epimer of the naturally occurring 15(S)-PGE2. 15(R)-PGE2 is much less potent than the natural stereoisomer in most biological assays. In hamsters, a dose of 0.20 mg of PGE2 inhibits fertility by 100%, whereas a dose of 1.0 mg of 15(R)-PGE2 inhibits fertility by only 17%....

A small diffusible signaling molecule involved in quorum sensing in the model symbiont V. fischeri and the pathogens A. tumefaciens and P. aeruginosa.

A polyunsaturated triacylglycerol with arachidonoyl (20:4) side-chains attached at the C-1, C-2, and C-3 positions that is useful in lipid research.

A six carbon saturated fatty acid with an ω-terminal azide group that allows conjugation via click chemistry; commonly used as a linker that is first acylated to one compound to create a derivative that can then be joined to another compound using click chemistry.

An antagonist of the EP4 receptor (Ki = 1.3 nM) that less potently affects EP3, FP, and TP receptors (Kis = 30, 790, and 2,400 nM, respectively) and is without effect on other prostanoid receptors; implicates EP4 signaling in immune and autoimmune responses, inflammation, and cancer.

An endocannabinoid that contains linoleate in place of the arachidonate moiety of AEA; has been detected in porcine brain and murine peritoneal macrophages and has weak affinity for the CB1 and CB2 receptors (Kis =10 µM and 25 µM, respectively); 4-fold less potent than AEA at causing...

A selective DPP-4 inhibitor (IC₅₀ = 4 nM) that improves glucose tolerance and postprandial plasma insulin levels in Zucker fa/fa rats.

A urinary metabolite of (±)14(15)-EET which is elevated in pregnancy-induced hypertension.

A metabolite of 14,15-LTC4 and 14,15-LTD4 increases vascular permeability of human endothelial cell monolayers with about 10-fold less potency compared LTC4, but approximately 100-fold greater potency than histamine.

A small molecule inhibitor of JAK2 (IC₅₀ = 6 nM) and the related kinases FLT3 (IC₅₀ = 25 nM) and RET (IC₅₀ = 17 nM) with significantly less potent activity against JAK3 (IC₅₀ = 169 nM); inhibits the growth of Ba/F3 cells expressing JAK2V617F or MPLW515L...

A FAHFA consisting of palmitoleic acid esterified to 13-hydroxy stearic acid; significantly elevated in serum of glucose tolerant AG4OX mice; may be a bioactive lipid with roles in metabolic syndrome and inflammation.

A novel analog of PGF2a containing a 17-phenoxy moiety.

Antigen: human Trx1 Host: goat Application(s): ELISA, IHC, and WB