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A coumarin derived from citrus plants with anti-inflammatory, anti-carcinogenic, anti-bacterial, neuroprotective, and hepatoprotective activities; inhibits leukocyte activation and induces phase II enzymes during the initiation phase of carcinogenesis.
An impurity generated in the production of travoprost; a 4:96 diastereomeric mixture of epoxides.
A mycotoxin produced by a variety of molds, including Aspergillus and Penicillium, commonly found in rotting apples; demonstrates an oral LD50 between 29 and 55 mg/kg body weight in rodents and 170 mg/kg body weight in poultry and has been shown to induce nephropathy and gastrointestinal tract...
A sesterterpenoid fungal phytotoxin that binds and irreversibly antagonizes calmodulin, producing anti-leukemic and antimicrobial effects.
Antigen: human ARAP2 within the region of amino acids 1,670-1,720 Host: rabbit Cross Reactivity: (+) human ARAP2 Application(s): IHC and WB ARAP2 is a PIP3-dependent GTPase-activating protein that binds to RhoA-GTP, and modulates actin cytoskeleton remodeling by regulating ARF and RHO family...
Antigen: human PINK1 amino acids 484-504 Host: rabbit Cross Reactivity: (+) human, mouse, and rat PINK1 Application(s): WB and IHC (paraffin-embedded sections) PINK1 was first identified when studying the tumor-suppressive function of the PTEN signaling pathway and is thus believed to be involved in...
A staurosporine analog that inhibits PKC, PKA, CaMKII, and phosphorylase kinase (IC50s = 470, 140, 270, and 1.7 nM, respectively); inhibits PRK1 (IC50 = 3.2 nM in vitro), a PKC-related kinase that phosphorylates histone H3 at threonine 11.
A non-selective P2 purinergic antagonist that blocks recombinant P2X1-5 (IC50s = 1-2.6 μM), native P2Y2-like (IC50 = ~0.9 mM), and recombinant P2Y4 (IC50 = ~15 mM) receptors; produces neuroprotective effects in an ischemia model with permanent middle cerebral...
An abundant naturally occurring ceramide.
An orally bioavailable pan-Raf kinase inhibitor that inhibits MAP kinase pathway signaling in BRAF-mutant melanoma models.
A cyclic oligosaccharide containing seven D-(+)-glucopyranose units that is widely used to improve the aqueous solubility of various compounds, especially those containing a phenyl group.
Host: mouse, clone C-11 Cross Reactivity: (+) human cytokeratins 4, 5, 6, 8, 10, 13, and 18 Application(s): FC and IF Cytokeratins are intermediate filament polypeptides that provide cellular support to epithelial cells as well as contribute to more dynamic processes. Cytokeratins are differentially...
A chromogenic substrate that, like other tetrazolium compounds, can be reduced to produce a colored formazan derivative; used in the “NBT test” to evaluate the activity of NADPH oxidase in phagocytes; paired with PCIB for the colorimetric detection of alkaline phosphatase activity.
PtdIns-(3,5)-P2 (1,2-dipalmitoyl) (sodium salt) is a synthetic analog of natural PtdIns featuring saturated C16:0 fatty acids at the sn-1 and sn-2 positions. The compound features the same inositol and DAG stereochemistry as that of the natural compound. PtdIns-(3,5)-P2 is rapidly synthesized from...
PSN632408 is an optimized agonist of GPR119 receptors that shows similar potency to OEA at both recombinant mouse and human GPR119 receptors, exhibiting EC50 values of 5.6 and 7.9 µM, respectively (EC50 values for OEA are 3.2 and 2.9 µM, respectively). Systemic administration of...
A thyroid hormone generated by deiodination of the prohormone thyroxine (T4); a potent agonist of both thyroid hormone receptors TRα and TRβ (Kis = 2.3 nM for both).
15(S)-HpEPE is a monohydroperoxy PUFA produced by the action of 15-LO on EPA. Although the biological activities of 15(S)-HpEPE have not been well characterized, it is expected to behave similarly to 15(S)-HpETE.
A Cl-amidine derivative with greater cellular potency against PAD4 activity (EC50 = 8.8 µM, vs. >200 µM for Cl-amidine) and a significantly longer in vivo half-life (1.75 h, vs. ~15 min for Cl-amidine); effective in vivo, improving endothelial function while downregulating...
A snake venom-derived toxin that irreversibly binds nAChRs (Ki = ~ 2.5 µM in rat) present in skeletal muscle, blocking action of ACh at the postsynaptic membrane and leading to paralysis.
2-methyl-1,3-Cyclohexanedione is a synthetic intermediate useful for pharmaceutical synthesis.
2-Hydroxymyristic acid is an inhibitor of protein myristoylation requiring about 0.5 mM concentration for full inhibition of acylation.
A certified reference material categorized as a phytocannabinoid; has been found in strains of Cannabis and hemp; considered an impurity in commercial extractions of CBD from hemp; intended for research and forensic applications
An activator of MKK4-dependent macropinocytotic cell death in glioblastoma cells, inducing ATP depletion (IC50 = 3.14 µM at 1 day); orally bioavailable, substantially impairing the growth of engrafted glioblastoma cell tumors in mice.
Source: Recombinant N-terminal GST-tagged protein expressed in E. coli Mr: 57.6 kDa