Cayman Chemical

An irreversible antitumor agent that induces non-apoptotic cell death selectively in tumor cells expressing the small T oncoprotein and oncogenic Ras (IC₅₀s = 1.25-5 µg/ml).

An internal standard for the quantification of 4-HNE mercapturic acid by GC- or LC-MS.

A selective EZH2 inhibitor (IC₅₀s = 0.24, 0.51, and 6.1 nM for wild-type EZH2, Y641N mutant EZH2, and wild-type EZH1, respectively); decreases cellular levels of H3K27me3, triggering cell cycle arrest and apoptosis in NHL cell lines (EC₅₀ = 70 nM) and NHL xenografts (200...

Bicyclo PGE2 is a stable, base-catalyzed transformation product of 13,14-dihydro-15-keto PGE2. 13,14-dihydro-15-keto PGE2 itself is a metabolite of PGE2 found in human plasma at a median level of 20-25 pg/ml. Due to the inherent instability of 13,14-dihydro-15-keto PGE2, it is advisable to quantify...

13(S)-HODE is produced by incubation of linoleic acid with plant and mammalian LOs. It has been shown to inhibit the adhesion of tumor cells to the endothelium at concentrations around 1 µM, and down regulates the expression of the IRGpIIb/IIIa receptor.

A fluorescent indicator dye that can be used to measure intracellular and extracellular chloride concentrations (absorption/emission max: 350/460 nm).

A dehydration product of tetranor-PGEM that can be measured as a surrogate for tetranor-PGEM levels in urine.

A macrolide antibiotic that inhibits bacterial protein synthesis by targeting the 50S ribosomal subunit, blocking the progression of nascent polypeptide chains; inhibits CYP3A4.

The active metabolite of the ACE inhibitor, enalapril; inhibits ACE activity with an IC₅₀ value of 5.8 nM in vitro.

A pan-HDAC inhibitor (IC50 = 77 nM in an in vitro HDAC1 activity assay) that prevents proliferation of ovarian (A2780), colon (COLO 205 and HCT116), and prostate cancer (PC-3) cell lines at IC50 values of 0.48, 0.56, 0.48, and 0.34 μM, respectively; binds all HDAC isozymes with similar affinity...

A synthetic heme analog that selectively inhibits HO-1 (Ki = 11 nM) over HO-2 (IC₅₀ = 7.5 µM); weakly inhibits eNOS and soluble guanylyl cyclase (IC₅₀s = 35 and 30 nM, respectively); prevents hyperbilirubinemia in neonates by blocking HO-1 activity that increases...

Induces the expression of TRAIL at 1-5 µM in a p53-independent manner; orally active, stable, and crosses the blood-brain barrier; suppresses the growth of orthotopic human glioblastoma multiforme tumors in mice.

A potent, competitive inhibitor of HMG-CoA reductase (Ki = 2.3 nM).

Peptide affinity-purified IgG Immunogen: peptide from the C-terminal region of human MBOAT5 Host: rabbit Species Reactivity: (+) human Application(s): FC and IF

An endogenous steroid hormone that is secreted primarily by the adrenal gland and is the most abundant sex steroid; serves as an intermediate in the biosynthesis of sex steroids and directly modulates a number of cellular and nuclear receptors.

Prostacyclin is formed from arachidonic acid primarily by the vascular endothelium and renal cortex. It is a potent vasodilator and inhibitor of platelet aggregation. PGI2 is non-enzymatically hydrated to 6-keto PGF1α (t½ = 2-3 minutes), and then quickly converted to the major...

A selective cell-permeable inhibitor of non-muscle myosin II ATPases, inhibiting Mg-ATPase activity and in vitro motility of non-muscle myosin IIA and IIB for several species (IC₅₀ = 0.5-5.0 μM), while poorly inhibiting smooth muscle myosin (IC₅₀ = 80 μM).

BAM7 is a direct activator of Bax (EC₅₀ = 3.3 µM) that engages the Bax trigger site and promotes the functional oligomerization of Bax. It is selective for the BH3 binding site on Bax and does not interact with BH3 binding pockets on other proteins. BAM7 induces Bax-dependent cell...

8-hydroxy Guanine is produced by oxidative damage of DNA or RNA by reactive oxygen and nitrogen species, including hydroxyl radical and peroxynitrite. It serves as a measure of oxidative stress in biological systems.

For immunochemical detection of nitrotyrosine

(±)8(9)-EET-d11 contains 11 deuterium atoms at the 16, 16' , 17, 17' , 18, 18', 19, 19', 20, 20, and 20 positions. It is intended for use as an internal standard for the quantification of (±)8(9)-EET (Item No. 50351) by GC- or LC-mass spectrometry (MS)....

A selective inhibitor of Aurora A kinase (IC₅₀s = 1 and 1,100 nM for Aurora A and B, respectively); inhibits tumor growth in nude mice bearing Calu-6 human lung tumor xenografts at 20 mg/kg.

A lipophilic derivative of ferulic acid, with increased ability to cross cell membranes; less DPPH radical scavenging capacity than ferulic acid (IC50 = 66.7 μM for FAEE vs. 44.6 μM for ferulic acid); increases the expression of HO-1, Hsp70, and Hsp72, providing neuroprotection against amyloid...

CC-115 is a potent dual inhibitor of mTOR and DNA-PK (IC₅₀s = 22 and 15 nM, respectively). CC-115 reduces PC3 cancer cell growth in vitro (IC₅₀ = 138 nM) and exhibits effective reduction of murine PC3 tumor xenografts (mEC₅₀ = 1 mg/kg). In a Phase I clinical trial,...