(±)8(9)-EET-d11 contains 11 deuterium atoms at the 16, 16' , 17, 17' , 18, 18', 19, 19', 20, 20, and 20 positions. It is intended for use as an internal standard for the quantification of (±)8(9)-EET (Item No. 50351) by GC- or LC-mass spectrometry (MS). (±)8(9)-EET is biosynthesized from arachidonic acid in rat and rabbit liver microsomes by CYP450. (±)8(9)-EET is a major P450 metabolite in the renal cortex. (±)8(9)-EET reduces GFR through cyclooxygenase-dependent preglomerular vasoconstriction.