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Antigen: phosphopeptide corresponding to amino acid residues surrounding the phospho-Ser9 of GSK3β Host: rabbit Cross Reactivity: (+) rat GSK3β; expected to react with human, bovine, canine, chicken, mouse, non-human primate, Xenopus, and zebrafish GSK3β Application(s): WB GSK3 is a...
An analog of AEA with no intrinsic binding affinity for either CB1 or CB2 receptors; potently inhibits AEA reuptake in U937 lymphoma cells (IC50 = 3 µM); may enhance endocannabinoid signalling by augmenting endocannabinoid concentrations.
A Cdk2 inhibitor (IC50 = 0.41 μM) that demonstrates 10- to 36-fold selectivity against Cdk2-cyclin A compared to Cdk1-cyclin B, Cdk4-cyclin D, Cdk5-p25, or Cdk7-cyclin H; induces cell-cycle arrest at the G2-M phase.
An antibiotic that inhibits complex III of the mitochondrial ETC, preventing electron transport between cytochromes b and c, which results in the production of superoxide and eventual cell death; inhibits Bcl-2 and Bcl-xL proteins, inducing apoptosis.
A reactive methionine analog that contains an alkyne moiety that is readily inserted into newly-synthesized proteins; can be labeled or captured through click chemistry.
A potent inhibitor of Aurora A (IC50 = 0.064 nM) that less potently inhibits Aurora B and Aurora C (IC50s =14 and 12 nM, respectively); blocks cell cycle progression and induces apoptosis in a diverse range of human tumor types; effective in vivo.
An agonist of KCNQ channels, doubling channel currents when applied at 10 µM; serves as a centrally-acting analgesic with muscle tone-reducing activity.
An endogenous mGluR2 and mGluR3 agonist implicated in the pathophysiology of schizophrenia; induces gametogenesis of P. falciparum.
A potent and selective inhibitor of mTOR (IC50 = 2 and 10 nM for mTORC1 and mTORC2, respectively); efficacious at a dose of 20 mg/kg in inhibiting downstream effectors of mTOR in mice.
A small molecule inhibitor of nucleophosmin dimers that can prevent cell proliferation and induce apoptosis in various cancer cell lines (IC50s = 1.4-4 µM).
A cell-impermeable, negatively charged tetrazolium dye that produces a water-soluble formazan when reduced at the cell surface by cellular-derived NADH and an electron mediator.
An inhibitor of NF-κB activation with an IC50 value of 11 nM in human Jurkat cells; inhibits TNF-α production from LPS-stimulated mouse splenocytes (IC50 = 7 nM).
A naturally occurring plant sterol that inhibits the absorption of dietary and endogenously produced cholesterol from the small intestine, reducing blood cholesterol concentrations at 0.1 - 100 μM; dose dependently induces adipogenesis and lipolysis in rat primary preadipocytes; stimulates...
A synthetic peptide corresponding to the nuclear localization sequence of NF-κB p105 subunit (also known as p50) appended to a hydrophobic sequence to facilitate import into living cells; blocks the nuclear import of p105 in cells treated with activators of NF-κB signaling, including LPS...
A nonpeptidic angiotensin II receptor antagonist whose imidazo[4,5-b]pyridine scaffold has been used to examine a variety of positional substitutions in the development of orally active, long duration antihypertensive agents.
Sulfasalazine is a prodrug form of the anti-inflammatory agent 5-aminosalicylic acid (Item No. 70265) that is covalently linked to the antibiotic sulfapyridine by an azo bond.{22572} This bond is rapidly cleaved by bacteria in the terminal ileum and colon, releasing the active anti-inflammatory...
A mixture of trans (3R/7R and 3S/7S) isomers; induces the synthesis of proteinase inhibitors in plant leaves; in cancer cells, suppresses proliferation and induces apoptosis; inhibits hexokinase that is bound to mitochondria; methyl jasmonate derivatives also have potential as anti-inflammatory...
A cell-impermeant fluorescent calcium indicator that is characterized by high quantum yield and low phototoxicity.
A veterinary fluoroquinolone antimicrobial agent that inhibits bacterial DNA gyrase.
A potent and selective inhibitor of CK2 with an IC50 value of 0.3 µM and a Ki value of 0.2 µM.
A potent inhibitor of several NHE isoforms, inhibiting NHE1, NHE2, NHE3, and NHE5 with Ki values of 0.02, 0.5, 2.4, and 0.42 μM, respectively; less effectively inhibits NHE4 (IC50 ≥10 μM).
Antigen: HeLa cells transfected with human BLT1 Host: mouse, clone 7B1 Cross-Reactivity: (+) human BLT1 receptor; (−) BLT2, CysLT1, and CysLT2 receptors Application(s): FC,ICC, and IHC of frozen sections The human BLT1 receptor is a GPCR that mediates the proinflammatory effects of leukotriene...
A tricyclic antidepressant that inhibits the reuptake of serotonin and norepinephrine and acts as an antagonist at histamine, serotonin, adrenergic, and muscarinic receptors with Ki values in the nanomolar range.
A potent inhibitor of ALK (IC50 = 0.07 nM) that is less effective at IGF-1R and InsR (IC50s = 3.2 and 100 nM, respectively); drives cell death in (ALK+) Karpas-299 lymphoma cells with an IC50 value of 41.5 nM, while killing (ALK-) U937 cells with an IC50...