Cayman Chemical

Early screening of a drug candidate’s potential to induce or inhibit CYP1A1/2 is a critical step in the drug development process. Cayman's CYP1A1/2 Induction Reporter Assay Kit is a novel method to assess CYP1A2 induction. Our Reverse Transfection Reporter Assays have overcome many of the...

An inhibitor of the yeast PITP Sec14, blocking both Sec14-mediated transfer of [3H]-PtdIns in vitro and growth (IC₅₀s = 0.21 and 2.87 µM, respectively).

A natural polyamine that plays diverse roles in signal transduction and metabolism; involved in growth, development, and stress responses in plants.

A 1,3 disubstituted urea derivative of 17(R),18(S)-EpETE that is more metabolically robust and reduces the contractility of cardiomyocytes with improved potency (EC50 fold higher than required for the effect on cardiomyocytes, 1-5 μM CAY10662 exerts weak dose-dependent sEH inhibition.

A potential metabolite of 8-iso PGF2β via the 15-hydroxy PGDH pathway.

A second generation protease inhibitor that supresses the replication of various strains of HIV-1 (IC₅₀s = 3-30 nM); inhibits both cell-free diffusion and cell-to-cell spread of HIV-1 with IC₅₀ values of 2.5 and 2.8 nM, respectively.

An inhibitor of SPHK and a natural metabolite of sphingosine in some cancer cell lines and tissues; inhibits SPHK from U937 cells with a Ki value of 3.1 µM.

A potent, time-dependent, irreversible FAAH inhibitor with IC50 values of 0.6 and 0.016 µM when preincubated with recombinant human FAAH for 5 and 60 minutes, respectively.

A cell-permeable selective PDE4 inhibitor.

Intended for use as an internal standard for the quantification of diclofenac by GC- or LC-MS.

A selective CK2 inhibitor (IC50 = 1 µM) that inhibits binding of ATP with a Ki value of 0.28 µM.

A synthetic intermediate useful for pharmaceutical synthesis.

A cyclic LPA analog that contains the 16:1 fatty acid, palmitoleate, at the sn-1 position; at 25 μM inhibits the transcellular migration of MM1 cells across mesothelial cell monolayers without affecting proliferation; significantly inhibits autotaxin (IC50 = 620 nM).

Ebselen acts as a glutathione peroxidase mimic and is an excellent scavenger of peroxynitrite with a rate constant of 2 x 106 M−1s−1. The glutathione peroxidase-like activity of ebselen inhibits cyclooxygenase and lipoxygenases at micromolar concentrations.

A LTB4 receptor antagonist that has a higher binding affinity for BLT1 (Ki = 27 nM) compared to BLT2 (Ki = 473 nM); inhibits LTB4-induced release of lysozymes from rat polymorphonuclear leukoctyes with an IC₅₀ value of 1 µM.

Antigen: human EP4 receptor C-terminal amino acids 459-488 Host: rabbit Cross Reactivity: (+) human, mouse, ovine, and rat EP4 receptors; (−) EP1, EP2, and EP3 receptors Application(s): ICC, IHC, and WB Binding of PGE2 to the EP4 receptor causes an increase in intracellular cyclic AMP and...

A non-cholestatic regioisomer of E217G that acts as a substrate for MRP2, competing with E217G for MRP2-mediated transport (IC₅₀ = 14.2 µM).

A rotenoid compound with chemopreventive and chemosensitizing effects in models of skin, mammary, colon, and lung carcinogenesis; inhibits cell growth (IC50 = 8 M), blocks PI3K/Akt signaling, suppresses COX-2 expression, and induces apoptosis of premalignant and squamous HBE cells without affecting...

Butaprost is a structural analog of PGE2 with good selectivity for the EP2 receptor subtype. Butaprost has frequently been used to pharmacologically define the EP receptor expression profile of various human and animal tissues and cells.{3317} Serious confusion as to the structure of butaprost was...

11-deoxy PGF1α is a synthetic analog of PGF1α. In whole animal studies, a dose of 32 mg/kg inhibited gastric acid secretion by 35%. 11-deoxy PGF1α is also known to cause rat uterine contractions at a dose 0.3 times that of PGF1α. It also exhibits vasopressor and...

A conjugated form of trimethoprim linked with polyethylene glycol (PEG) amine.

A first generation histamine H1 receptor antagonist (Ki = 2.6 nM) that also inhibits muscarinic acetylcholine receptors (Ki = 22 nM); penetrates the CNS, depressing central H1 receptor activity, which may relate to its sedative properties.

A potent inhibitor of human SGLT2 that is 1,000-fold less potent at human SGLT1 (Ki values are 2 and 25,000 nM, respectively); dissociates from hSGLT2 more slowly than from hSGLT1 (half-time off rates are 19 and 0.9 seconds, respectively).

Diethylstilbestrol (DES) is a synthetic estrogen receptor agonist that was prescribed to pregnant women in the late 1930s. It was banned in 1971 because of possible links to increased risk of breast cancer in mothers along with congenital abnormalities and increased risk of cancer in offspring. DES...