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An enantiomer of the short-lived oral anti-coagulant acenocoumarol with a shorter plasma elimination half-life (1.8 hours) and faster plasma clearance (28.5 L/hour), compared to the (R)-enantiomer (6.6 hours, 1.9 L/hour); undergoes extensive first-pass metabolism during absorption from the...
A potent, selective, and orally bioavailable inhibitor of PI3Kγ and PI3Kδ (IC50s = 0.24 and 50 nM, respectively); has profound effects in collagen-induced and adjuvant-induced arthritis, ovalbumin-induced asthma, and systemic lupus erythematosus animal models.
A single purified isomer of conjugated linoleic acid which consists of a family of eight geometric isomers of linoleic acid.
A natural monocyclic sesquiterpene that potently inhibits the activation of Epstein-Barr virus by phorbol esters (IC50 = 140 nM); inhibits SHH signaling and induces apoptosis in cancer cell lines.
FFAR1/GPR40 is a G protein-coupled receptor for long-chain fatty acids such as DHA and EPA ω-3 fatty acids. It is involved in the regulation of insulin release from pancreatic β cells and mediates triglyceride-induced secretion of incretins GLP-1 and GIP from intestinal endocrine cells....
Antigen: human ApoA1 amino acids 188-199 Host: mouse, clone CC3821C4 Cross Reactivity: (+) human ApoA1, (−) ApoB Application(s): WB ApoA1 is a major protein component of HDL. It acts as an acceptor for sequential transfers of phospholipids and free cholesterol from peripheral tissues and...
A dihydroxybenzoic acid phenolic compound that demonstrates free radical scavenging capability (IC50 = 16.3 μM) in a DPPH radical scavenging activity assay; possesses anti-inflammatory, antihyperglycemic, neuroprotective, and anticancer activities.
A reversible inhibitor of the cis-Golgi ArfGEF, GBF1 (IC50 = 3.3 µM); induces rapid dissociation of COPI vesicle coat protein from Golgi membranes and disassembly of the Golgi and trans-Golgi network, preventing bidirectional transport of endocytic cargo.
Blocks mitochondrial complex III; inhibits the activity of the NADH oxidase in certain bacteria.
A 2-thiazolylhydrazone derivative that, at 10 µM, improves nuclear architecture, chromatin organization, and survival of both cells lacking lamin A and cells from patients with progeria; inhibits NAT10.
A bioactive macrolide derived from sponges that binds monomeric actin, preventing actin polymerization both in vitro (Kd = 0.2 μM) and in cells (0.5 μM).
An internal standard for the quantification of ±11(12)-EET by GC- or LC-MS.
A synthetic intermediate that has been used to design novel antitumor compounds.
A synthetic intermediate useful for pharmaceutical synthesis.
An antioxidant and free radical scavenging compound extracted from S. miltiorrhiza that has been investigated for its cardioprotective and chemopreventative properties.
A potent, reversible, ATP-competitive, and selective inhibitor of the Src family of protein tyrosine kinases: p56lck (IC50 = 5 nM), p59fynT (IC50 = 6 nM), Hck (IC50 = 20 nM).
CAS Number: 701213-36-7 Synonyms: Temsavir Molecular Formula: C24H23N7O4 Formula Weight: 473.5
6-piperazin-1-yl-Isoquinoline (hydrochloride) is a synthetic intermediate useful for pharmaceutical synthesis.
A potent inhibitor of FTase, blocking farnesylation of H-Ras, N-Ras, and K-Ras4B with IC50 values of 0.8, 1.2, and 2.0 nM, respectively; displays over 50,000-fold selectivity for FTase over geranylgeranyltransferase I.
An analog of resveratrol that acts as a potent and selective AhR agonist (Ki = 0.2 nM)
A potent antagonist of the TXA2 receptor, blocking specific binding of U-46619 to platelets with an IC50 value of 7.4 nM and platelet aggregation induced by U-44069 with an IC50 value of 350 nM; commonly used to study the roles of the TP receptor in animal airways and in tissue...
A metabolite of epinephrine produced by the action of catechol-O-methyl transferase on epinephrine; detection is used in the clinical diagnosis of pheochromocytoma.
2-(hydroxymethyl)-Pyrimidine is a synthetic intermediate useful for pharmaceutical synthesis.
A dual inhibitor of c-Src and Abl (IC50 = 2.7 and 30 nM, respectively); less effectively inhibits other kinases; blocks cell motility, migration, adhesion, invasion, proliferation, differentiation, and survival; reduces osteoclast bone resorption.