Cayman Chemical

An irreversible tripeptide inhibitor of all caspases; useful in studies involving recombinant, isolated, or purified enzymes.

This nuclear receptor assay system utilizes a proprietary rodent cell line that is further engineered to express the mouse/rat peroxisome proliferator-activated receptor gamma (NR1C3, PPARG). Because the receptor’s ligand binding domain sequence is conserved between mouse and rat species, the...

Reversible, selective inhibitor of cPLA2 with an IC₅₀ value of 4.2 nM in enzyme assays; potently blocks the release of AA and the production of PGE2 and LTC4 in cells (IC₅₀ = 24, 25, and 14 nM, respectively).

11-deoxy PGE2 is a stable, synthetic analog of PGE2. In contrast to PGE2 which has bronchodilation effects, 11-deoxy PGE2 is a powerful bronchoconstrictor and is 5 to 30 times more potent than PGF2α in the contraction of human respiratory tract smooth muscle in vitro.

Precursor of PEA, an endogenous CB found in brain, liver, and other mammalian tissues; PEA has potent anti-inflammatory activity in vivo.

A common C-12 saturated far plentiful in coconut and other nut oils.

An analytical reference material categorized as a phytocannabinoid; intended for research and forensic applications

2-fluoro Palmitic acid inhibits sphingosine biosynthesis and long-chain acyl-CoA synthetase with an IC₅₀ value of 0.2 mM.

A carboxylic acid-based inhibitor of aldose reductase (IC₅₀ = 0.01-15 μM) that suppresses high glucose-induced proliferation of vascular smooth muscle cells as well as prevents high glucose-induced intracellular NADH/NAD+ increase and membrane-bound protein kinase C activation.

N-2PIA is one of several aromatic amides of indomethacin reported to be potent and selective reversible inhibitors of COX-2. N-2PIA inhibits human recombinant and ovine COX-2 with IC₅₀ values of 0.06 and 0.125 µM, respectively. It is over 400 times less potent as an inhibitor of...

C-8 ceramide is a cell-permeable analog of naturally occurring ceramides. Unlike C-2 ceramide, it is metabolized within cells to generate natural ceramides, often causing a dramatic increase in cellular ceramide levels. For this reason, treatment of cells with C-8 ceramide may more closely mimic the...

A time-dependent, non-specific COX inhibitor with IC₅₀ values of 1.5 and 9.7 µM for human recombinant COX-1 and COX-2, respectively.

An AEA transport inhibitor with essentially no activity on the CB1 receptor, CB2 receptor, or TRPV1; inhibits FAAH and MAGL and may act as an alternative FAAH substrate; inhibits glutamergic synaptic transmission between hippocampal neurons at a concentration of 3 µM.

A dihydropyridine L-type calcium channel antagonist that displays antihypertensive and antianginal activity; selectively inhibits adenosine A3 receptors (Ki = 3.25 µM) and CYP3A4 catalytic activity (IC₅₀ = 0.148 µM); activates TRPA1 channels, producing an increase in Ca2+...

An affinity probe which allows 8-iso PGA2 to be detected through an interaction with the biotin ligand.

Limaprost is an analog of PGE1 with structural modifications intended to give it a prolonged half-life and greater potency. Limaprost is an inhibitor of ADP and collagen-induced platelet aggregation and is 10-1,000 times more potent than PGE1 as an inhibitor of platelet adhesiveness measured in...

A selective antagonist of the EP2 receptor, suppressing PGE2-induced elevation of cAMP in cells expressing EP2 with an IC₅₀ value of 1.6 µM; reduces the expression of COX-2, IL-1β, IL-12, IL-23, IL-6, and TNF-α induced by the EP2-selective agonist butaprost in P388D1...

Non-denaturing detergent used to solubilize and reconstitute membrane-bound proteins; characterized by a high critical micelle concentration (0.7%) which facilitates ready removal from final protein extracts.

A fluorescent calcium indicator that displays a low affinity for calcium (Kd = 42 µM).

A selective, cell-active inhibitor of NOX1 that blocks the generation of ROS in HT-29 cells (IC₅₀ = 0.129 µM); abolishes collagen-induced superoxide production by platelets (IC₅₀ = 306 nM).

A DCA trimer that is at least 10-fold more cytotoxic against leukemia cell lines than DCA; significantly reduces both basal and maximal respiration in leukemia cells.

An orally bioavailable Smac/DIABLO mimetic and antagonist of IAPs (Kis = 66.4, 1.9, and 5.1 nM for XIAP, cIAP1, and cIAP2, respectively); inhibits cancer cell growth in various human cancer cell lines and induces apoptosis in xenograft tumors in mice.

A synthetic analog of curcumin that activates enzymes which catalyze detoxification reactions through the Keap1-Nrf2-ARE pathway; increases NQO1 activity, glutathione reductase activity, and total glutathione levels in vitro at 0.6 – 0.15 μM; causes G2/M cell cycle arrest and...

A more lipid soluble, prodrug formulation of LXA4.