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The active metabolite of oxcarbazepine that demonstrates anticonvulsant efficacy by inhibiting both voltage-gated Na+ and Ca2+ channels, potentiating voltage-gated K+ channels, antagonizing adenosine A1 receptors, increasing dopaminergic transmission, and inhibiting glutamate release.
A latanoprost-related isomer containing both a double bond at C-13,14 and an invered (b) hydroxyl group at C-15; a potential impurity in most commercial preparations of the lantanoprost bulk drug product.
A member of the family of fatty N-acyl ethanolamines collectively called endocannabinoids.
FAAH is a cytosolic serine hydrolase responsible for the degradation of fatty acid amides, including AEA. Finding inhibitors to FAAH could offer a beneficial approach toward the treatment of pain, obesity, and various neurological diseases where higher endocannabinoid activity would be beneficial....
Molecular Formula: C16H28N2O4S2
A plant growth regulator that activates various signal transduction pathways with both growth promoting and inhibitory functions, perhaps in response to stress; initially synthesized as (+)7-epi jasmonic acid, a more active and biologically relevant form of the hormone, but quickly epimerizes to the...
Selective and irreversible dual inhibitor of EGFR and HER2 kinase activity (IC50s = 0.5 and 14 nM, respectively); suppresses transformation in isogenic cell-based assays, inhibits survival of cancer cell lines, and at 20 mg/kg, induces tumor regression in xenograft and transgenic lung cancer models.
A potent, selective antagonist of the H1 histamine receptor (Ki = 16-41.1 nM), with much lower affinities for the H2 and H3 receptors (Ki = 43.4 and 172 μM, respectively); effective in treating allergic rhinitis and conjunctivitis; does not cause cognitive or psychomotor impairment at therapeutic...
Latanoprost is an F-series prostaglandin analog which has been approved for use as an ocular hypotensive drug. Latanoprost lactol is an intermediate in the synthesis of latanoprost. Latanoprost lactol can be converted to the free acid of latanoprost by Wittig reaction with commercially available...
This nuclear receptor assay system utilizes proprietary non-human cells engineered to provide constitutive, high-level expression of the human peroxisome proliferator-activated receptor delta (NR1C2), a ligand-dependent transcription factor commonly referred to as PPARD or PPARδ....
Cayman's 8-Hydroxyguanosine (8-OHG) ELISA Kit is a competitive assay that can be used to measure both 8-hydroxy-2'-deoxyguanosine and 8-hydroxyguanosine. This kit has been validated for use in urine, but other sample types may be used. The assay has a range from 0.15-20 ng/ml and a...
A natural anthraquinone with antibacterial, antiviral, anti-inflammatory, and anticancer activity in various research models; inhibits hepatitis B viral DNA production; diminishes the expression of iNOS and COX-2; induces necrosis in cancer cells.
An Mcl-1 inhibiting molecule.
An internal standard for the quantification of oleoyl serotonin by GC- or LC-MS.
A DHA (Item No. 90310) metabolite, derived via epoxidation of the ω-3 double bond of DHA; epoxygenase metabolites of DHA have been detected in a mouse model of inflammation.
Formal Name: 2-(acetylamino)-2-deoxy-3-O-methyl-D-glucose Synonyms: 3-OMe-GlcNAc Molecular Formula: C9H17NO6 Formula Weight: 235.2
A muscarinic receptor agonist (EC50s = 23, 48, and 63 nM for M1, M3, and M5, respectively, and >1 µM for M2 and M4); stimulates secretion by salivary glands and is useful in ameliorating xerostomia (dry mouth).
A metabolite of PGE1 with significantly reduced biological activity.
A dual agonist of PPARα and PPARγ (EC50s = 320 and 110 nM in vitro); improves diabetes and other metabolic abnormalities while preserving β-cell function in db/db mice.
A FAHFA consisting of stearic acid esterified to 13-hydroxy stearic acid.
An orally bioavailable prodrug of AZD 1152-HQPA, a selective inhibitor of Aurora kinase B (IC50 = 0.36 nM).
Cayman’s Cell Cycle Phase Determination provides an easy to use tool for studying the induction and inhibition of cell cycle progression in any cell suspension sample. The assay involves the fixation and permeabilization of the cells of interest, making possible the staining of DNA within...
One of four major analogs in the enniatin complex that has been shown to moderately inhibit ACAT activity in rat liver microsomes (IC50 = 22 µM); demonstrates anthelmintic properties against N. brasiliensis, T. spiralis, and H. spumosa.