Cayman Chemical

A bacterial pyridone metabolite that inhibits NOS activity, with selectivity for NOS III (eNOS) over NOS I (nNOS).

An inactive analog of the Src tyrosine kinase inhibitors PP1 and PP2.

A natural flavonol and potent antioxidant with anti-inflammatory actions; activator of sirtuin 1, inhibitor of the spleen tyrosine kinase SYK, and suppressor of CD36 gene expression.

A member of the inositol phosphate molecular family of second messengers that play critical roles in intracellular signaling.

An inhibitor of class III receptor tyrosine kinases (IC₅₀s = 0.3 µM for c-Fms, c-Kit, ITD-FLT3 and 1 µM for PDGFRβ); blocks the proliferation of leukemia cells stimulated with FLT3 ligand by preventing the activation of STAT5.

A synthetic analog of PEA which incorporates an (R)-methyl group vicinal to the alcohol on the ethanolamine moiety, which may protect the molecule from enzymatic hydrolysis, leading to prolonged duration of action and enhanced potency in vivo; expected to show enhancement of the inhibitory activity...

The less predominant-occurring (~20%) stereoisomer of the endogenous oxysterol 27-hydroxy cholesterol.

azido-FTY720 is a highly photoreactive analog of FTY720 that can be used to identify receptor binding sites for this ligand.

A potent, selective, and orally bioavailable inhibitor of HIV integrase (IC₅₀ = 15 nM); metabolized primarily by uridine diphosphate glucuronosyltransferase 1A1.

A cell-permeable triaminopyrimidine that selectively and reversibly blocks Cdk4/cyclin D1 and Cdk6/cyclin D1 activity (IC₅₀s = 1.5 and 5.6 μM, respectively); induces cell cycle arrest in the G1 phase and apoptosis in asynchronous cell lines; suppresses tumor growth in mice bearing...

An internal standard for the quantification of oleic acid by GC- or LC-MS.

An inhibitor of SAH hydrolase (Ki = 3.9 μM); has anti-inflammatory, anti-viral, and anti-bacterial activities.

Inhibits PTEN activity (IC₅₀ = 2 μM), increasing cellular PIP3 levels, phosphorylation of Akt, and glucose uptake in adipocytes; used to enhance PIP3 signaling in transplanted neutrophils.

One of the oxLDL species derived from 2-arachidonoyl or eicosapentanoyl phospholipids; confers CD36 scavenger receptor binding affinity of oxLDL.

A potent and selective competitive antagonist of the P2X₇ receptor.

An analog of wortmannin; irreversibly binds PI3K; inhibits recombinant PI3K and mTOR (IC₅₀ = 2.7 and 193 nM, respectively) and prevents the growth of LNCap cells (IC₅₀ = 1.46 μM).

A potent and selective AhR antagonist with a Ki value of 1.4 nM when tested in rabbit liver cytosol preparations.

The major CYP3A4 metabolite of amiodarone; used as an analytical reference standard for monitoring clinical efficacy of amiodarone in plasma samples.

An endocannabinoid containing α-linolenic acid in place of the arachidonate moiety of AEA; detected in porcine brain, but its specific role and relative importance as a cannabinergic neurotransmitter have not been elucidated.

An unsaturated short chain fatty acid that is secreted by P. aeruginosa and induces a dispersion response in biofilms formed by gram-negative and gram-positive bacteria, as well as by the yeast C. albicans; promotes dispersion of P. aeruginosa biofilms over a concentration range of 1.0 to 10 nM.

A potent agonist of D₂ receptors.

.delta.-CEHC is a major β-oxidation metabolite of .delta.-tocopherol. Approximately 50% of a 3H-.delta.-tocopherol given as an intraperitoneal dose in rat is recovered in the urine as .delta.-CEHC, indicating this is the major route of metabolism.

A cytotoxic Streptomyces metabolite that inhibits topoisomerase II and hepatitis C viral replication.

A cytotoxic, quinoline alkaloid that inhibits the DNA enzyme topoisomerase I (Top I) by binding the Top1-DNA cleavage complex and inducing DNA-strand breaks; has strong anti-tumor activity and induces DNA damage at concentrations as low as 51 nM in whole cells and 12 nM in isolated nuclei in in...