Cayman Chemical

Cayman’s Cell Cycle Phase Determination provides an easy to use tool for studying the induction and inhibition of cell cycle progression in any cell suspension sample. The assay involves the fixation and permeabilization of the cells of interest, making possible the staining of DNA within...

One of four major analogs in the enniatin complex that has been shown to moderately inhibit ACAT activity in rat liver microsomes (IC₅₀ = 22 µM); demonstrates anthelmintic properties against N. brasiliensis, T. spiralis, and H. spumosa.

A bacterial pyridone metabolite that inhibits NOS activity, with selectivity for NOS III (eNOS) over NOS I (nNOS).

An inactive analog of the Src tyrosine kinase inhibitors PP1 and PP2.

A natural flavonol and potent antioxidant with anti-inflammatory actions; activator of sirtuin 1, inhibitor of the spleen tyrosine kinase SYK, and suppressor of CD36 gene expression.

A member of the inositol phosphate molecular family of second messengers that play critical roles in intracellular signaling.

An inhibitor of class III receptor tyrosine kinases (IC₅₀s = 0.3 µM for c-Fms, c-Kit, ITD-FLT3 and 1 µM for PDGFRβ); blocks the proliferation of leukemia cells stimulated with FLT3 ligand by preventing the activation of STAT5.

A synthetic analog of PEA which incorporates an (R)-methyl group vicinal to the alcohol on the ethanolamine moiety, which may protect the molecule from enzymatic hydrolysis, leading to prolonged duration of action and enhanced potency in vivo; expected to show enhancement of the inhibitory activity...

The less predominant-occurring (~20%) stereoisomer of the endogenous oxysterol 27-hydroxy cholesterol.

azido-FTY720 is a highly photoreactive analog of FTY720 that can be used to identify receptor binding sites for this ligand.

A potent, selective, and orally bioavailable inhibitor of HIV integrase (IC₅₀ = 15 nM); metabolized primarily by uridine diphosphate glucuronosyltransferase 1A1.

A cell-permeable triaminopyrimidine that selectively and reversibly blocks Cdk4/cyclin D1 and Cdk6/cyclin D1 activity (IC₅₀s = 1.5 and 5.6 μM, respectively); induces cell cycle arrest in the G1 phase and apoptosis in asynchronous cell lines; suppresses tumor growth in mice bearing...

An internal standard for the quantification of oleic acid by GC- or LC-MS.

An inhibitor of SAH hydrolase (Ki = 3.9 μM); has anti-inflammatory, anti-viral, and anti-bacterial activities.

Inhibits PTEN activity (IC₅₀ = 2 μM), increasing cellular PIP3 levels, phosphorylation of Akt, and glucose uptake in adipocytes; used to enhance PIP3 signaling in transplanted neutrophils.

One of the oxLDL species derived from 2-arachidonoyl or eicosapentanoyl phospholipids; confers CD36 scavenger receptor binding affinity of oxLDL.

A potent and selective competitive antagonist of the P2X₇ receptor.

An analog of wortmannin; irreversibly binds PI3K; inhibits recombinant PI3K and mTOR (IC₅₀ = 2.7 and 193 nM, respectively) and prevents the growth of LNCap cells (IC₅₀ = 1.46 μM).

A potent and selective AhR antagonist with a Ki value of 1.4 nM when tested in rabbit liver cytosol preparations.

The major CYP3A4 metabolite of amiodarone; used as an analytical reference standard for monitoring clinical efficacy of amiodarone in plasma samples.

An endocannabinoid containing α-linolenic acid in place of the arachidonate moiety of AEA; detected in porcine brain, but its specific role and relative importance as a cannabinergic neurotransmitter have not been elucidated.

An unsaturated short chain fatty acid that is secreted by P. aeruginosa and induces a dispersion response in biofilms formed by gram-negative and gram-positive bacteria, as well as by the yeast C. albicans; promotes dispersion of P. aeruginosa biofilms over a concentration range of 1.0 to 10 nM.

A potent agonist of D₂ receptors.

.delta.-CEHC is a major β-oxidation metabolite of .delta.-tocopherol. Approximately 50% of a 3H-.delta.-tocopherol given as an intraperitoneal dose in rat is recovered in the urine as .delta.-CEHC, indicating this is the major route of metabolism.