Cayman Chemical

A macrolide antibiotic that shows good bactericidal activity against MRSA.

This nuclear receptor assay system utilizes proprietary non-human cells engineered to provide constitutive high-level expression of full-length, unmodified human mineralocorticoid receptor (NR3C2), a ligand-dependent transcription factor commonly referred to as MR. INDIGO’s reporter cells...

An HDAC inhibitor, antitumor agent that at 10 μM can induce oxidative stress contributing to apoptosis and differentiation in MCF-7 breast cancer cells; inhibits T. gondii tachyzoite propagation in human fibroblasts (EC₅₀ = 80 nM) and inhibits P. falciparum growth in human red blood...

Source: Active recombinant GST-tagged protein expressed in E. coli Mr: ~40 kDa pCAF belongs to the GCN5/pCAF family of nuclear HATs. Cayman’s pCAF preparation contains 165 amino acids from the HAT activity domain of human pCAF fused to GST at the N-terminus. Enzyme activity was determined...

COX-1 and COX-2 catalyze the production of the PG and TX precursor PGH2. COX-2 is primarily responsible for the biosynthesis of PGs under acute inflammatory conditions. The COX-1 (ovine) Inhibitor Screening Assay measures PGF2α that is produced by SnCl2 reduction of COX-1-derived PGH2....

A synthetic analog of 17β-estradiol

Antigen: human recombinant MCAD Host: rabbit Cross Reactivity: (+) human, porcine, ovine, and mouse MCAD; other species not tested Application(s): WB; other applications not tested MCAD is a mitochondrial enzyme that catalyzes the first step in the β-oxidation of fatty acids. Its expression is...

A 2,6,9-trisubstituted purine that promotes the differentiation of both human and mouse mesenchymal progenitor cells into osteoblasts; binds to and activates the 7-transmembrane Smo receptor of the Hedgehog signaling pathway.

A potent RSK2 inhibitor (IC₅₀ = 1.1 nM) that also demonstrates off-target binding at multiple adrenergic receptor subtypes that are important for vascular tone and cardiac function (IC₅₀s = 0.052-1.820 μM for adrenergic ?1A, ?1B, ?1D, ?2A, β2, and imidazoline I2...

An ATP-competitive, allosteric inhibitor of IRE1α RNase kinase activity (IC₅₀ = 0.6 µM); prevents IRE1α oligomerization and promotes cell survival under ER stress in rat models of retinal degeneration and diabetes.

A selective inhibitor of TAF1 bromodomain 2 (Kd = 1.8 µM; IC₅₀ = 0.9 µM); synergizes with (+)-JQ1 to inhibit the proliferation of THP-1 and H23 lung adenocarcinoma cells.

A potent inhibitor of PORCN (IC₅₀ = 74 pM), completely blocking Wnt secretion into culture media; prevents activation of all evaluated Wnt family members; effective in vivo as well as in vitro; blocks the progression of breast cancer while downregulating Wnt/β-catenin pathway target...

A prodrug for the potent PGE2 analog 15(S)-15-methyl PGE2 designed for activation by gastric acid after oral administration.

A potent inhibitor of VEGF receptors, inhibiting VEGFR1, 2, and 3 with IC₅₀ values of 130, 23, and 18 nM, respectively; orally bioavailable in vivo, blocking VEGF-induced angiogenesis and preventing the growth of primary tumors and spontaneous peripheral metastases in mice.

A second-generation analog of (R)-roscovitine that inhibits Cdk1, 2, 5, and 9 (IC₅₀s = 0.09, 0.072-0.041, 0.11, and 0.18 μM, respectively) with improved potency over its parent compound; also inhibits CK1δ/ε (IC₅₀ = 0.40 μM) and GSK-3α/β...

A macrolide antibiotic that inhibits bacterial protein synthesis (IC₅₀ = 0.26 µM) by targeting the 50S ribosomal subunit; effective against M. haemolytica and P. multocida (MICs = 2 and 0.5 µg/ml, respectively), which cause respiratory tract infections in cattle and swine.

A potent antagonist of the type III receptor tyrosine kinases PDGFRβ, FLT3, and c-Kit (IC₅₀ = 200, 220, and 170 nM, respectively); less potently inhibits CSF-1R (IC₅₀ = 3.4 µM) and does not significantly inhibit other tyrosine or serine/threonine kinases.

An internal standard for the quantification of creatinine by GC- or LC-MS.

A selective, potent inhibitor of ERK2 (Ki = 2 nM); inhibits proliferation of COLO 205 cells (IC50 = 0.54 µM).

A major inactive metabolite of clopidogrel that is used as a reference standard for quantitative analysis of clopidogrel metabolism.

A cell permeable, selective inhibitor of μ-calpain (calpain-1) and m-calpain (calpain-2); crosses the blood-brain barrier to inhibit brain cysteine protease activity; reported to have protective effects in numerous rodent models of neurotrauma and cardiac ischemia.

A brominated derivative of cAMP that remains long-acting due to its resistance to degradation by cAMP phosphodiesterase; activates cAMP-dependent protein kinase, inhibiting growth, decreasing proliferation, increasing differentiation, and inducing apoptosis of cancer cells.

An analog of the endocannabinoid AEA found in brain tissue and in chocolate whose biosynthesis is reduced in the intestine of rats following food deprivation; an endogenous, potent agonist for PPARα (EC₅₀ = 120 nM in a transactivation assay); systemic administration suppresses food...

An orally bioavailable iron chelator that binds to iron in a 3:1 (ligand:iron) molar ratio.