Cayman Chemical

6-keto prostaglandin F_1α (6-keto PGF_1α) is the inactive, non-enzymatic hydrolysis product of PGI₂. 6-keto PGF_1α serves as a useful marker of PGI₂ biosynthesis in vivo. When [ 3 H]-PGI₂ is injected into healthy human...

A TP receptor antagonist that shows ~20-fold selectivity for TPβ (IC₅₀ = 99 nM) relative to TPα (IC₅₀ = 1,970 nM) in the inhibition of U-46619-mediated Ca2+ mobilization.

A microbial metabolite that binds the TCR on Vγ9Vδ2 peripheral blood lymphocytes with high affinity (EC50 = 0.39 nM); induces the expansion of human memory Vγ9Vδ2 T cells.

A stable, cell-permeable molecule which generates free glutamic acid upon hydrolysis of the ester bond by cytoplasmic esterases; used in experiments to increase levels of cytoplasmic glutamic acid; also used to synthesize 5-octyl ester derivatives, including 5-octyl α-ketoglutarate, for...

A naturally-occurring isoflavone with anti-oxidant, anti-carcinogenic, and anti-atherosclerotic activities; directly inhibits mitochondrial aldehyde dehydrogenase 2 (IC₅₀ = 80 nM) and is an effective anti-dipsotropic isoflavone.

An antibiotic that acts as a prodrug that is converted to isonicotinic acyl-NADH complex, which inhibits mycolic acid biosynthesis; effective against several species of Mycobacterium, including M. tuberculosis.

A major phytotoxin that acts as a virulence factor in the common scab potato disease; demonstrates herbicidal activity against dicotyledon weeds B. campestris and A. retroflexus.

A synthetic intermediate for pharmaceutical synthesis.

A naturally produced dietary fiber that is sometimes categorized as a prebiotic; used to measure kidney function by determining the glomerular filtration rate.

A widely-used fluorescent indicator for estimating intracellular pH; amenable to either spectrofluorometry or flow cytometry; can also be used to investigate intracellular changes in other ions, including potassium.

An inhibitor of DGK (IC₅₀ = 2.8 µM), increasing DAG-dependent PKC activity; blocks vascular contraction induced by U-46619 (Item No. 16450); induces apoptosis in glioblastoma cells without being toxic to non-cancerous cells; inhibits A. thaliana DGK2 (IC₅₀ = 50 µM)...

Nitrotyrosine BSA is a positive control for detection of protein tyrosine nitration by WB using nitrotyrosine antibodies.

A water-soluble receptor antagonist which targets both AMPA- and kainate-sensitive glutamate receptors (IC₅₀ = 0.15 and 4.8 µM, respectively); does not block the NMDA-sensitive glutamate receptor (IC₅₀ = ≥ 90 µM).

A synthetic peptide corresponding to an amino acid sequence found in the amino terminal C2 domain of most mammalian forms of PKC?; selectively and reversibly inhibits the translocation of PKC? to intracellular membranes, blocking activation.

Source: Active recombinant N-terminal Strep II-tagged protein expressed in E. coli Mr: 42.7 kDa JMJD2A catalyzes the demethylation of trimethylated forms of histone at lysine residues 9 and 36. JMJD2A is an α-ketoglutarate-dependent Fe (II) oxygenase. Purification of Fe-dependent JmjC family...

A natural analog of 20-hydroxyecdysone and agonist of the ecdysteroid receptor (Kd = 1 nM); used as an agonist in ecdysone-inducible gene expression systems in mammalian cells.

A non-steroidal antiandrogen that binds the androgen receptor (Ki = 12.5 μM; IC₅₀ = 1.2 μM), preventing its activation and subsequent upregulation of androgen responsive genes by androgenic hormones.

α-ESA ethyl ester is a neutral, more lipid soluble form of the free acid.

A cell-permeable, fluorescent probe for the detection and bioimaging of NO (ex. max 495 nm/em. max 515 nm).

Antigen: human S1P3 amino acids 12-25 Host: rabbit Cross Reactivity: (+) human, mouse, and rat S1P3 Application(s): ICC and WB S1P3 is one of five GPCRs that are activated by S1P. It couples to Gi/o-ERK, Gq-PLC, and G12/13-Rho axes to mediate S1P-induced cell proliferation, survival, migration, and...

A natural type B trichothecene produced by certain species of the fungus Fusarium; inhibits protein biosynthesis, binds to peptidyl transferase, and inhibits the synthesis of RNA and DNA; passes the blood-brain barrier at different rates in different animals.

A photosensitizer used during photodynamic therapy to eliminate abnormal blood vessels in the eye that are associated with conditions such as macular degeneration; also inhibits autophagosome formation by directly targeting and modifying p62, a scaffold and adaptor protein that binds both...

Cayman’s Protein Carbonyl Colorimetric Assay is a colorimetric assay for the measurement of oxidized proteins. The carbonyls of protein samples are derivatized using 2,4-dinitrophenylhydrazine. Formation of a Schiff base produces the corresponding hydrazone which can be analyzed...

A cardenolide and aglycone constituent of digitoxin that elicits cardiac contraction and cardiotonic effects by inhibiting the Na+/K+ ATPase; inhibits protein synthesis and has been examined for use as an antitumor compound.