Cayman Chemical

A cardenolide and aglycone constituent of digitoxin that elicits cardiac contraction and cardiotonic effects by inhibiting the Na+/K+ ATPase; inhibits protein synthesis and has been examined for use as an antitumor compound.

A platinum-containing compound that acts as an alkylating agent; used alone or in combination therapy in the treatment of several types of cancer; inhibits the RecA recombinase of M. tuberculosis (IC₅₀ = 2 µM), blocking protein splicing and cell growth.

A pyrimidine nucleoside used in epigenetics research to investigate the dynamics of DNA methylation pattern in the control of gene expression.

A covalent Cdk7 inhibitor (IC₅₀s = 3.2-15.6 nM in vitro) that displays broad anti-proliferative activity against cancer cell lines, particularly T-ALL cell lines with characteristic misregulation of T cell lineage-specific transcription factors.

An immunomodulatory compound that inhibits inflammatory antigen presentation both in vitro and in preclinical in vivo models of autoimmune diseases; targets macrophages, reducing the production of the proinflammatory mediators TNF-α, IL-1β, macrophage migration inhibitory factor, and...

A membrane-impermeant lidocaine derivative that when combined with capsaicin selectively blocks sodium channels on nociceptive neurons via the TRPV1 channel; decreases the pain response without imparting numbness or paralysis associated with other local anesthetics.

An antagonist of the endothelin receptors type A (Ki = 6.5 nM) and type B (Ki = 340 nM); used, alone or in combination therapy, in the treatment of pulmonary arterial hypertension.

Full-length mature apelin peptide; acts primarily in the regulation of cardiovascular function, fluid homeostasis, hypertension, and insulin sensitivity; a less potent APJ agonist than either apelin-17 or apelin-13 (EC50 = 20, 2.5, and 0.37 nM, respectively); potently inhibits HIV-1 entry into cells...

Features Each vial contains a mixture of standards packaged in amber ampules purged with argon >1 ml provided at the concentration specified in the insert Designed for direct snap and inject use in mass spectrometry applications Ideally suited for method development and as a system suitability...

An inhibitor of EGF receptor kinase with an IC50 value of 1 µM in HT-22 cells.

A weak inhibitor of PKC demonstrating an IC₅₀ value >100 µM; blocks the activation of mitogen-stimulated protein kinase p70s6k/p85s6k (S6K) in vivo with an IC₅₀ value of 8 µM.

This nuclear receptor assay system utilizes proprietary non-human cells engineered to provide constitutive, high-level expression of the rat peroxisome proliferator-activated receptor delta (NR1C2), a ligand-dependent transcription factor commonly referred to as PPARD or rPPARδ. INDIGO’s...

A synthetic peptide derivative that irreversibly and specifically inhibits thrombin-mediated platelet activation by binding with high affinity to the active site of thrombin (Ki = 0.24 nM); used as an anticoagulant (100 μM).

An orally available activator of mutant forms of p53; induces apoptosis in a wide variety of human tumor cells in culture, inhibits the proliferation of colorectal cancer cell lines, and is active against human glioblastoma cell lines at nanomolar concentrations.

A glycerol ester analog of 15-deoxy-Δ12,14-PGJ2; there are no publications on its biological activity.

15-deoxy-.DELTA.12,14-PGD2 is a synthetic analog of PGD2 and a potential precursor to the PPARγ ligand 15-deoxy-.DELTA.12,14-PGJ2. It possesses cytotoxic effects on L1210 mouse leukemia cells in vitro with an IC₅₀ of 0.3 µg/ml. 15-deoxy-.DELTA.12,14-PGD2 is 10-fold more potent...

An aminoglycoside antibiotic derived from kanamycin A.

A selective and irreversible inhibitor of NF-κB activation that blocks TNF-α-induced phosphorylation of IκB-α without affecting constitutive IκB-α phosphorylation; inhibits the TNFα-induced surface expression of adhesion molecules ICAM-1, VCAM-1, and...

A competitive inhibitor of CBX7 chromodomain binding to H3K27me3 (Ki = 43 µM); derepresses transcription of the polycomb repressive complex target gene p16/CDKN2A in prostate cancer cells at 250 µM.

Antigen: hamster brain SAF Host: mouse, clone SAF 61 Isotype: IgG Application(s): EIA and FC

A specific inhibitor of PI3K activity and a widely used inhibitor of the autophagy; at 5 mM, inhibits protein degradation in rat hepatocytes by 65% and blocks class I, II, and III PI3Ks, including some downstream targets.

A competitive GABAA receptor antagonist that at 100 μM blocks spontaneously opening chloride channels in the outside-out patches from the cultured cortical neurons; reversibly blocks GABAA receptors on horizontal cells in the mouse retina (IC50 = 1.7 μM); mimics the action of epilepsy and thus...

Antigen: protein kinase treated and non-denaturated SAF from Syrian Hamster Host: mouse, clone Sha31 Isotype: IgG1 Application(s): EIA and WB