Cayman Chemical

A dual inhibitor of mPGES-1 (IC₅₀ = 3.9 μM ) and 5-LO (IC₅₀ = 4.1 μM); blocks PGE2 and LT synthesis in cell free and intact cell assays, and also in an animal model of inflammation.

TMB is an aromatic amine that undergoes oxidation by the higher oxidation states of heme peroxidases (compounds I and II) thereby serving as a reducing co-substrate. One electron oxidation of TMB results in a radical cation that forms a charge-transfer complex with the unoxidized compound. This...

9(S)-HpOTrE is a monohydroperoxy PUFA produced by the action of 5-LO on α-linolenic acid. It can be further metabolized to colnelenic acid by a divinyl ether synthase activity found in garlic and potato microsomal fractions. 9(S)-HpOTrE also serves as a substrate for further oxidation by both...

An enantiomer of atorvastatin that has little or no inhibitory activity against HMG-CoA reductase.

A selective, reversible inhibitor of MAO-B (Ki = 0.091 μM) over MAO-A (Ki = 9.06 μM); may ameliorate depression, Parkinson’s disease, Alzheimer’s disease, Huntington’s disease, and stroke.

A SRC-3 inhibitor that induces death in various breast cancer cells (IC₅₀s = 3-20 nM) without affecting normal cell viability; inhibits primary tumor growth and reduces SRC-3 protein levels in an MDA-MB-468 breast cancer mouse model.

A carotenoid that occurs naturally in certain algae; significantly reduces abdominal white adipose tissue (WAT) in mice and rats when included in their diet; increases the amount of UCP1 protein in WAT; decreases blood glucose and plasma insulin levels in diabetic mice.

An internal standard for the quantification of PEA by GC- or LC-MS.

Retards the formation of mature amyloid β42 fibrils in a cell-based assay; enhances poly(I:C)-induced IFN-β expression, decreases NF-κB activation, and amplifies the suppression of vesicular stomatitis virus replication by poly(I:C) in HEK293 cells expressing TLR3.

CAY10491 is a synthetic intermediate useful for pharmaceutical synthesis.

A selective ERK5 inhibitor (Kd = 80 nM) that blocks ERK5 autophosphorylation, ERK5-mediated phosphorylation of PML, and PML-dependent activation of p21; suppresses tumor cell proliferation in vitro and tumor growth and angiogenesis in vivo.

ETYA is a nonspecific inhibitor of cyclooxygenases and lipoxygenases. ETYA inhibits human platelet 12-LO and COX-1 with IC₅₀ values of 4 µM and 8 µM, respectively. ETYA is a PPAR ligand which activates PPARα and PPARγ chimeras at concentrations of 10 µM.

15-LO product of linolenic acid; detected in cell membranes and as the cholesteryl ester associated with atherosclerotic lesions.

Non-selective, competitive antagonist of the muscarinic acetylcholine receptor types M1, M2, M3, M4, and M5 (pKBs range from 8.9-9.8); increases firing of the sinoatrial node and conduction through the atrioventricular node of the heart, opposes the actions of the vagus nerve, blocks acetylcholine...

Inhibits maize HDACs: HD2, HD-1B, and HD-1A (IC50s = 7.5-16 nM) and reduces TNFα, IL-1α, and IL-1β production (IC50s = 10-22 nM); inhibits activity of cells expressing JAK2V617F (IC50s = 1-10 nM), which are implicated in the pathophysiology of many myeloproliferative diseases.

Eicosatrienoic Acid (20:3ω-3) is a rare PUFA of the ω-3 series. In normal humans, it represents less than 0.25% of serum phospholipid fatty acids. However, it is one of the most active essential fatty acids when assayed for the inhibition of fatty acid elongation/desaturation reactions...

Cyclooxygenase (COX, also called Prostaglandin H Synthase or PGHS) is a bifunctional enzyme that converts arachidonic acid to a hydroperoxy endoperoxide (PGG₂) and reduces the endoperoxide to the corresponding alcohol (PGH₂), the precursor of prostaglandins, thromboxanes, and...

Antigen: human eNOS amino acids 1186-1203 Host: rabbit Cross Reactivity: (+) bovine and human eNOS; (−) iNOS and nNOS Application(s): IP and WB eNOS catalyzes the formation of NO from L-arginine in many cell types including vascular endothelium, bronchiolar epithelium, cardiac myocytes,...

PGF2α 1,9-lactone is a lipid-soluble internal ester of PGF2α. It is resistant to hydrolysis by human plasma esterases even after incubation for 20 hours under physiological conditions. PGF2α 1,9-lactone exhibits little antifertility and vasoactivity compared to PGF2α.

A carcinogenic aryl hydrocarbon receptor agonist produced by the incomplete combustion of organic matter and found primarily in gasoline exhaust and tobacco smoke.

(±)8-HEPE is produced by non-enzymatic oxidation of EPA. It contains equal amounts of 8(S)-HEPE and 8(R)-HEPE. The ability of (±)8-HEPE to induce hatching of E. modestus and B. balanoides eggs is probably due to the presence of the 8(R) isomer within the racemic mixture.

INDIGO’s panel of RAR reporter assays utilizes non-human mammalian cells engineered to individually express human retinoic acid receptors, RARα (NR1B1), RARβ (NR1B2), or RARγ (NR1B3). INDIGO’s RAR reporter cells include the luciferase reporter gene functionally linked to...

An internal standard for the quantification of trans-resveratrol by GC- or LC-MS.

Ricinoleic acid is a naturally occurring 12-hydroxy fatty acid. It constitutes about 90% of the fatty acids in castor oil. Ricinoleic acid can serve as a substrate for the synthesis of conjugated linoleic acids. It is considered safe and non-toxic as a food constituent in humans, up to a daily...