Cayman Chemical

An alkaline aluminum−sucrose complex that inhibits peptic hydrolysis and raises gastric pH, protecting esophageal epithelium against acid injury; inhibits thrombin activity (IC₅₀ = 4.5 µM) and prevents FGF-2 binding to endothelial cells, inhibiting tumor growth in mouse...

An ATP-competitive inhibitor of mTOR (IC₅₀ = 0.19 nM) that inhibits signaling through both mTORC1 and mTORC2; effective in diverse cancer models, both in vitro and in vivo, blocking mTOR signaling and preventing growth in breast, lung, renal, and glioma cancer cells and tumor xenografts...

A cell imperbeable tyrosine kinase inhibitor that blocks receptor serine and tyrosine phosphorylation; inhibits the insulin-stimulated autophosphorylation of the 95-kDa β-subunit of the insulin receptor (IC₅₀ = 200 µM in vitro).

Antigen: human LCAT protein amino acids 132-143 Host: rabbit Cross Reactivity: (+) human, mouse, porcine, and bovine LCAT Application(s): WB LCAT catalyzes the fatty acid transfer from the sn-2 position of phosphatidylcholine (lecithin) to cholesterol and to a lesser degree to other acceptor...

Exhibits anti-inflammatory and immunomodulatory effects by inhibiting lipid mediator and cytokine release from inflammatory cells and interfering with PDGF- and TGF-β1-induced proliferation and migration of vascular medial smooth muscle cells; inhibits PGD2 (IC₅₀ = 0.1 mM), PGE2...

A cytidine analog that inhibits the reverse transcriptases of HIV1 (IC₅₀ = 45 nM), HIV2, and hepatitis B.

Arachidonic acid ethyl ester is a more lipophilic form of arachidonic acid that can be incorporated into dietary regimens or fed to cultured cells as a source of exogenous arachidonate. It is one of the fatty acid ethyl esters that increase cytosolic Ca2+ concentration leading to pancreatic acinar...

A selective inhibitor of PRMT4 (IC₅₀ = 34 nM) and PRMT6 (IC₅₀ = 43 nM); reduces H3R2me2a in HEK293 cells (IC₅₀ = 0.97 µM) and also, unexpectedly, to reduce H4R3me2a in HEK293 cells.

The A1, A2A, A2B, and A3 adenosine receptors (ARs) are ubiquitous G protein-coupled receptors. The four AR subtypes have been implicated in several areas of therapeutic interest such as stroke and other ischemic conditions, as well as inflammation, neurodegenerative diseases, diabetes, and sleep...

A neutral RARα-selective antagonist (Ki = 2.5 nM); antagonizes agonist-induced coactivator recruitment and moderately decreases SMRT binding to RAR but does not significantly affect nuclear receptor corepressor binding.

8-iso PGA1 is an isoprostane and a member in a large family of prostanoids of non-cyclooxygenase origin. It occurs as a common minor impurity in most commercial preparations of PGE1. The biological activity of 8-iso PGA1 has not been studied in depth or reported in the literature.

A bile salt formed in the liver by conjugation of chenodeoxycholate with glycine that acts as a biosurfactant to solubilize lipids for absorption.

A nonthiazide diuretic that inhibits the sodium/chloride cotransporter in the distal convoluted tubule of the kidney; also effectively inhibits the activity of most platelet carbonic anhydrase isozymes (IC₅₀s = 2.8 nM - 11 µM).

Antigen: human erythrocyte TXB2 11-dehydrogenase Host: rabbit Cross Reactivity: (+) human, porcine, and ovine TXB2 11-dehydrogenase Application(s): WB TXB2 11-dehydrogenase catalyzes the conversion of TXB2 to 11-dehydro TXB2.

A potent and selective agonist of GPR120 with pEC₅₀ values of 7.36 and 7.77 for human and mouse GPR120, respectively.

A fluorescent substrate for the 20S proteasome, other chymotrypsin-like proteases, and calpains (excitation max: 360 nm; emission max: 460 nm).

(±)10-HDHA is an autoxidation product of DHA in vitro. It is also produced from incubations of DHA in rat liver, brain, and intestinal microsomes. (±)10-HDHA is a potential marker of oxidative stress in brain and retina where DHA is an abundant PUFA.

Antigen: human AIF amino acids 151-180 Host: rabbit Cross Reactivity: (+) human, rat, and mouse AIF; other species not tested Application(s): WB AIF is a highly conserved mitochondrial protein with roles in redox-biochemistry and apoptosis.

A fluorescently-labeled deoxyglucose analog that is used primarily to directly monitor glucose uptake by living cells and tissues; also used as a topical contrast reagent for the detection of neoplasia.

Antigen: human CysLT1 receptor C-terminal amino acids 318-337 Host: rabbit Cross Reactivity: (+) human and mouse CysLT1 receptor Application(s): FC The CysLT1 receptor binds LTD4, LTC4, and LTE4, playing a major role in

Formed by the cleavage of the sialic acid residue from ganglioside GM1 by neuraminidase; a component of lipid rafts; serves as a glycolipid receptor for bacterial host response signaling.

Slow isomerization of the C-11 double bond of LTE4 leads to the formation of 11-trans LTE4. 11-trans LTE4 is equipotent to LTE4 in contracting guinea pig ileum.

Molecular Formula: C₁₉H₁₆N₂O₂S₂ Formula Weight: 368.5

Primary plasma metabolite of PGD2; levels increase nearly 3-fold upon allergan-induced bronchoconstriction in asthmatics.