Cayman Chemical

9(R)-HODE is one of several monohydroxylated products of linoleic acid. All known mammalian lipoxygenases appear to catalyze the oxygenation of arachidonic and linoleic acid to give products having strictly the (S) configuration at the site of oxygen insertion. However, both human umbilical vein...

A potent inhibitor of DNA topoisomerase I that induces cytoxicity and DNA damage in human HT-29 colon adenocarcinoma cells (IC₅₀s = 33 nM and 0.28 μM, respectively; demonstrates a broad spectrum of antitumor activity against a variety of other tumors including ovarian cancer, cervical...

An unusual PUFA generated during the synthesis of docosahexaenoic acid-d5.

A control compound for AP39.

A naturally occurring diterpene that directly activates adenylyl cyclase to raise levels of cAMP in a wide variety of cell types; binds to type 1 adenylyl cyclase membranes with an IC50 value of 41 nM and demonstrates an EC50 value of 0.5 μM in an activation assay.

A quinone derivative that inhibits red blood cell PLA2 with a Ki value of 130 µM.

A homolog of LOEA, characterized by the addition of an (S)-α-methyl group at the methylene carbon adjacent to the amide nitrogen.

A widely used, nonspecific CYP450 inhibitor that potentiates the effects of many different different drugs by inhibiting their metabolism (IC₅₀ values in the μM range when tested using human liver microsomes); also acts as a noncompetitive inhibitor of acetylcholine nicotinic...

A stable analog of LTC4 that does not readily metabolize to LTD4 and LTE4 at the expense of marginally reduced biological activity.

A stimulator of sGC, increasing the activity of recombinant sGC dose-dependently, from 0.1 nM to 100 μM, up to 92-fold; in vitro, relaxes vessels and inhibits platelet aggregation at nM concentrations; in vivo, decreases blood pressure dose-dependently, prolongs bleeding time, and reduces...

A synthetic intermediate useful for pharmaceutical synthesis.

A selective and irreversible inhibitor of the gastric H+/K+ ATPase pump (IC₅₀ = 1.1 μM).

A typical antipsychotic that acts as an antagonist at dopamine D2 receptors (Ki = 0.38 nM) and an inverse agonist at serotonin 5-HT2A receptors (Ki = 7 nM).

An inactive analog of PD 150606.

A cuticular pheromone in female fruit flies that stimulates male courtship behavior; biosynthesis appears to be mediated by an elongase with female-biased expression.

A selective p38α MAPK inhibitor (IC₅₀ = 26 nM in a cell-free assay); demonstrates anti-inflammatory activity in chronic disease models.

Source: Recombinant GST-tagged protein expressed in E. coli Mr: 71.2 kDa The isolated individual or tandem bromodomains of BRD2 have been shown to bind acetylated histone tails, serving to couple histone acetylation marks to the transcriptional regulation of target promoters.

D-erythro-Sphinganine is a precursor of ceramide and sphingosine as well as a substrate of sphingosine kinases, which generate sphinganine-1-phosphate. Sphinganine levels increase significantly in response to certain mycotoxins, including fumonisins, as well as in some cancers. Sphinganine can block...

An inhibitor of the eIF4F translation initiation complex that inhibits cap-dependent translation with an IC₅₀ value of ~4 μM; reverses tumor chemoresistance in a mouse model of lymphoma by sensitizing cells to the proapoptotic action of DNA damage.

PGB1 is a non-enzymatic dehydration product of PGE1 resulting from treatment with strong base. Oligomers of PGB1 are known to exhibit antioxidant and ionophoric activity.

A lipophilic analog of 16-phenoxy tetranor PGF2α.

A metabolite of tryptophan that is formed by the alcohol dehydrogenase-catalyzed reduction of the serotonin intermediate, 5-hydroxyindoleacetaldehyde; used as a biomarker for recent alcohol consumption.

A saturated fatty acid found in a gram-negative bacteria, L. arabinosus, in protozoa, and in the seed oil of B. coccineus whose cyclopropane ring structure may regulate cell membrane fluidity.

A natural marine product originally isolated from the red marine alga D. simplex that is a potent CNS stimulant; developed as the prototype neuroexcitatory amino acid for the induction of seizures in experimental animals, at a typical dose of 10-30 mg/kg in mice; neuroexcitotoxic and epileptogenic,...