Cayman Chemical

An orally active PHD2 inhibitor (IC₅₀ = 3.9 µM); stabilizes HIF-α and reversibly stimulate erythropoietin secretion at 100 µM in vitro; increases hematocrit, red blood cell count, and hemoglobin levels at 50 mg/kg in mice.

Donepezil-d₄ (hydrochloride) (Item No. 18251) is intended for use as an internal standard for the quantification of donepezil (Item No. 13245) by GC- or LC-MS. Donepezil is a reversible acetylcholinesterase inhibitor (IC₅₀ = 23 nM) that readily crosses the blood-brain barrier...

A cysteine derivative that interferes with the increase in goblet cell number, expression of the mucin MUC5AC, and subsequent mucin secretion, in airways agonized with tobacco smoke, isoproterenol, lipopolysaccharide, TNF-α, or oxidants.

An activator of the HIF signaling pathway, as demonstrated by HRE reporter assay (EC₅₀ = 1.2 µM), HIF-1α nuclear translocation assay (EC₅₀ = 1.3 µM), and increased VEGF expression (EC₅₀ = 1.6 µM); activity is blocked by excess iron, suggesting...

A brain-penetrant, selective inhibitor of ABHD6 (IC₅₀ = 0.43 µM) that has been used to decrease seizure incidence in a genetic mouse model of juvenile Huntington’s disease as well as in chemically-induced epilepsy models.

Antigen: phosphopeptide corresponding to amino acid residues surrounding the phospho-Ser133 of rat CREB Host: rabbit Cross-reactivity: (+) rat CREB Application: WB CREB is one of the best characterized stimulus-induced transcription factors. This transcription factor is a component of intracellular...

A minor metabolite of the oligomycin complex that is active against Gram-positive bacteria and demonstrates strong antitumor activity against HeLa cells (IC₅₀ = 14 ng/ml).

A cell-permeable derivative of the D-isomer of 2-HG; used to examine the contribution of D-2HG to the oxidative mitochondrial processes of IDH1-mutated cancer cells.

An non-nucleoside reverse transcriptase inhibitor that prevents RNA plus-strand initiation (IC₅₀ = 17 nM); also inhibits the late stages of HIV-1 replication by interfering with HIV-1 Gag-Pol polyprotein processing.

A metabolically stable analog of PGF2α and potent FP receptor agonist (Ki = 1.1 nM at the rat FP receptor).

An isoprostane produced by the non-enzymatic peroxidation of arachidonic acid in membrane phospholipids and the most frequently studied member of the isoprostane family.

Horseradish Peroxidase conjugated to Mouse Anti-6Histidine Antibody: Mouse monoclonal anti-6x histidine IgG, clone AD1.1.10 Enzyme: Horseradish Peroxidase Uses: Western blot detection. Recommended dilution of 1:500-1:10,000. Starting dilution: 1:2,000.

A diterpene acid isolated from the bark of P. kaempferi, a traditional Chinese medicinal plant; has anti-fungal activities and diverse effects that are relevant to cancer therapy.

Altiratinib is a multiple kinase inhibitor, blocking Met, Tie2, VEGF2, TrkA, TrkB, and TrkC with IC₅₀ values of 2.7, 8.0, 9.2, 0.85, 4.6, and 0.83 nM, respectively. It also inhibits several mutant Met isoforms at nanomolar concentrations. Altiratinib inhibits the proliferation of several...

5(S)-HETrE is produced by the action of 5-LO when mead acid is the substrate. There are no literature reports of the biological activity or further metabolic fate of 5(S)-HETrE.

An inhibitor of β-glucuronidase (IC₅₀ = 45 µM for the human enzyme).

A NS3/4A protease inhibitor (Ki = 14 nM) that prevents HCV viral replication; inhibits the NS3/4A protease in an in vitro HCV replicon system (EC₅₀ = 200 nM) and blocks the activity of recombinant HCV genotype 1a and 1b NS3/4A protease enzymes in vitro (Kis = 14 nM for each subtype).

A cell-permeable, fluorescent probe for DNA that is useful as a marker of nuclei for cell cycle studies in combination with BrdU and to distinguish nuclear morphology in apoptotic cells.

A synthetic agonist for GPR84 (EC₅₀ = 512 nM); promotes chemotaxis in human neutrophils (EC₅₀ = 318 nM) and amplifies TNF-α production by LPS-treated U937 macrophages; drives the recruitment of leukocytes and raises serum levels of CXCL1 (GRO-α) in vivo.

A sulfur-containing analog of miltefosine.

An analog of (±)14(15)-EpEDE with greater lipid solubility than the free base.

A monohydroperoxy PUFA produced by the action of 15-LO on α-linolenic acid.

Antigen: bovine lung PGIS Host: mouse, clone isn-1 Cross Reactivity: (+) bovine, mouse, rat, ovine, guinea pig, and rabbit PGIS Isotype: IgG1 Application(s): IHC and IP; WB not recommended PGIS catalyzes the conversion of PGH2 to PGI2 (prostacyclin).

Wy 14643 is a PPAR activator. Although this compound is primarily an activator of PPARα, it activates PPARγ as well. Activation of PPAR.delta. by Wy 14643 is also observed, but this finding is rare. The potency of Wy 14643 as an activator of PPARα is species dependent, with...