Cayman Chemical

A potent and specific inhibitor of NF-kB that exhibits antimitogenic, anticarcinogenic, antiinflammatory, and immunomodulatory properties.

A first-generation antihistamine that potently antagonizes the histamine H1 receptor (pKi = 9.42); also antagonizes serotonin and muscarinic receptors at nanomolar concentrations.

A synthetic substrate of serine proteases, including thrombin, trypsin, chymotrypsin, and kallikreins; also binds to and inhibits anaphase-promoting complex, a ubiquitin ligase, in Xenopus egg extract.

An inhibitor of microtubule assembly.

Sodium Phosphate Stock Solution (500 mM, pH 7.0) contains filtered sodium phosphate (500 mM, pH 7.0). It is ready to use as supplied.

Antigen: peptide from N-terminal region of the α1-subunit of the rat glycine receptor Host: rabbit Cross Reactivity: (+) human, mouse, and rat glycine receptor Application(s): IHC (frozen sections) and WB Glycine is an important inhibitory neurotransmitter whose binding to its receptor...

Antigen: human lipocalin-type PGD synthase amino acids 30-41 Host: rabbit Cross-Reactivity: (+) human and mouse L-PGD synthase; (−) H-PGD synthase; other species not tested Application(s): WB; other applications not tested

Antigen: CRTH2/DP2 protein amino acids 378-395 Host: rabbit Cross Reactivity: (+) human, mouse, and rat DP2 receptor Application(s): ICC and WB

Cayman’s PC Assay provides a specific, sensitive, and convenient method for quantifying PC in plasma or serum. In this assay, PC-Specific PLD hydrolyzes PC to choline and phosphatidic acid. The newly formed choline is then used to generate hydrogen peroxide in a reaction catalyzed by choline...

An activator of sGC that binds to a regulatory site, resulting in activation in an NO-independent manner (Kd = 3.2 nM); reduces hypertension, limits cardiomyocyte hypertrophy, protects against ischemia/reperfusion injury, and reduces morbidity and mortality in response to endotoxic shock.

A third generation EGFR tyrosine kinase inhibitor that inhibits both EGFR activating and T790M resistance mutations, while sparing wild-type EGFR.

1400W is a potent, selective inhibitor of iNOS. Using purified human iNOS, nNOS, and eNOS, 1400W exhibits Ki values of 7 nM, 2 µM, and 50 µM, respectively. In rat aortic rings it is at least 1,000-fold more potent against iNOS compared to eNOS. In mice bearing a murine mammary carcinoma,...

A potent inhibitor of PI3K isoforms α, δ, and γ (IC₅₀s = 0.28, 0.12, and 0.97 nM, respectively) that is 31 times less potent at PI3Kβ; has increased potency in cancer cell lines harboring PIK3CA-activating alterations, and is effective in vivo.

Dimethylallyl pyrophosphate and isopentyl pyrophosphate undergo condensation to yield geranyl pyrophosphate, which undergoes condensation with a second molecule of isopentyl pyrophosphate to yield farnesyl pyrophosphate. Farnesylation is essential for the function of a number of proteins involved in...

Source: Active recombinant N-terminal His-tagged protein amino acids 190-352, expressed in E. coli Mr: 21.1 kDa SET8 selectively mono-methylates histone H4 at lysine 20, an event proven to have an important role in chromatin structure and transcriptional activation. SET8 is also a novel regulator of...

A selective inhibitor of SHP-2 (IC₅₀ = 2.1 µM; Ki = 0.73 µM); inhibits SHP-2-dependent cellular signaling and tumor cell colony formation.

A certified reference material categorized as a phytocannabinoid; intended for research and forensic applications

DAF-2 diacetate is a sensitive fluorescent indicator for the detection and bioimaging of NO. It is a cell-permeable derivative of DAF-2. Upon entry into the cell, DAF-2 diacetate is transformed into the less cell-permeable DAF-2 by cellular esterases thus preventing loss of signal due to diffusion...

A tetracyclic lantibiotic that preferably targets Gram-positive bacteria, inhibiting the synthesis of peptidoglycan.

An irreversible inhibitor of GBA (IC₅₀ = 9 μM); does not inhibit non-lysosomal glucosylceramidase or cytosolic β-glucosidase.

A monohydroxy PUFA produced by the actions of 5-LO on α-linolenic acid.

A steroid hormone secreted by the adrenal cortex that controls sodium and potassium balance.

Urinary metabolite of leucine that is used as a diagnostic tool in the diagnosis of various acidemias and mitochondrial fatty acid β-oxidation defects.

Cayman’s 8-Isoprostane Affinity Sorbent provides a specific and convenient means for the purification of 8-isoprostane (8-iso PGF2α) from urine and plasma samples. Each vial contains 1 ml of affinity sorbent (mouse anti-8-isoprostane monoclonal antibody covalently bound to Sepharose 4).