Cayman Chemical

An internal standard for the quantification of 8-iso PGE2 by GC- or LC-MS.

A food contaminant produced by Aspergillus that is associated with toxicity and hepatocarcinogenicity in human and animal populations.

A minorCYP450 metabolite of arachidonic acid that potently inhibits proximal tubule ATPase activity.

A synthetic enantiomer of the brain-derived oxysterol 24(S)-OH that activates LXRα and LXRβ nuclear receptors with slightly reduced potency (EC50 = 7 and 4 μM, respectively) compared to the natural isomer (EC50 = 4 and 3 μM, respectively).

A potent activator of KCNQ1 (Kv7.1) channels (EC₅₀ = 260 nM); EC₅₀ > 30 µM for KCNQ2, KCNQ4, and hERG; potentiates both homomultimeric KCNQ1 channels and unsaturated heteromultimeric (KCNQ1/KCNE1) channels in model cardiomyocytes and augments IKs current in cultured...

An analog of adenosine 5'-monophosphate that selectively inhibits NAE (IC₅₀ = 4.7 nM) and disrupts CRL-mediated protein turnover leading to apoptosis in cancer cells by deregulating S-phase DNA synthesis.

A cardiotonic steroid that inhibits theNa+/K+-ATPase transporter (Kds = 42, 45, and 40 nM for the α1, α2, and α3 subunits, respectively); inhibits SRC-1 and SRC-3 at doses as low as 5 nM, promotes the degradation of SRC-3 protein, and inhibits cancer cell growth both in vitro and...

Sodium dodecyl sulfate (SDS) 10% (w/v) stock solution contains 10% sodium dodecyl sulfate. It is ready to use as supplied.

A tyrosine kinase inhibitor best known as an inhibitor of VEGFR2 (FLK1/KDR) and a suppressor of tumor vascularization, preventing the growth of multiple tumor types.

A mixed carbamate reagent for the selective preparation of N-(9-fluorenylmethoxycarbonyl) derivatives of hydroxyamino acids and hydroxyamino acid esters in high yields; used in the synthesis of glycopeptides.

Cloprostenol is a synthetic PGF2α analog and a potent FP receptor agonist. (+)-15-epi Cloprostenol is the 15(S), or 15β-hydroxy enantiomer of (+)-cloprostenol. This epimer is less active by several orders of magnitude as an FP receptor ligand when compared to 15(R)-cloprostenol. However,...

Potently binds menin, blocks the menin-MLL fusion protein interaction (IC50 = 0.45 μM), and induces apoptosis in cells expressing MLL fusion proteins.

(+)-Cloprostenol (sodium salt) is a more water soluble, crystalline form of (+)-cloprostenol.

Antigen: DNMT3a expressed in bacteria The epitope was found to be located near the C-terminus (amino acids 705-908) Host: mouse, clone 64B1446 Isotype: IgG1κ Cross Reactivity: (+) human and mouse DNMT3a Application(s): ChIP, IF/ICC, IHC (paraffin), and WB The DNMT3 family members DNMT3a and...

This solution can be used (without further dilution) as a blocking agent for immunocytochemistry or immunohistochemistry when using a secondary antibody generated in goat.

The primary active component of the heat and pain-eliciting lipid-soluble fraction of the Capsicum pepper and present in natural hot pepper extracts; elicits a sensation of burning pain by activation of TRPV1 on small, non-myelinated polymodal C-type nociceptive nerve fibers and has been widely...

An inhibitor of Group IIA sPLA2 (IC₅₀ = 0.47 µM) that interacts with the active site of the enzyme in a non-covalent manner.

A steroidal saponin that displays cytotoxicity against a range of cancer cells in vitro, including leukemia, colon cancer, and prostate cancer cells (GI50 ≤ 2 µM).

19(R)-hydroxy PGE1 is the major prostaglandin found in the semen of primates, including man. It is an agonist for the EP1 and EP3 receptor subtypes, and exhibits contractile activity on smooth muscle preparations. It has an EC₅₀ of 320 nM for contracting guinea pig ileum, which express...

An internal standard for the quantification of α-linolenoyl ethanolamide by GC- or LC-MS.

An α2-adrenergic receptor agonist (effective concentrations 10-100 nM) with hypotensive effects; competes for imidazoline I2-binding sites in brown adipose tissue (Ki = 97 nM).

Source: Active recombinant enzyme expressed in E. coli MW: 46 kDa Lipocalin-type prostaglandin D synthase (L-PGDS) catalyzes the isomerization of PGH2 to produce PGD2 and acts as a carrier protein for lipid-like molecules (i.e., retinoids and thyroid hormones).

A naturally-occurring flavonol which has antimicrobial, antioxidant, and anti-inflammatory activities; inhibits LPS-induced nitric oxide production in mouse macrophages (IC₅₀ = 40 μM); mimics insulin in stimulating glucose uptake in diabetic rats, but inhibits insulin-stimulated...

A 2R,3R stereoisomer of catechin; a powerful antioxidant; inhibits COX-1 (IC50 = 3.2 μM); at 100 µM, induces apoptosis in human adenocarcinoma PC-9 cells and stimulates the inhibition of TNF-α release from BALB-c/3T3 cells treated with epigallocatechin gallate.