Cayman Chemical

TXB2 is released in substantial quantities from aggregating platelets and metabolized during circulation to 11-dehydro TXB2 and 2,3-dinor TXB2.{1410} In rats and rabbits, 2,3-dinor TXB1 has been identified as another urinary metabolite of TXB2.{12600,12599} However in human urine, only trace amounts...

A fluoroquinolone antibiotic that inhibits DNA topoisomerase inhibitor; broad antimicrobial activity against gram-positive and gram-negative bacteria, such as S. pneumoniae, M. hominis, and anaerobic bacteria, including B. fragilis.

A biologically active form of folic acid that functions, in conjunction with vitamin B12, as a methyl-group donor involved in the conversion of homocysteine to methionine.

An enterotoxin that inactivates host Rho family GTPases by glucosylation, altering cytoskeletal structure, cell division, and cell-cell adhesion.

A selective nonphosphoinositide inhibitor that specifically disrupts PIP3/Akt PH domain binding (IC50 = 31 μM); suppresses PI3K-PDK1-Akt-dependent phosphorylation, which reduces cell viability and induces apoptosis in PTEN-deficient U87MG glioblastoma cells (IC50 = 37 μM).

A potent and selective inhibitor of reticulocyte 15-LO-1.

A selective, cell permeable inhibitor of the IκB kinases IKKα and IKKβ (IC₅₀s = 4 and 0.3 µM); inhibits signaling through NF-κB both in cells and in vivo, showing excellent pharmacokinetics in mice.

A gastroprotective histamine H2 receptor antagonist (pKi = 7.1) that decreases gastric acid secretion and inhibits intracellular cAMP production (IC₅₀ = 1 µM).

An internal standard for the quantification of tetranor PGEM by GC- or LC-MS.

A cell permeable, selective inhibitor of the EGFR kinase (IC₅₀s = 21, 63, and 4 nM for EGFR and the L858R and L861Q EGFR mutants, respectively).

A hydrophobic derivative of the class I and class II HDAC inhibitor SAHA that demonstrates >60% inhibition of HDAC1 and HDAC6 activity in a deacetylase activity assay; inhibits proliferation of SK-BR-3 breast-derived, HT29 colon-derived, and U937 leukemia cell lines with EC50 values of 1.1, 0.95,...

An orally available inverse agonist of PPARβ/δ (IC₅₀ = 27 nM), down-regulating transcription of ANGPTL4 in mouse myoblasts (IC₅₀ = 9.5 nM).

An inactive derivative of KN-93, the selective inhibitor of CaMKII; ineffective at inhibiting CaMKII or arresting cell growth of NIH 3T3 fibroblasts at concentrations up to 25 μM.

The renin fluorogenic substrate consists of the normal peptide substrate for renin which has been linked to the fluorophore EDANS at one end and to a non-fluorescent quenching molecule (Dabcyl) at the other. After cleavage by renin, the product (peptide-EDANS) is brightly fluorescent and can be...

(±)5-HETE lactone is a cyclic ester formed by acid-catalyzed nucleophilic addition of the C-5 hydroxyl to the C-1 carboxyl of (±)5-HETE. (±)5-HETE lactone is an inhibitor of 5-LO from rat basophilic leukemia cells with an IC₅₀ of 27 µM. The lactone is several...

D-myo-Inositol-3,4,5-triphosphate (Ins(3,4,5)-P3) is a structural analog of Ins(1,4,5)-P3 and a member of the inositol phosphate (InsP) cell signaling family of molecules. D-myo Ins(3,4,5)-P3 is 200-fold less potent than D-myo Ins(1,4,5)-P3 at initiating Ca++ release when injected into Xenopus...

A partial agonist for PPARγ (Ki = 160 nM) which induces adipogenesis significantly less than the full activator rosiglitazone; reverses high fat diet-mediated impairments in insulin signaling; does not induce weight gain, hyperphagia, or edema; does not activate PPARα,...

An antagonist of Bcl-2 family members containing four Bcl-2 homology domains, including Bcl-2, Bcl-W, Bcl-xL, and Mcl-1 (Kd ~500 nM); prevents interaction of these pro-survival proteins with Bax or Bak, inducing apoptosis; also induces autophagy in mouse embryo fibroblasts and in HeLa cell.

A toxin that selectively eliminates pancreatic β-cells in mice, rats, and certain other animals, and is used to model type 1 diabetes in humans.

A cell-permeable, reversible inhibitor of Syk (Ki = 7.5 nM; IC50 = 10 nM); inhibits degranulation (IC50 = 5-46 nM) and blocks cytokine release from mast cells; also sensitizes MCF-7 breast cancer cells to TRAIL-mediated apoptosis.

An antibiotic that selectively inhibits cellular lipid biosynthesis (IC₅₀ = 0.1 μM) by targeting FabF/B, an enzyme important for the biosynthesis of fatty acids; also inhibits mammalian fatty acid synthase, which reduces liver triglyceride levels and improves insulin sensitivity in a...

Antigen: human PPARδ amino acids 39-54 Host: rabbit Cross Reactivity: (+) human, mouse, ovine, porcine, and rat PPARδ Application(s): ICC, IHC, and WB

An inhibitor of FMN riboswitch-mediated expression of ribB, a gene responsible for the synthesis and transport of riboflavin; depletes cellular levels of riboflavin (IC₅₀ = 0.3 µM) and inhibits E. coli growth (MIC = 2 µg/ml).

Selectively inhibits NOD1-dependent activation of NF-κB and MAPK signaling (IC50 = 0.6 μM) and also inhibits NOD1-induced IL-8 production in MCF-7 cells without affecting viability.