Cayman Chemical

A cell-permeable, non-competitive inhibitor of neutral sphingomyelinases (IC₅₀ = 1 μM), that does not affect acid sphingomyelinase activity; inhibits TNF-α-mediated sphingomyelin hydrolysis (100% inhibition at 20 μM) and TNF-α-induced cell death in MCF-7 cells.

A purified enantiomer of (±)9-HETE resulting from non-enzymatic oxidation of arachidonic acid.

A derivative of NBD modified with a hexanoic acid tail, which provides a reactive carboxylic acid site; used to synthesize a variety of fluorescently-tagged compounds for research purposes.

A reversible, broad-range inhibitor of MMP-1 (IC₅₀ = 24 nM), MMP-3 (IC₅₀ = 18.4 nM), MMP-7 (IC₅₀ = 30 nM), and MMP-9 (IC₅₀ = 2.7 nM).

A natural iridoid glycoside that blocks changes in acid phosphatase activity, phospholipid levels, and lipid peroxide production induced by D-galactosamine in rat liver; also enhances neurite outgrowth in PC12D cells induced by bFGF and 7S NGF when given at 60 μM.

A monohydroperoxy PUFA produced from arachidonic acid by 12-LO.

Formal Name: 4-(4-methyl-1-piperazinyl)-6-phenyl-2-pyrimidinamine CAS Number: 1028327-66-3 Molecular Formula: C₁₅H₁₉N₅

Preparation of nuclear extracts is the first step in examining transcription factor activity. Cayman’s Nuclear Extraction is formulated for the quick and simple isolation of nuclear and cytoplasmic fractions from cultured cells and tissue homogenates that can be used successfully in...

11-deoxy PGF1β is a synthetic analog of PGF1β. In contrast to PGF2α and PGF1α, 11-deoxy PGF1β exhibits vasodepressor and bronchodilator activities in guinea pigs at a dose of 500 µg/kg.

A potent antagonist for the human IP (prostacyclin) receptor that antagonizes the carbaprostacyclin-induced activation of human neuroblastoma adenylate cyclase, blocking cAMP accumulation in a dose-dependent manner; inhibits the binding of tritiated iloprost to rodent neuroblastoma cells (Ki = about...

An adamantine derivative that selectively blocks Ca2+-permeable glutamate receptor channels (IC₅₀ = 10 μM - 0.1 mM).

A naturally occurring plant hormone of the auxin class that stimulates cell elongation and division, promoting plant growth and development.

A pyroglutamylated form of apelin-13, in that the N-terminal glutamine residue is cyclized to pyroglutamic acid; a potent APJ receptor agonist (EC₅₀ = 0.30 nM); the major apelin isoform in the plasma of healthy human subjects.

A synthetic analog of natural PtdIns containing C8:0 fatty acids at the sn-1 and sn-2 positions; contains the same inositol and DAG stereochemistry as the natural compound.

α-ESA is a conjugated PUFA commonly found in plant seed oil. This fatty acid accounts for about 60% of the total fatty acid composition of bitter gourd seed oil and about 70% in tung oil. α-ESA is metabolized and converted to conjugated linoleic acid (9Z,11E-CLA) in rats. It has shown...

A synthetic intermediate useful for pharmaceutical synthesis.

An antitumor antibiotic that inhibits nuclear export and translocation of Rev, a regulatory gene product in the HIV genome.

Lenvatinib is a potent inhibitor of VEGF-R2 and VEGF-R3 kinase activities with IC₅₀ values of 4.0 and 5.2 nM, respectively.. It is slightly less potent against the related receptor kinases VEGF-R1, FGF-R1, PGDFR3β and Kit (IC₅₀ values of 22, 46, 39, and 100 nM,...

PAF C-16 is a naturally occurring phospholipid produced upon stimulation through two distinct pathways known as the “remodeling” and 'de novo' pathways. It is a potent mediator of neutrophil migration, and the production of reactive oxygen species, and IL-6 in human macrophages....

Used as a standard for the analysis of fatty acids, when the fatty acids have been transesterified to methyl esters before analysis.

A 14-carbon cyclopentanone that is structurally related to a variety of plant oxylipins.

A natural alkaloid that acts as a selective and reversible α2-adrenergic receptor antagonist (Ki = 12 nM); also acts as a receptor antagonist at the serotonin 5-HT2B receptor (Ki = 14.3 nM).

Key urinary metabolite of PGD2; represents approximately 1% and 4% of the infused radiolabeled dose in monkeys and humans, respectively.

An antimalarial drug used in the treatment of persistent liver forms of P. vivax or P. ovale infection for its ability to kill late-stage gametocytes and hypnozoites.