Cayman Chemical

Immunogen: synthetic peptide from the N-terminal region of human protein PAF receptor Host: rabbit Species Reactivity: (+) human, mouse, porcine, and rat PAF receptor Application(s): FC, IHC, and WB PAF is a biologically active phospholipid whose biological effects include activation of platelets,...

An inhibitor of mitochondrial F1FO ATP synthase that induces apoptosis in a variety of cell types (average GI50 = 270 nM); exhibits antifungal, antitumor, and nematocidal activities, but has poor solubility in water and other biocompatible solvents.

A selective inhibitor of the β5i (LMP7) subunit of the immunoproteasome (IC₅₀s = 65 and 73 nM for mouse and human, respectively) that demonstrates significantly weaker activity at the β5 subunit of the constitutive proteasome (IC₅₀s = 0.92 and 1.04 µM for mouse...

An inhibitor of fatty acid transport that has been used as an affinity label for certain membrane proteins that bind to fatty acids.

An analytical reference standard categorized as an intermediate in the phytocannabinoid biosynthetic pathway; a precursor in the synthesis of CBGA, ?9-THC, and CBD; intended for research and forensic applications

An inhibitor of the tyrosine kinase domains of VEGFR2, FGFR1, and PDGFRβ (IC₅₀s = 0.02, 0.03, and 0.51 µM, respectively).

A potent, reversible inhibitor of ATM kinase (IC₅₀ = 6.3 nM), blocking the phosphorylation of ATM substrate proteins; sensitizes glioma cells to radiation and inhibits migration and invasion of glioma cells in vitro; produces radiosensitization and increases survival in vivo when...

A selective, reversible inhibitor of V-ATPases in mammalian, plant, or fungal cells.

A potent orally available inhibitor of Syk (Ki = 30 nM); blocks FcεRI-dependent mast cell activation (EC50 = 43 nM) and, at 3 μM, reduces the release of IL-10, -12, and -13 by immune complex-pulsed dendritic cells.

An analog of MAFP, which has been widely studied as an inhibitor of phospholipases, FAAH, and as a CB receptor ligand; pharmacology of the α-linolenyl analog of MAFP has not been completely investigated.

A PKCα and PKCβ1 inhibitor with IC₅₀ values of 2.3 and 6.2 nM, respectively; also inhibits the checkpoint kinases Chk1/2 and abrogates DNA damage-induced cell cycle arrest, leading to cytotoxicity in p53 mutant tumor cells.

A dehydration product of PGD2 formed by the elimination of the C-9 hydroxyl group; inhibits platelet aggregation (IC₅₀ ~ 5-10 nM); has antimitotic and antiproliferative effects on a variety of cultured normal cells and tumor cell lines.

Luteinizing hormone (LH) is a glycoprotein produced by the pituitary gland and consists of two subunits with a total molecular mass of approximately 30 kDa. The α-subunit is identical to the α-subunit of other pituitary hormones, such follicle stimulating hormone (FSH), thyroid...

An inhibitor of human recombinant PDE5 (IC₅₀ = 5.9 µM); used to treat erectile dysfunction and has been shown to have anti-cancer and antioxidant activity; induces differentiation of cardiomyocytes and increases the proliferation and differentiation of cultured human osteoblasts.

A synthetic phosopholipid that can be used for liposome production in order to study the properties of lipid bilayers.

An autoregulative inhibitor of spore germination in the genus Streptomyces at concentrations as low as 200 pM; also inhibits the porcine Na+/K+-activated ATPase (ID50 = 100 µM).

A selective nonpeptide allosteric, inverse agonist of CXCR2 (Kd = 2.51 nM); prevents neutrophil chemotaxis both in vitro and in a rat model of hyperoxia-induced lung injury.

A major milk oligosaccharides that avidly bind several viral strains, including strains of influenza, HIV-1, reovirus, and polyomavirus; used to differentiate and characterize the binding domains of viruses that recognize N-acetylneuraminic acid-capped cell surface receptors; also used as an...

A racemic mixture of the lactone form of the free acid, 8,12-iso- iPF2α-VI; the free acid is the most abundant F2-iP2 regioisomer measured in the urine of rats treated to induce lipid peroxidation; used as a biomarker for oxidative stress.

16-phenoxy PGF2α is a metabolically stable analog of PGF2α. It binds to the FP receptor on ovine luteal cells with much greater affinity (440%) than PGF2α.

CYPMPO is a free radical spin trap with excellent trapping capabilities toward hydroxyl and superoxide radicals in biological and chemical systems. Decay of the superoxide adduct of CYPMPO proceeds in an apparent first order fashion with half-lives of 15 and 51 minutes in a UV-illuminated hydrogen...

A form of FAHFA in which oleic acid is esterified to 13-hydroxy stearic acid.

An analog of trimethoxy resveratrol; inhibits the growth of a variety of human tumor cell lines at concentrations form 0.4 to 2 µg/ml, which is 5-6 times more potent than resveratrol

Linoleic acid is an essential fatty acid and one of the most abundant PUFAs in the western diet. Deficiencies in linoleic acid are linked to defective wound healing, growth retardation, and dermatitis. Linoleic acid is metabolized by 15-LO in both plants and animals to form 9- and 13-HODE.