APIS Assay Technologies

The APIS ESR1 Mutations Kit is a multiplexed qPCR assay for the sensitive and precise detection (≤1% MAF) of mutations within the oestrogen receptor gene from cfDNA or FFPE-extracted gDNA. The ESR1 Mutations Kit is a qualitative test, detecting eleven ESR1 mutations across three hotspot exons:...

The APIS MET Alterations Kit is a unique real-time PCR (RT-qPCR) assay simultaneously detecting both MET exon 14 skipping mutation (METΔex14) and MET gene overexpression, using RNA extracted from FFPE non-small cell lung cancer (NSCLC) tissue or blood plasma (cfRNA). The APIS MET Alterations...

The APIS Breast Cancer Subtyping Kit is a highly reproducible, RT-qPCR-based kit for detecting mRNA expression of standard breast cancer biomarkers (HER2, ER, PR, Ki67) and novel proliferative biomarkers from core-needle biopsy (CNB) or resected formalin-fixed paraffin embedded (FFPE) breast tumour...

The APIS DPYD qPCR Kit is designed for fast and efficient detection of seven DPYD alleles. Each reaction identifies both wildtype (WT) and variant alleles, directly from blood or extracted genomic DNA (gDNA). The kit’s rapid turnaround time, cost-effectiveness, and easy integration into...

The APIS ESR1 qPCR Kit is a highly multiplexed qPCR assay for the sensitive and precise detection (≤0.5% MAF) of mutations within the oestrogen receptor gene from cfDNA or FFPE-extracted gDNA. The ESR1 Mutations Kit is a qualitative test, detecting eleven ESR1 mutations across three hotspot...

The APIS ESR1 dPCR Kit is a digital PCR (dPCR) workflow allowing for reliable detection of mutations within the oestrogen receptor (ESR1) gene. The kit detects eleven ESR1 mutations across three exons: exon 5 (E380Q), exon 7 (S463P) and exon 8 (P535H, L536R, L536Q, L536H, L536P, Y537C, Y537S, Y537N...

The APIS ESR1 Mutations Controls serve as a quality control material and can be used for oestrogen receptor gene (ESR1) mutations assay validations, or alongside the APIS ESR1 Mutations Kit as run validity controls. The product consists of two tubes, a negative and a positive control. The positive...

The APIS PIK3CA Mutations Kit is a real-time qualitative PCR test for the highly sensitive (≤0.5% MAF) detection of the five most prevalent activating mutations in the PIK3CA gene, using a sample of DNA extracted from either formalin-fixed, paraffin-embedded (FFPE) breast tumour tissue or blood...