Caerulein is a gastroregulatory molecule with actions similar to cholecystokinin. Product supplied as a trifluoroacetate salt. Caerulein is used to study cell signaling mediated by NF-kappaB upregulation of proteins such as intercellular adhesion molecule-1(ICAM-1) and inflammation related…

Pokeweed mitogen is extracted from pokeweed roots. This protein has hemagglutinating, leukoagglutinating, and mitogenic properties. PWM is not blood group specific, but has affinity for N-acetyl-β-D-glucosamine oligomers. Reconstitution: Reconstitute with 0.01M sodium phosphate-0.15M sodium…

Actinomycin D is a polypeptide antibiotic first described by Waksman. It is bacteriostatic in nature, especially towards gram negative bacteria, and also has anti-tumor activity. Actinomycin D has a wide-ranging applications ranging from a selection agent in cell culture, use in studies of…

Cell permeable, potent and selective class IIb HDAC6 inhibitor (IC50 =12nM). Displays high selectivity over HDAC1 (IC50=6.8µM). Neuroprotective. Effectively prevents neuronal cell death upon oxidative stress induction by HCA and selectively induces cellular alpha-tubulin hyperacetylation.…

Rapamycin is a member of the macrolide immunosuppressant family and a FRAP inhibitor. Rapamycin is unique in its ability to inhibit lymphokine induced cell proliferation at the G1 and S phase as well as an irreversible cellular arrest at the G1 phase in S. cerevisiae cells. It also exhibits…

Leupeptin is a modified tripeptide reversible protease inhibitor of trypsin-like proteases and some cysteine proteases including endoproteinase Lys-C, kallikrein, papain, thrombin, cathepsin B, cathepsins H and L, trypsin, calpain, trypsin8 and plasmin. Effective concentration is typically 10-100…

Benzoquinone ansamycin antibiotic. Herbicidal compound. Potent, selective, irreversible and cell permeable protein tyrosine kinase inhibitor. Inhibitor of v-Src, Yes, Fps, Ros, Bcr-Abl and ErbB oncogene products. Antitumor compound. Antiangiogenic. Inhibits NF-kappaB activation and phosphorylation…

Product is goat affinity purified antibody to human IgA (α-chain) and buffer salts. IgA antibody is a secretory antibody and is present abundantly in mucous linings of gastrointestinal, respiratory and genitourinary tracts, tears and saliva. Thus, secretory IgA contributes to the humoral…

A modified tripeptide reversible protease inhibitor of trypsin-like proteases and some cysteine proteases including endoproteinase Lys-C, kallikrein, papain, thrombin, cathepsin B, cathepsins H and L, trypsin, calpain, trypsin and plasmin. Little to no inhibition is seen against pepsin, cathepsins…

Avidin is a basic glycoprotein consisting of four essentially identical subunits. The combined molecular weight of the subunits is about 66,000. Each subunit is a single polypeptide chain containing 128 amino acid residues with alanine at the N-terminal, glutamic acid at the C-terminal, and a…

Fibronectins are adhesive glycoproteins and are found both as cell surface proteins and in plasma. Human fibronectin (HFN) is suitable for use as an attachment factor in the propagation of cells in vitro when used to coat cell culture surfaces, including plasticware, glassware, and…

Muscimol is a structural analog of γ-amino butyric acid. It functions as a GABA-agonist: a positive analog of the natural transmitter, which can activate GABA receptors in the brain. Muscimol is an isoxazole derivative occurring naturally in the mushroom Amanita muscaria. Muscimol has been…

Product Description Phytotoxin. Antibiotic. Antiviral and antineoplastic agent. Antileishmanial agent. Reversible inhibitor of eukaryotic nuclear DNA replication. Useful for cell synchronization. Blocks the cell cycle at G1/S phase. Prolongs the half life of DNA methyltransferase. DNA…

Macrolide antibiotic. Specific vacuolar-type H+-ATPase inhibitor. Distinguishes among different types of ATPases. Inhibitor of endosomal, lysosomal and vacuolar acidification. Prevents lysosomal Ca2+ uptake. Inhibitor of autophagic degradation by rising pH and thus inactivating the lysosomal acid…

Ionomycin is an ionophore produced by the bacterium Streptomyces conglobatus. It is a polyether ionic antibiotic that exhibits an affinity for Ca2+. It is used in research to raise the intracellular level of calcium (Ca2+) and as a research tool to understand Ca2+ transport across biological…

Acetoacetyl coenzyme A (Acetoacetyl-CoA) may be used as a substrate for a number of enzymes including; acetoacetyl-CoA thiolase (EC 2.3.1) which produces acetyl-CoA in reverse condensation reaction and (3-Hydroxy-3-methylglutaryl coenzyme A (CoA) synthase (HMGCS)) which produces…

Pepstatin A is a reversible inhibitor of aspartic proteases, Inhibitor for pepsin, renin, cathepsin D, cathepsin G, and other acid proteases. It does not inhibit thiol proteases, neutral proteases or serine proteases. Pepstatin forms a 1:1 complex with acid proteases (carboxyl proteases). …

FITC-Val-Ala-Asp(OMe)-FMK is an inhibitor for General Caspases.

Methotrexate is a cell cycle arresting agent with varying effects. Methotrexate has been reported to arrest the cell cycle in late G1/S thus leading to the inhibition of the synthesis of DNA, RNA, thymidylates, and proteins. The main mechanism of action is reported to involve the inhibition of…

Product Description Most commonly-used phorbol ester. Binds to and activates protein kinase C (PKC) at nM concentrations. Induces cell growth arrest through a variety of pathways including the mitogen-activated protein kinases (MAPKs), p38 and c-Jun N-terminal kinase (JNK) pathways mediated by…

Lectins are proteins or glycoproteins of non-immune origin that agglutinate cells and/or precipitate complex carbohydrates. Lectins are capable of binding glycoproteins even in presence of various detergents. The agglutination activity of these highly specific carbohydrate-binding molecules is…

Protein A is a recombinant Fc-binding protein from Staphylococcus aureus, Cowan strain-1 gene. The product is a carboxy truncated material containing 301 amino acid residues. The non-binding regions have been removed to minimize potenial steric interference. Protein A may be conjugated with…

This is a purified product supplied in 0.05% sodium azide. The typical working dilution is 1:50-1:150.

Isodesmosine is prepared according to the method of Starcher, et al. from hdrolyzed bovine neck ligament by solvent extraction and chromatography on Dowex 50.

Cell permeable fungal toxin that disrupts contractile microfilaments by inhibiting actin polymerization. This, in turn, induces DNA fragmentation, inhibits cell division, and disrupts many cell processes. Inhibits glucose transport. One of a group of fungal metabolites that interfere with a wide…

The FMK peptides are potent, cell permeable, irreversible inhibitors. It is useful for in vitro and in vivo applications. BOC-ASP(OMe)-FMK is an inhibitor for general Caspases. The novel Boc-D(OMe)-FMK inhibitor synthesized using proprietary technology is cell permeable and irreversibly binds…

Cell permeable, potent and selective class IIb HDAC6 inhibitor (IC50 =114nM). Displays selectivity over other HDACs (IC50=1-8µM). Neuroprotective and anti-neuroinflammatory agent. Reduced neuronal degeneration after traumatic brain injury (TBI). Shown to increase histone H3 acetylation. HDAC6…

E-64 is an inhibitor for thiol protease, papain, actinidin, ananain, bromelain, calpain and cathepsin B. It is an irreversible cysteine protease inhibitor that has no action on cysteine residues in other plants and does not react with low molecular weight thiols such as 2-mercaptoethanol. Specific…

Product is human fibronectin and buffer salts. Purified Human Fibronectin is used as immunochemical standard and also as a cell attachment and proliferation assays on human endothelial cells, human keratinocytes and human dermal fibroblasts. Human fibronectin (HFN) is suitable for use as an…

Potent, cell permeable adenylyl cyclase activator. Increases intracellular cAMP levels. Widely used tool to investigate cAMP as a second messenger. Inotropic and antihypertensive. Smooth muscle relaxant/vasodilator. Glucose transporter inhibitor. Platelet aggregation inhibitor. Stimulates lipolysis…

Cell permeable, potent and selective class IIb HDAC6 inhibitor (IC50 =11nM). Displays high selectivity over HDAC1 (IC50=1.5µM). Neuroprotective. Effectively prevents neuronal cell death upon oxidative stress induction by HCA and selectively induces cellular alpha-tubulin hyperacetylation.…

Antipain hydrochloride is a peptidyl arginine aldehyde protease inhibitor produced by actinomycetes. (Merkmillipore) Antipain acts by forming a hemiacetal adduct between the aldehyde group of the inhibitor and the active proteinase. Antipain inhibits trypsin, papain, and catherpsins A and B (a…