Protein A is a highly stable surface receptor which is capable of binding the Fc portion of immunoglobulins, especially IgGs, from a large number of species. Each protein A molecule can bind 2 molecules of IgG, allowing the formation of a precipitate. Protein A may be coupled to a wide variety…

Aprotinin is a protein consisting of 58 amino acids, arranged in a single polypeptide chain that is crosslinked by three disulfide bridges. Aprotinin is found in bovine lymph nodes, lung, parotid gland, spleen, liver, pancreas, seminal vesicles, thyroid gland, kidney, mucous membranes of the…

Lyophilized from 0.02M Ammonium Bicarbonate (may contain traces of buffer salt). β-2-Microglobulin is a cancer and renal biomarker. Excellent for controls or calibrators in enzyme assays. Reconstitution: To reconstitute use a phosphate buffer, pH >7.0, containing 0.15 M NaCl.

Tubulin, Purified from Bovine Brain, 1 mg. Purified bovine brain tubulin protein supplied in liquid form at 10 mg/mL in 80 mM PIPES buffer containing 1 mM EGTA, 1 mM GTP, pH 6.8 and 10% glycerol. It is a heterodimer composed of a- and ß- tubulin of 55 kDa (molecular weight ?110 kDa). Polymerization…

Anti-GFP, Clone 3E6, is a mouse IgG2a monoclonal antibody (mAb) that recognizes the native form of the Green Fluorescent Protein (GFP), GFP variants and GFP-fusion proteins. Mouse, Anti-GFP, Monoclonal Antibody Is used for the detection of GFP and variants in applications where the GFP is in a…

Stachyose Tetrahydrate

PMA activates Ca2+- ATPase and potentiates forskolin-induced cAMP formation. It has been shown to inhibit apoptosis induced by the Fas antigen, but PMA induces apoptosis in HL-60 promyelocytic leukemia cells.

Goat affinity purified F(ab')2 fragments to human IgM (5Fc µ) and buffer salts. The affinity purified F(ab')2 fragment is prepared from the specific goat IgG fraction by limited digestion with pepsin and solid phase absorption. The resulting affinity purified F(ab')2 fragment is dialyzed into 0.02M…

Crocetin is a natural carotenoid dicarboxylic acid that is found in the crocus flower and Gardenia jasminoides. Crocetin was found to inhibit cell cycle progression at the G2-M phase and pancreatic tumor formation in nude mice. It has been shown to improve postshock recovery of cellular…

Citrinin is a fungal metabolite found in moldy rice. Citrinin was used to evaluate toxicity of the mycotoxin citrinin using yeast ORF DNA microarray and Oligo DNA microarray.

Staurosporin is an antibiotic which is isolated from Streptomyces species, possesses inhibitory activity against fungi and yeasts. It is potent inhibitor of phospolipid/Ca2+ dependent and cyclic nucleotide dependent protein kinases, a potent protein kinase inhibitor useful as a tool for studies on…

Tunicamycin is a mixture of Tunicamycins A, B, C and D. It is a nucleoside antibiotic active in vitro against Gram-positive bacteria, yeasts, fungi, and viruses. Tunicamycin has been used to study the effect of N-linked glycosylation of human proton-coupled folate transporter (HsPCFT) in HeLa…

Tubulin, porcine, 99% pure, 1 mg. Tubulin is composed of a heterodimer of two closely related 55 kDa proteins called alpha and beta tubulin.

Anticancer compound. Chemotherapeutic used in patients with cancer and advanced forms of Kaposi's sarcoma. Microtubule assembly stabilizer. Reversibly binds to polymerized tubulin. Anti-mitotic. Mitotic spindle assembly, chromosome segregation and cell division inhibitor. Induces cell cycle…

Protease from Staphylococcus aureus strain V8 is composed of a single polypeptide chain. The Staphylococcus strain V8 protease specifically cleaves peptide bonds on the carboxyl (COOH) terminal side of aspartic and glutamic acid residues. Protease V8 is used for selective cleavage of proteins…

Cell permeable mycotoxin. Actin polymerization inhibitor. Binds to the barbed end of actin, reversibly inhibiting the elongation and shortening of actin filaments. Induces nuclear extrusion. By disrupting actin polymerization, blocks diverse cellular functions, including cell division, migration,…

Cell permeable, potent and selective class IIb HDAC6 inhibitor (IC50 =3nM). Displays high selectivity over all other HDACs (IC50=0.03-20µM). Induces cellular alpha-tubulin, but not histone H3 hyperacetylation in Neuro-2a cells. Promotes mitochondrial transport. Shows improved kinetics and…

Acetyl-CoA is produced via beta-oxidation of fatty acids, via the metabolism of carbohydrates - glucose 6-phosphate to pyruvate to acetyl-CoA and via the catabolism of amino acids. Acetyl-CoA has a number of metabolic opportunities. It is metabolized in the tricarboxylic acid cycle to produce…

Cell permeable, potent and selective class IIb HDAC6 inhibitor (IC50 =5nM). Displays high selectivity over all other HDACs (IC50=0.2-11µM). Induces cellular alpha-tubulin, but not histone H3 hyperacetylation in Neuro-2a cells. Promotes mitochondrial transport. Shows improved kinetics and…

Bestatin is a dipeptide antitumor antibiotic. It shows no inhibition against aminopeptidase A, trypsin, chymotrypsin, elastase, papain, pepsin or themolysin. Activates macrophages and T lymphocytes and also has antitumor properties. It binds to cell surfaces and is an inhibitor for aminopeptidase B…

Fibronectin are adhesive glycoproteins and are found both as cell surface proteins and in plasma. They are large glycoproteins found in cells and extracellular fluids. They are involved in a wide range of biological activities including cell adhesion to extracellular matrices, blood coagulation and…

Prostaglandin E2 is one of the primary cyclooxygenase products of arachidonic acid and one of the most widely investigated prostaglandins. Its activity influences inflammation, fertility and parturition, gastric mucosal integrity, and immune modulation. The effects of PGE2 are transduced by at…

α-Thrombin from Bovine Plasma is highly specific serine protease. Thrombin is the final coagulation protease in regard to hemostasis, promoting both procoagulant and anticoagulant effects. Thrombin is used for site specific cleavage of recombinant fusion proteins containing an accessible…

Natural tomato lycopene is a mixture of isomers, primarily (all-E), but also some (5-Z) and two lesser and unidentified cis isomers, all of which are difficult to resolve by LC. Lycopene is an open chain unsaturated carotenoid that gives tomatoes, guava, rose hip, watermelon and pink grapefruit its…

Streptavidin is a protein produced by the bacterium Streptomyces avidinii. It has four binding sites for biotin, as does avidin. Both have been used extensively as probes in immunochemical systems, conjugated to antibodies, enzymes or fluorochromes. However, avidin is highly basic (pI ~ 10.5),…

Thapsigargin is a cell-permeable sesquiterpene lactone found in the roots of Thapsia garganica. It is a tumor promotor and induces the release of intracellular stored Ca2+ without hydrolysis of inositolphospholipids via inhibition of endoplasmic reticulum Ca2+-ATPase. Thapsigargin may be used…

Potent competitive gamma-aminobutyric acid type A (GABAA) receptor antagonist and glycine receptor agonist. Weak nicotinic acetylcholine receptor agonist. Muscle relaxant. Anti-inflammatory. Has analgesic properties. Shows strong epileptogenic and convulsant activity. Anticancer compound through…

Z-Val-Glu(OMe)-Ile-Asp(OMe)-FMK is a synthetic peptide that irreversibly inhibits activity of VEID-dependent caspases (e.g., caspase-6). The inhibitor is designed as a methyl ester to facilitate cell permeability. Z-Val-Glu(OMe)-Ile-Asp(OMe)-FMK used for both in vitro and in vivo studies. If the…

The novel Z-VAD(OMe)-FMK inhibitor synthesized using proprietary technology is cell permeable and irreversibly binds to activated Caspases to block apoptosis. Apoptosis is a physiological form of cell death, which plays an important role in embryogenesis, cellular homoestasis, tissue atrophy, and…

Angiotensin II is a peptide hormone which plays an important role in the regulation of blood pressure. It stimulates the release of aldosterone from the adrenal gland. It has strong vasoconstrictive effects. Angiotensin II plays an important role in the regulation of blood pressure. It…

Cell permeable, potent and selective class IIb HDAC6 inhibitor (IC50 =9nM). Displays high selectivity over all other HDACs (IC50=0.1-12µM). Induces cellular alpha-tubulin, but not histone H3 hyperacetylation in Neuro-2a cells. Promotes mitochondrial transport. Shows improved kinetics and…

An antineoplastic of Rhodomycin group; Antibiotic; Inhibitor of enzymes and metabolic pathways. A potent anticancer agent that has been shown to be a strong inhibitor of DNA and RNA synthesis. Daunorubicin hydrochloride is used in photostability , antileukemic, and drug metabolism studies. …