The FMK peptides are potent, cell permeable, irreversible inhibitors. It is useful for in vitro and in vivo applications. BOC-ASP(OMe)-FMK is an inhibitor for general Caspases.
The novel Boc-D(OMe)-FMK inhibitor synthesized using proprietary technology is cell permeable and irreversibly binds to activated caspases to block apoptosis.
Apoptosis is a physiological form of cell death, which plays important role in embryogenesis, cellular homoestasis, tisue atrophy, and removal damaged and mutated cells. Caspases, which act as molecular chainsaw are the central components of apoptosis response. Caspases are cysteine proteases that cleave after aspartate residue in their substrates. At least 7 of 14 known mammalian caspases have important role in apoptosis.
Key Applications: Apoptosis
Application Areas: Apoptosis, Cell Viability Analysis, Cell Signalling
Research Areas: Caspase Activation
Product Type: Proteins, Enzymes & Peptides
Protein or Enzyme Type: Activators, Inhibitors & Substrates
Presentation: Oil to white solid
Format: Solid
NOTES: The Carboxyl groups are OMe ester form to enhance cell permeability. If purified enzyme is used, esterase should be added for the hydrolysis of the ester groups.
Solubility: Soluble in DMSO (20 mM).
Storage & Handling: Store at 2 to 8°C