Cayman Chemical

A non-enzymatic adduct formed from 15-deoxy-Δ12,14-PGJ2 and glutathione.

An imidazopyridine derivative that prevents Gli-dependent transcriptional activity (IC₅₀ = 30 nM) by inhibiting alcohol dehydrogenase 7 (IC₅₀ = 210 nM) and depolymerizing microtubules; antiproliferative in a range of cancer cell lines (GI50s = 3-21 nM) and in pancreatic cancer...

A cell-permeable, selective PDE4 inhibitor (IC₅₀ = 2 µM); inhibits the release of cytokines and other inflammatory signals as well as prevents the development of reactive oxygen species.

Inhibits nNOS, iNOS, and eNOS (Ki = 0.3, 3, and 2.5 μM, respectively); can be used both in cell culture and in vivo.

Petromyzonol is a tetrahydroxy stearol which serves as the primary spawning pheromone in adult sea lamprey. It is produced in the bile of sea lamprey larvae from the bile acid precursor allocholic acid. While the adult sea lamprey is relatively insensitive to petromyzonol itself, the C-24 sulfate...

Piriprost is a structural analog of PGI2 with low IP receptor-mediated activity. Piriprost inhibits 5-LO with an IC₅₀ value around 100 µM, as measured by the release of 5-HETE from cultured myometrial cells. Piriprost inhibits the release of histamine and leukotrienes from isolated...

A metabolic precursor of dopamine that crosses the blood brain barrier; used to treat Parkinson’s disease and stroke damage.

Antigen: purified glutathione S-transferase (S. japonicum) Host: rabbit Cross-reactivity: (+) GST and GST fusion proteins Application: WB and IP; other applications not tested (not intended for detection of mammalian GST)

A potent inhibitor of JAK2 that also inhibits the JAK2V617F mutant enzyme (IC₅₀s for both enzymes ~ 0.5 nM); orally bioavailable with a long half-life in vivo, suppressing leukemic cell spreading and splenomegaly in JAK2V617F cell-driven disease in mice.

An adenosine A2B receptor agonist (EC₅₀ = 3 nM for human A2B receptors) that displays selectivity over A1, A2A, and A3 receptors (EC₅₀s = >10 µM); used to study the role of the A2B receptor in regulating inflammation and mediating metabolic homeostasis.

Antigen: full length human TRF2 Host: mouse, clone 4A794.15 Isotype: IgG1κ Cross Reactivity: (+) human, mouse, muntjac, and rat TRF2 Application(s): ChIP, ELISA, FC (intracellular), ICC, IF, IHC (frozen sections and paraffin-embedded tissue), IP, and WB TRF2 is a ubiquitously expressed protein...

tert-butyl p-(bromomethyl) Benzoate is a synthetic intermediate useful for pharmaceutical synthesis.

γ-Linolenic acid is an ω-6 fatty acid which can be elongated to arachidonic acid for endogenous eicosanoid synthesis. It is a weak LTB4 receptor antagonist, inhibiting [3H]-LTB4 binding to porcine neutrophil membranes with a Ki of 1 µM. γ-Linolenic acid produces 53%...

A fluorogenic probe that acts as a substrate for specific cytochrome P450 (CYP) isoforms, including CYP3A4, CYP2C8, CYP2C9, CYP2C19, and aromatase (CYP19); used to detect changes in CYP catalytic activity caused by drugs or disease.

A highly ROS formed in vivo by the reaction of NO with superoxide; acts as a powerful oxidizing agent that can initiate lipid peroxidation, oxidize sulfhydryls, and nitrate the aromatic residues of proteins.

A synthetic analog of natural PtdIns containing C6:0 fatty acids at the sn-1 and sn-2 positions; contains the same inositol and DAG stereochemistry as that of the natural compound.

A natural anthocyanidin.

A non-nitrogenous bisphosphonate that inhibits hydroxyapatite crystal growth (IC₅₀ = 1.34 µM) and bone resorption; is cytotoxic to both osteoclasts and macrophages and has been used in biological research to selectively induce apoptosis of macrophage-like cells and cancer cells.

A methylated analog of SP 600125 that has much lower affinity for JNK isoforms (IC₅₀s = 18 and 24 µM for JNK2 and JNK3, respectively).

A synthetic cytokinin used as a media supplement to regulate growth in woody plant tissue cultures and micropropagations; concentrations below 1 µM promote axillary proliferation, whereas concentrations above 1 µM can stimulate the formation of callus, adventitious shoots, or somatic...

A phosphorylated aldohexose that can be used to produce glucose, mannitol, or N-glycans; also a ligand for both cation-dependent and -independent receptors and binds, as part of an N-glycan, to MRH domains on other proteins.

A fluorescent probe commonly used to identify dead cells; excitation at 488-535 nm and emission maximum of 617 nm.

An internal standard for the quantification of cannabidiol by GC- or LC-MS; intended for research and forensic applications.

Peptide Sequence: human monoacylglycerol lipase blocking peptide amino acids 1-14 (MPEESSPRRTPQSI) To be used in conjunction with Cayman’s Monoacylglycerol Lipase Polyclonal Antibody (Item No. 100035) to block protein-antibody complex formation during analysis for monoacylglycerol lipase.