Cayman Chemical

A mycotoxin which is cytotoxic against insect cells, killing the insect cell line SF-9 with a 50% cytotoxic concentration of 2.5 μM; induces apoptosis in mammalian cells with an IC50 value of 4.5 μM.

GW 590735 is a potent and selective agonist of peroxisome proliferator-activated receptor (PPAR)α with an EC50 value of 4 nM for the expression a GAL4-responsive reporter gene and at least 500-fold selectivity versus PPARγ and PPAR.delta..

Source: Recombinant N-terminal GST-tagged protein expressed in E. coli MW: 49.5 kDa RIZ1 is a SAM-dependent histone methyltransferase that specifically methylates histone H3 on lysine 9. RIZ1 is a tumor suppressor that can arrest the cell cycle and induce apoptosis.

An internal standard for the quantification of palmitic acid by GC- or LC-MS.

5-cis Carbaprostacyclin is a stable analog of PGI2 and an isomer of carbaprostacyclin. It is a weak inhibitor of human platelet aggregation with an IC₅₀ of 2.8 µM compared to 0.3 µM for carbaprostacyclin. 5-cis Carbaprostacyclin is a much weaker effector of rabbit mesenteric...

A selective, orally bioavailable inhibitor of EphB4 kinase autophosphorylation (ED₅₀ =25 nM); inhibits VEGF-directed vessel formation in an in vivo mouse model of angiogenesis.

A Ca2+-selective ionophore for biological membranes that can be used in microelectrodes for the determination of resting Ca2+-activities and of slowly changing Ca2+ levels.

8(S)-HETrE is a monohydroxy PUFA produced by rabbit neutrophil lipoxygenase when DGLA is used as a substrate. Although the biological activities of 8(S)-HETrE have not been well characterized, it is expected to behave similarly to 8(S)-HETE.

A cell-permeable inhibitor of the catalytic domain of SHP-1, SHP-1(ΔSH2) (Ki = 43 µM), and PTP1B (Ki = 42 µM).

An internal standard for the quantification of linoleoyl ethanolamide by GC- or LC-MS.

An internal standard for the quantification of misoprostol (free acid) by GC- or LC-MS.

A PARP inhibitor (IC₅₀ = 5 nM) with low affinity for the P-glycoprotein drug efflux transporter; induces a loss of p53 binding protein 1 expression in mice with KB1P tumors at 100 mg/kg.

A cyclic nitrone spin trap that can be used for the detection and characterization of thiyl radicals, hydroxyl radicals, and superoxide anions in vitro or in vivo.

An amide local anesthetic most commonly used in dentistry; it possesses a unique ester side chain that is metabolized rapidly by circulating esterases.

An unusual PUFA generated during the synthesis of docosahexaenoic acid-d5.

A competitive, non-NMDA glutamate receptor antagonist (IC₅₀s = 0.5 and 0.1 μM for AMPA and kainate receptors, respectively versus IC₅₀ = 40 μM for NMDA receptors); used to target AMPA and kainate receptor responses and thus differentiate from that of NMDA receptors.

An inhibitor of HDAC (IC₅₀ = 10 µM).

An NSAID that potently inhibits both COX-1 and COX-2 (IC₅₀s = 5 and 8 nM, respectively); used, in a variety of different formulations, as an analgesic.

Peptide affinity-purified IgG Immunogen: peptide from the internal region of MBOAT4 Host: rabbit Species Reactivity: (+) human Application(s): FC and IF

A c-Myc inhibitor that binds to and distorts the bHLH-ZIP domain of c-Myc (Kd = 2.8 µM), thereby inhibiting c-Myc/Max heterodimer formation and inhibiting its transcriptional activity (IC₅₀ = 146 µM); cytotoxic to c-Myc-overexpressing cells lines (IC₅₀s = 15.6 and...

An O-methylated anthocyanidin with antioxidant, antihypertensive, anti-inflammatory, and antiproliferative effects.

Immunogen: peptide from the N-terminal region of human Nrf-2 Host: rabbit Species Reactivity: (+) human, mouse, and rat Nrf2 Application(s): FC, ICC, and WB This N-terminal Nrf2 polyclonal antibody detects both poly-ubiquitinated Nrf2 at 90 kDa and native Nrf2 at 67 kDa. Nrf2 forms a heterodimer...

A long-acting ascorbic acid derivative that stimulates collagen expression and formation and is used in human cell culture; included in media to enhance the survival of human embryonic stem cells or drive osteogenic differentiation in human adipose stem cells and in human mesenchymal stromal/stem...

Caffeic acid is an inhibitor of 5-LO with an IC₅₀ value of 3.7-72 µM and 12-LO with an IC₅₀ value of 5.1-30 µM.