Cayman Chemical

A bpV compound that selectivity inhibits PTEN (IC₅₀ = 31 nM); also inhibits the vascular endothelial PTP, PTP-β (IC₅₀ = 12.7 μM), and PTP-1βB (IC₅₀ = 61 μM) and is known to be an insulin mimetic capable of activating the insulin receptor kinase.

A β3-adrenergic receptor agonist (EC₅₀ = 22.4 nM) that displays potent selectivity for β3 compared to the β1 and β2 receptor subtypes (EC₅₀s ≥ 10 µM); relaxes rat and human bladder strips precontracted with carbamoylcholine (EC₅₀s = 5.1...

An endocannabinoid analog specifically designed to be a potent and selective inhibitor of the cellular uptake of AEA; inhibits the cellular uptake of tritiated AEA (IC50 = 3 µM) in RBL-2H3 cells, with negligible effects on the CB1 receptor and TRPV1.

A non-polar glycopeptide antibiotic produced by A. teichomyceticus that is broadly effective against Gram-positive bacteria.

C-2 ceramide is a cell-permeable analog of naturally occurring ceramides. It mediates many diverse biological activities, as do natural ceramides. These processes include differentiation of HL-60 cells, induction of apoptosis, activation of protein phosphatase 2A, and inhibition of the mitochondrial...

A dual inhibitor of Cdks and Aurora kinases; inhibits Cdk1/cyclin B, Cdk2/cyclin A, Cdk2/cyclin E, Cdk3/cyclin E, Cdk4/cyclin D1, Cdk6/cyclin D1, Aurora A, and Aurora B in vitro (IC₅₀s = 9, 4, 3, 58, 253, 175, 11, and 15 nM, respectively); blocks the growth of cancer cells in vitro and in...

The parent CysLT produced by the LTC4 synthase-catalyzed conjugation of glutathione to LTA4; potent inducer of bronchoconstriction and enhanced vascular permeability that contributes to the pathogenesis of asthma and acute allergic hypersensitivity.

A potent and selective G9a HMTase inhibitor (IC50 = 6 nM; Ki = 63 pM); more than 40,000-fold selective for G9a over SET7/9, SET8, PRMT3, and JMJD2E.

An immune response modifier that acts as a ligand of TLR7 and 8; demonstrates potent anti-tumor and anti-viral properties and has been used to study the innate immune response to viral infections.

A selective dual inhibitor of mTORC1 and mTORC2.

A benzylisoquinoline that acts as a neuromuscular blocking agent with slow onset and intermediate duration; causes non-depolarizing block of the neuromuscular junction.

A fluorogenic substrate for human leukocyte and porcine pancreatic elastase; excitation: 355-380 nm; emission 440-460 nm.

An antibiotic derived from S. hygroscopicus that acts as a potassium ionophore promoting K+/H+ exchange across mitochondrial membranes; used as a research tool to disrupt intracellular H+ and K+ concentration, thus altering pH, membrane potential, and cell volume.

An inhibitor of PI3Kα that is selective for p110α in vitro (IC₅₀ = 15 nM for p110α vs. >1 µM for other isoforms, as well as for mTOR) and in cells when used at 1 µM.

A selective inhibitor of p38α MAPK (IC₅₀ = 10 nM) that blocks IL-1β and TNF-α release in whole blood in vitro (IC₅₀s = 150 and 180 nM, respectively).

A lipophilic, nontoxic, iron-chelating agent that shows high iron chelation efficacy both in vitro in cell culture models and also in vivo in rats and mice.

CAS Number: 792173-99-0 Molecular Formula: C₁₇H₁₃N₅O₂ Formula Weight: 319.3

An internal standard for the quantification of cannabidiol by GC- or LC-MS; intended for research and forensic applications.

A mycotoxin produced from F. moniliforme that functions as an inhibitor of ceramide synthase (sphingosine N-acyltransferase).

An N-substituted 1,8-naphthalimide used as a fluorescent probe for various studies and as a precursor for protection of amine groups.

A natural imidazole-containing dipeptide that has antioxidant activities in cells, particularly against lipid peroxidation.

A cell permeable inhibitor of necrosis that also demonstrates strong mitochondrial reactive oxygen species and ONOO- scavenging activity; localizes in mitochondria, selectively blocking oxidative stress-induced necrotic cell death (0.1 μM necrox-5 inhibited ~50% cell death in H9C2 cells exposed...

Quantification of lipid peroxidation is essential to assess the role of oxidative injury in pathophysiological disorders. Lipid peroxidation results in the formation of highly reactive, unstable hydroperoxides of both saturated and unsaturated lipids. Cayman’s Lipid Hydroperoxide Assay...

A mycotoxin produced by A. ochraceus, A. carbonarius, and P. verrucosum that is commonly found as a food contaminant (Tolerable Weekly Intake = 100 ng/kg body weight per day); triggers nephropathy, induces renal adenomas, and initiates skin tumors through events involving oxidative stress,...