Cayman Chemical

A colorimetric substrate for KIAA1363, a 2-acetyl monoacylglyceryl ether hydrolase critical to the survival and proliferation of many cancer cell lines.

A metabolite of PGI2; enhances intracellular cAMP and cholesterol catabolism in bovine arterial smooth muscle cells.

A potent, cell-permeable, and selective inhibitor of γ-secretase, blocking the cleavage of both APP and Notch CTFs with IC₅₀ values of ~0.3 nM; induces neuronal differentiation, impairs ovarian folliculogenesis, and suppresses thymocyte development by preventing Notch activation by...

A potent, selective, and orally active inhibitor of human mPGES-1 (IC₅₀ = 1.3 nM); potently inhibits guinea pig mPGES-1 (IC₅₀ = 0.9 nM) but not mouse or rat mPGES-1; prevents LPS-induced pyresis, hyperalgesia, and iodoacetate-induced osteoarthritic pain.

A potent inhibitor of hedgehog signaling that acts by directly antagonizing SMO (IC₅₀ = 20 nM); counteracts SMO activation by the SMO agonist SAG but only partially competes with SAG binding to SMO.

Cyclooxygenase metabolism of EPA to produce PGE3 has been reported in biosynthetic preparations of ovine seminal vesicles and in the ocular tissues of primates. PGA3 is an expected non-enzymatic dehydration product of this PGE3. PGA3 exhibits good affinity for the canine EP2 and EP4 receptors with...

A cyclic depsipeptide antibiotic that displays antitumor activity; acts as a bifunctional DNA intercalator that strongly binds DNA and forms crosslinks between DNA molecules; inhibits reverse transcriptases from HIV-1 and HIV-2 (IC₅₀s = 7 and 68 nM, respectively), as well as cellular DNA...

An inhibitor of respiration in animals and bacteria; binds at the quinone reduction site of succinate:ubiquinone oxidoreductase (SQR; Complex II) in animals, preventing ubiquinone from binding; inhibits NADH fumarate reductase in bacteria; inhibits photosystem II in plants.

A toxic antimetabolite for the tryptophan pathway in yeast that can be used to counterselect for TRP1, a commonly used genetic marker in S. cerevisiae.

An allosteric ligand of Fz4; inhibits nuclear translocation of β-catenin in U87MG glioma cells treated with lithium chloride; impairs the ability of U87MG cells to form neurospheres in culture and stimulates the differentiation of Caco-2 epithelial colorectal adenocarcinoma cells.

An NSAID that inhibits COX-2 activity with 1,000-fold selectivity over that of COX-1 (IC50s = 26 nM and > 50 µM in human osteosarcoma cells); effective against pain and inflammation in various rodent models.

An ester prodrug of melagatran, a potent, direct, and reversible thrombin inhibitor (Ki = 1.2 nM); used as an anticoagulant in a variety of situations.

A potent inhibitor of the generation of phosphatidic acid (IC₅₀ = 0.6 µM) from cytokine-activated lysophosphatidic acyl transferase (LPAAT), which has been shown to protect mice from endotoxic shock; suppresses the production of the proinflammatory cytokine IFN-γ, inhibits...

An analytical reference standard categorized as a phytocannabinoid; a bis-homolog of cannabidiol; intended for research and forensic applications

Antigen: synthetic peptide corresponding to human caspase-1 within the region of amino acids 371-390 Host: mouse, clone 14F468 Isotype: IgG1κ Cross Reactivity: (+) human and mouse caspase-1 Application(s): IHC (paraffin-embedded sections) and WB Caspase-1 is similar to the cell death gene...

A selective, positive allosteric modulator of mGluR2, stimulating the human and rat receptors with EC50 values of 33.2 and 96 nM, respectively; can be used on cells, tissues, or animals.

Induces the differentiation of human pluripotent stem cells, embryonic stem cells, or induced pluripotent stem cells to cardiomyocytes (10 μM) by inhibiting Wnt signaling.

A chromophoric substrate that is used to quantify inorganic phosphate (Pi) in the presence of purine nucleoside phosphorylase, followed by continuous spectrophotometry at an absorbance of 355-360 nm; used to measure changes in Pi levels in coupled enzyme systems.

A GSK3β inhibitor (Ki = 4.9 nM) that crosses the blood brain barrier and inhibits tau phosphorylation (IC₅₀ = 76 nM in vitro); stabilizes β-catenin and increases bone mass (via Wnt activation) in rats after a two-week treatment with a maximum effective oral dose of 20 mg/kg once...

An N-acetylglucosamine derivative that has been shown to promote hyaluronic acid production.

Blocks If currents through HCN channels in sinoatrial node cells (IC₅₀s = 1.83, 2.21, 1.9, and 1.88 µM, respectively for HCN1-4 in vitro); reduces heart rate from 600 to 200 beats per minute with an ED₅₀ value of 1.8 mg/kg and induces increasing arrhythmia at...

A derivative of cAMP that binds the PDE10 GAF domain (EC₅₀ = 40 μM) and has been used to study GAF-mediated stimulation of PDE10.

An enantiomer of C75, which in racemic form is a stable FAS inhibitor that when administered leads to profound weight loss and feeding inhibition in both high-fat diet wild type obese and leptin-deficient ob/ob mice.

A cell-permeable, selective adenylyl cyclase type V inhibitor (IC₅₀ = 8.3 μM in the presence of Gsα GTPγS-forskolin); tissue selective for the adenylyl cyclase catalytic activity in heart and lung tissues.