Cayman Chemical

A fluorogenic substrate for lysosomal acid lipase.

An acylated amino acid that is used as a urinary biomarker for several indications; increased urinary excretion is indicative of MCAD deficiency; can also be used as a biomarker for exposure to gamma radiation.

Antigen: purified recombinant Hsf1 protein Host: rat, clone 10H8 Cross Reactivity: (+) human, mouse, rat, bovine, guinea pig, hamster, monkey, and rabbit Hsf1 Applications: WB. IP, ICC, and EIA Isotype: IgG1

An internal standard for the quantification of latanoprost by GC- or LC-mass spectrometry (MS).

Antigen: human SIRT7 amino acids 35-51 and 361-377 Host: rabbit Cross Reactivity: (+) human SIRT7 Application(s): WB SIRT7 is a member of the sirtuin family of proteins, which are able to metabolize NAD+. Reports of histone-activated SIR2-mediated NAD+ metabolism and NAD+-activated SIR2-mediated...

Source: Recombinant N-terminal His- and SUMOpro-tagged protein expressed in E. coli Mr: 34.5 kDa

Product Description Leucinostatin A is a fungal metabolite originally isolated from P. lilacinus with diverse biological activities. 1 It is active against P. oryzae , B. cinera , P. chrysogenum , X. oryzae , S. cerevisiae , and C. albicans fungi and B. subtilis , S. aureus , S. lutea , and M. phlei...

Immunogen: Synthetic peptide from the C-terminal region of human SPT2 Host: Rabbit Species Reactivity: (+) Human, bovine, mouse, ovine, porcine, rat, African green monkey SPT2 Application(s): IHC and WB

A synthetic intermediate useful for pharmaceutical synthesis.

Antigen: full length human TRF2 Host: goat Cross Reactivity: human and mouse TRF2 Application(s): ChIP, ICC, IF, IHC, IP, and WB TRF2 is a ubiquitously expressed protein that is implicated in the control of telomere length.

A required cofactor for many enzymes including all NOS isoforms.

A pivotal molecule in the Krebs cycle, in the synthesis of fatty acids, and in isoprenoid-based protein modifications; serves as an intermediate in oxidation of fatty acids and amino acids; an essential cofactor or substrate for acetyltransferases and acyltransferases.

Biosynthesis of LTA3 occurs from 5,8,11-eicosatrienoic acid via the 5-LO pathway{689} and it is the putative intermediate in the biosynthesis of 3-series leukotrienes. LTA3 as a free acid is highly unstable. The methyl ester is stable and can be readily hydrolyzed to the free acid as needed.

Selective, cell-permeable ROCK inhibitor (effectively inhibits activity at 2 µM) that improves survival and reprogramming efficiency of iPSCs > 200 fold when used in combination with SB 431542 and PD0325091.

Follicle-Stimulating hormone (FSH) is a glycoprotein produced by the pituitary gland and consists of two subunits with an approximate total molecular mass of 35 kDa. In males, FSH acts on the Sertoli cells of the testis to stimulate the synthesis of androgen-binding protein, which is indirectly...

A potent, selective inhibitor of PKG (in vitro IC50 = 234 nM); cell-permeable and often used in intact cells to assess the role of PKG in signaling.

A cell-permeable, copper-containing 3-formylchromone derivative that inhibits Akt in an array of cancer cells (IC₅₀s = 10-34 µM); also causes NF-κB inactivation in an orthotopic pancreatic tumor model using COLO 357 cells.

Antigen: human PGT C-terminal amino acids 627-640 Host: rabbit Cross Reactivity: (+) human, mouse, rat, cow, and sheep PGT; expected to react with canine and chicken PGT Application(s): ICC, IF, and WB Transport of extracellular prostaglandins into cells occurs via a specific PG transporter (PGT).

(±)13-HODE is one of the two racemic monohydroxy fatty acids resulting from the non-enzymatic oxidation of linoleic acid. It is the principle hydroxylated fatty acid in human psoriatic skin scales, with a mean concentration of 17 ng/mg.

A cell-permeable, reversible inhibitor of Cdk1, showing preference for Cdk1/cyclin B1 (Ki = 35 nM) over Cdk1/cyclin A (Ki = 110 nM); also inhibits Cdk2 (Ki = 340 nM), PKCδ (Ki = 318 nM), and SGK (Ki = 497 nM) but not Cdk4; reversibly arrests proliferating cells at the G2/M phase border,...

A selective inhibitor of the nucleotide pool sanitizing enzyme MTH1 (IC₅₀ = 0.8 nM) that kills cancer cell lines (IC₅₀s = 0.8-3.06 µM).

An analog of ONO-4059, an orally bioavailable inhibitor of BTK (IC₅₀ = 2.2 nM) that reversibly blocks B cell receptor signaling and B cell proliferation and activation.

A tricyclic antidepressant that potently inhibits serotonin and norepinephrine reuptake (Kis = 7.4 and 96 nM, respectively); also an antagonist at histamine, muscarinic acetylcholine, α1-adrenergic, and dopamine receptors (Kds = 31, 37, 38, and 190 nM for H1, M1, α1, and D2,...

A component of the teicoplanin complex, a glycopeptide antibiotic produced by A. teichomyceticus that is broadly effective against Gram-positive bacteria.