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A potent, selective inhibitor of BMP1 (IC50 = 44 nM); effective in a cell-based model of collagen deposition is very effective at penetrating human skin in vitro.
13,14-dihydro-15(R)-PGE1 is an analog of 13,14-dihydro-PGE1, which has the hydroxyl group at C-15 in the unnatural R configuration.
An orally bioavailable prodrug of the second-generation proteasome inhibitor MLN2239, which inhibits the β5 chymotryptic-like subunit of the 20S proteasome (IC50 = 3.4 nM; Ki = 0.93 nM).
A LPA receptor antagonist with selectivity for LPA1 and LPA3; exhibits Ki values of 0.34, 6.5, and 0.93 µM for the human LPA1, LPA2, and LPA3 receptors, respectively.
A cell permeable, competitive inhibitor of HIF-PH with effective concentrations in the low µM range.
A 3-(benzylidne)indolin-2-one analog that selectively and potently inhibits Cdk2 (IC50 = 60 nM).
A Nampt inhibitor (IC50s = 3-6 nM) that prevents NAD+ synthesis from nicotinamide; inhibits the viability of multiple B-cell acute lymphoblastic leukemia cell lines with nanomolar potency and improves survival in an orthotopic xenotransplant model of high-risk acute lymphoblastic leukemia...
The racemic version of the selective NMDA receptor antagonist, D-AP5 that competitively inhibits the glutamate binding site of NMDA receptors (Kd = 1.4 μM); D-AP5 is the active (−)-stereoisomer, while L-AP5, the(+)-isomer, demonstrates considerably less potent NMDA receptor antagonist...
Blocks Tie2 kinase activity (Ki = 1.3 µM), inhibiting angiopoietin 1-induced Tie2 autophosphorylation and downstream signaling (IC50 = 0.3 µM); prevents endothelial cell tube formation and aberrant vessel growth in a rat model of Matrigel-induced choroidal neovascularization.
An inhibitor of CETP; inhibits plasma CETP with an IC50 value of 9 µM; in rabbits given an atherogenic diet, increases HDL, decreases VLDL, and attenuates induced atherosclerosis; in humans, inhibits CETP activity and increases HDL levels but does not reduce the risk of recurrent...
A cell-permeable triazine compound that inhibits the human E2 ubiquitin-conjugating enzyme Rad6B; selectively docks to the Rad6B catalytic site, inhibits Rad6B-induced histone H2A ubiquitination, downregulates intracellular β-catenin, induces G2/M arrest and apoptosis, and inhibits...
A selective agonist of GABAB (IC50 = 200 nM); causes skeletal muscle relaxation and blocks spasticity.
Antigen: human Trx1 peptide 84-105 Host: rabbit Application(s): ELISA, IHC, and WB Cross Reactivity: (−) Trx80
SREBP-2 is a transcription factor that performs a critical role in the transcriptional regulation of genes involved in cholesterol synthesis and uptake including HMG-CoA synthase, HMG-CoA reductase, and the LDL receptor.
Antigen: purified human recombinant PCSK9 Host: mouse, clone 15A6 Isotype: IgG1 Cross Reactivity: (+) human recombinant PCSK9 Application(s): PCSK9 ligand blotting (nondenaturing conditions) and WB PCSK9 is a member of the subtilisin serine protease family with an important role in lipoprotein...
An herbicide that is used to control a wide range of terrestrial and aquatic plants.
A major glycolipid produced from fermentation of sugar by yeasts that is used as a biosurfactant; possesses lower surface tension compared to the acid form of sophorolipids.
An internal standard for the quantification of 13-OxoODE by GC- or LC-MS.
A phytocannabinoid whose physiological and toxicological properties are not known
Arachidonoyl PAF C-16 is the product of acylation of lyso-PAF C-16 by a CoA-independent transacylase. It is the most common precursor for formation of PAF C-16 by the remodeling pathway.
ApNA is one of several nitroaniline fatty acid amides which can be used to measure FAAH activity. FAAH is a relatively unselective enzyme in that it accepts a variety of amide head groups other than the ethanolamine of its nominal endogenous substrate AEA (Item No. 90050). It also will hydrolyze...
A potent PR and GR antagonist with Ki value of approximately 1 nM.
Immunogen: thioredoxin fusion protein containing amino acids 34-76 of human adropin Host: rabbit Species Reactivity: (+) human adropin Application(s): ELISA and WB Adropin, encoded by the energy homeostasis associated gene, is involved in glucose homeostasis and lipid metabolism. It is involved in...
A potent and cell permeable PI3K inhibitor (IC50 = 11, 350, 18, and 58 nM for p110 subunit isoforms α, β, γ, and δ, respectively).