Cayman Chemical

An internal standard for the quantification of PGD2-EA by GC- or LC-MS.

5(S)-HpEPE is a monohydroperoxy PUFA produced by the action of 5-LO on EPA. It is metabolized to LTA5, a key intermediate in the formation of the 5-series leukotrienes. Alternatively, 5(S)-HpEPE is reduced to 5(S)-HEPE by peroxidases.

A potent inhibitor of the glycolysis enzyme PFKFB3, with an IC₅₀ value of 183 nM in vitro; avidly competes with F6P at PFKFB3 (Ki = 94 nM); cell permeable, inhibiting the growth of HeLa cells with a GI50 value of 2.7 µM.

A 25-carbon, fully saturated long-chain fatty acid.

A potent thrombin inhibitor (Ki = 4.5 nM); also inhibits trypsin (Ki = 50.3 nM), but only weakly inhibits other serine proteases; has poor bioavailability after oral administration.

Oxidized LDL (oxLDL) particles contain low molecular weight species which are cytotoxic and pro-atherogenic. Many of these substances were recently isolated and purified from oxLDL, and identified as phosphatidylcholine species containing a fragmented, oxidized short-chain fatty acid remnant at the...

A methyl ester version of the free acid that may act as a lipophilic prodrug form that will alter its distribution and pharmacokinetic properties.

Can be formed by the dimerization of two molecules of α-trans-cinnamic acid; significantly blocks inflammatory pain while having little effect on neurogenic pain, as indicated by the formalin test in mice.

A functionally selective inhibitor of Chk1 (Kd = 2 nM; IC₅₀ = 3 nM); interacts synergistically with DNA antimetabolite agents in vitro and in vivo to selectively induce double-strand DNA breaks and cell death in tumor cells.

A 16-membered macrolide antibiotic with anti-parasitic actions; effective against T. gondii in clinical trials.

A potent inhibitor of phosphatidic acid formation (IC50 = 0.6 µM) through cytokine-activated lysophosphatidic acyl transferase (LPAAT).

A monosialoganglioside that demonstrates both antiproliferative and antiangiogenic effects in tumor cells; dissociates the insulin receptor-caveolin-1 complex from lipid microdomains, functioning as an inhibitor of insulin signaling and contributing to insulin resistance.

methyl 4-Pyrimidine carboxylate is a synthetic intermediate useful for pharmaceutical synthesis.

Largely acts a cell signaling intermediate; serving as substrate to produce IP5s, which can be further phosphorylated to produce Ins(1,2,3,4,5,6-)P6; also phosphorylated to produce phytic acid, which serves diverse roles in eukaryotic tissues; a poor activator of the Ins(1,4,5)-P3 receptor in vitro.

Synonyms: SC0030

A sphingolipid degradation product that has been shown to induce cytoskeletal reorganization and eventual apoptosis via a JNK-dependent pathway; reacts readily with deoxyguanosine and DNA to form aldehyde-derived DNA adducts.

A certified reference material categorized as a phytocannabinoid; intended for research and forensic applications

Niflumic acid is a selective inhibitor of COX-2. The IC₅₀ values are 16 and 0.1 µM for human recombinant COX-1 and -2, respectively. The Ki values are 2 and 0.02 µM for ovine COX-1 and -2, respectively.

A selective inhibitor of Δ6 desaturase (IC50 = 0.2 µM in a rat liver microsomal assay) that completely blocks the conversion of linoleic acid to AA; orally active in vivo, decreasing edema in the carrageenan paw edema model in mice.

A selective CSF1R inhibitor (IC₅₀ = 1 nM) that inhibits CSF1-dependent proliferation (EC₅₀ = 67 nM in bone marrow-derived macrophages); blocks tumor progression and significantly improves survival in glioma-bearing mice as well as in mouse models of breast and cervical cancer.

A cell-permeable inhibitor of actin polymerization that has been shown to be 10 times less toxic in mice than cytochalasin D.

An alkaloid that inhibits the growth of mouse leukemia P388 cells (IC₅₀ = 1.8 μg/ml); binds to and stabilizes the topoisomerase I-DNA binary complex, leading to DNA breakage and cell death (IC₅₀ = 5.07-12.6 μM); selectively inhibits CYP1A1 and CYP1A2 (IC₅₀ = ~6...

A selective inhibitor of class I PI3K isoforms (IC₅₀s = 17, 53, and 6 nM for p110β, -γ, and -δ, respectively); orally bioavailable, showing strong antitumor activity against human cancer xenografts in mice.

A selective inhibitor of Ces3 (IC₅₀ = 1.94 µM) that has no significant effect on other, related enzymes; promotes lipid storage in cultured adipocytes and prevents basal lipolysis.