Cayman Chemical

An irreversible inhibitor of γ-glutamylcysteine synthetase (Ki limiting enzyme for GSH synthesis, that induces oxidative stress in cells by depleting GSH; enhances the toxicity of various chemotherapeutic agents in drug-resistant tumors.

A pan-RAR inverse agonist that blocks RARα activity with an IC₅₀ value of 114 nM; prevents the recruitment of transcriptional coactivators to RARs while stabilizing corepressor interactions.

A potent, bioavailable JAK inhibitor with preference for JAK2 (IC₅₀ = 2 nM) over JAK1 and JAK3 (IC₅₀s = 130 and 250 nM, respectively); effective against JAK2V617F as well as JAK2 and inhibits phosphorylation of STAT5 in vivo.

A benzothiazinone compound that selectively inhibits both MAO-B activity (IC₅₀ = 34.9 nM in human) and adenosine A2A receptors (Ki = 39.5 nM in human); designed as a potential dopamine-sparing therapeutic in the treatment of Parkinson’s disease.

A suicide inhibitor of LTB4 20-hydroxylase and renal CYP450 ω-hydroxylase.

Antigen: human 11β-HSD1 amino acids 78-92 (CLELGAASAHYIAGT) Host: rabbit Cross-reactivity: (+) human, mouse, and rat 11β-HSD1 Applications: IHC (formalin-fixed paraffin-embedded tissue) and WB 11β-HSD1 catalyzes the conversion of inactive cortisone to active cortisol in adipose...

A selective, potent, and cell-permeable inhibitor of mTOR (IC₅₀ = 4.3 nM) which blocks signaling through both mTORC1 and mTORC2; induces G1 cell cycle arrest in both rapamycin-sensitive and rapamycin-resistant cancer cell lines and reduces tumor growth in nude mice with PTEN-null tumors.

Long chain saturated fatty acids and their esters are common components of plant lipids. Methyl pentacosanoate is the methyl ester of the 25-carbon, fully saturated fatty acid pentacosanoic acid. This product is designed to be used as a standard in total fatty acid analysis.

A cell-permeable analog of cGMP that preferentially activates cGMP-dependent protein kinase; 1 µM-0.1 mM inhibits acetylcholine-induced increases in intracellular calcium concentrations.

Contains two streptogramin antibiotics, virginiamycin M1 (75%) and virginiamycin S1 (25%); irreversibly inhibits protein synthesis in bacteria; improves growth of livestock; used in fuel ethanol fermenters to prevent to control bacteria competing with yeast for nutrients.

A non-irritant bronchodilator with relaxant activity on human bronchial muscle; binds to the mouse recombinant EP3 and EP4 receptors with Ki values of 330 and 190 nM, respectively.

A potent antagonist of the dopamine receptors D2 and D3 (Ki = 2.8 and 3.2 nM, respectively, for the human receptors); also shown to be a potent antagonist of the serotonin receptors 5-HT2B and 5-HT7 (Ki = 13, 11.5 nM, respectively).

A nonpeptide renin inhibitor (IC₅₀ = 0.6 nM) that selectively binds to the S3 sub-pocket of renin, preventing the conversion of angiotensinogen to angiotensin I, thereby blocking eventual conversion to angiotensin II; reduces blood pressure in db/db mice.

NBI 31772 is a nonpeptide ligand that releases insulin-like growth factor-1 (IGF-1) from its binding protein (IGFBP; K_is = 1-24 nM for the six human subtypes of IGFBP). As the released IGF-1 is biologically active, NBI 31772 is used to assess the role of IGF-1 in cells and animals,...

A potent and selective agonist for the EP4 receptor (Ki = 0.7, 56, 620, and >10,000 nM for EP4, EP3, EP2, and EP1, respectively); promotes EP4-mediated bone formation, prevention of bone loss related to osteoporosis, osteoblast differentiation, and the stabilization of bone implants; supports...

EDTA stock solution (500 mM, pH 8.0) contains filtered EDTA (500 mM). It is ready to use as supplied.

A first generation tricyclic antidepressant that acts primarily as an inhibitor of serotonin and norepinephrine transporters (Kds = 1.4 and 37 nM, respectively); an antagonist at histamine, muscarinic acetylcholine, and α1-adrenergic receptors (Kd values are 37, 46, and 32 nM for H1, M1, and...

A green bile pigment produced from the oxidation of heme in a reaction catalyzed by heme oxygenase and further reduced to bilirubin by biliverdin reductase; possesses anti-mutagenic and antioxidant properties, scavenging free radicals.

An isomer of 17-phenyl trinor PGF2α, characterized by an inverted (β) hydroxyl group at C-15.

For measurement of LDH activity as an indicator of cell death.

A homolog of LOEA, characterized by the addition of an (R)-α-methyl group at the methylene carbon adjacent to the amide nitrogen.

A potent antioxidant that inhibits the oxidation of cholesterol in LDL and HDL by impairing the translocation of ABCA1 from intracellular compartments to the plasma membrane.

An internal standard for the quantification of 8-iso PGF2α by GC- or LC-MS.

Formal Name: 4-[[3-(trifluoromethyl)phenyl]methyl]-2H-1,4-benzothiazin-3(4H)-one CAS Number: 353262-04-1 Molecular Formula: C₁₆H₁₂F₃NOS