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A selective, negative allosteric modulator of the mGlu5 (IC50 = 61 nM; Ki = 477 nM); 10 μM results in a near complete blockade of the glutamate response in cortical astrocytes; 30 mg/kg in mice yields potent inhibition in a marble burying model of anxiety and is efficacious in an operant sensation seeking model of addiction.

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Thomas No.
C832M62
Mfr. No.
11995-1
Description
VU0360223-1 mg
CAS Number
1274859-33-4
Packaging Size
1 mg
Packaging Type
Bottle, Glass, Clear
list price/quantitytotal
$0.00
Thomas No.
C832M63
Mfr. No.
11995-5
Description
VU0360223-5 mg
CAS Number
1274859-33-4
Packaging Size
5 mg
Packaging Type
Bottle, Glass, Clear
list price/quantitytotal
$0.00
Thomas No.
C832M64
Mfr. No.
11995-10
Description
VU0360223-10 mg
CAS Number
1274859-33-4
Packaging Size
10 mg
Packaging Type
Bottle, Glass, Clear
list price/quantitytotal
$0.00
Thomas No.
C832M65
Mfr. No.
11995-50
Description
VU0360223-50 mg
CAS Number
1274859-33-4
Packaging Size
50 mg
Packaging Type
Bottle, Glass, Clear
list price/quantitytotal
$0.00
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