Cayman Chemical

Ascorbate (L-Ascorbic acid or Vitamin C) is a six-carbon lactone that is synthesized from glucose in the liver of most mammalian species, but not by humans who must obtain ascorbate through dietary consumption. In humans, ascorbate serves as an antioxidant and acts as an electron donor for various...

An α-glucosidase inhibitor (IC₅₀ = 5.6 µM) that delays the absorption and digestion of dietary polysaccharides by reversibly inhibiting digestive enzymes such as maltase, isomaltase, and sucrase (IC₅₀s = 0.18, 5.2, and 0.37 µM, respectively).

Antigen: phosphopeptide corresponding to amino acid residues surrounding the phospho-Ser778 of rat dynamin Host: sheep Cross-reactivity: (+) rat dynamin Application: WB

A naturally occurring naphthoquinine; increases glucose uptake by adipocytes and inhibits PTEN activity; inhibits glycolysis in cancer cells by inhibiting tumor-specific pyruvate kinase M2; inhibits leukocyte migration, downregulates chemokine receptor expression, and inhibits HIV-1 replication;...

Source: Recombinant human N-terminal GST-tagged protein expressed in E. coli amino acids 1,717-1,972 (N- and C-terminal truncation)

A process impurity associated with salbutamol sulfate.

A nonapeptide hormone primarily synthesized in the hypothalamus with roles in uterine contraction and lactation, social memory and attachment, sexual and maternal behavior, aggression, learning, anxiety, feeding, and pain perception.

A mycotoxin produced from Penicillium species that inhibits bacterial quorum sensing communication in P. aeruginosa; inhibits Fas-mediated apoptosis (100-200 μM) by targeting caspase-8 activity in Burkitt’s lymphoma Raji cells.

Antigen: peptide from the C-terminal region of human HIF-1α6 Host: rabbit Species Reactivity: (+) human, mouse, and simian HIF-1α Application(s): (+) WB HIF-1α is a transcription factor that accumulates under low-oxygen conditions. Following hypoxic stimulus and cytoplasmic...

Antigen: phosphopeptide corresponding to amino acid residues surrounding phospho-Thr34 of rat DARPP-32 Host: rabbit Cross Reactivity: (+) rat DARPP-32 Application(s): WB DARPP-32 is a dopamine and cAMP-regulated phosphoprotein that plays a critical role in the regulation of dopaminergic...

2-Methoxyestradiol (2-ME2) is a natural metabolite of estradiol with potent antitumor and antiangiogenic properties. 2-Methoxyestradiol is a natural metabolite of estradiol with potent antitumor and antiangiogenic properties. Cayman’s 2-Methoxyestradiol ELISA is a competitive assay that can be...

This goat anti-mouse (IgG+IgM) FITC is used as the 'secondary antibody' for immunofluorescent staining on tissues or culture cells where the primary antibody was generated in mice. It is highly recommended that proper negative controls, such as omitting the primary antibody, be included in...

A potent CYP3A4 inhibitor from grapefruit.

A reversible inhibitor of FAAH activity exhibiting an IC50 value of 1.3 µM.

A nonfixable red fluorescent dye (excitation max: 586 nm; emission max: 605 nm) that can be used as a specific marker for astrocytes and an activity-dependent probe for monitoring regulated exocytosis.

CAY10492 is a synthetic intermediate useful for pharmaceutical synthesis.

Antigen: human CysLT1 receptor C-terminal amino acids 318-337 Host: rabbit Cross Reactivity: (+) human CysLT1 receptor Application(s): FC, ICC, IHC (paraffin-embedded sections), and WB The CysLT1 receptor binds LTD4, LTC4, and LTE4, playing a major role in asthma by facillitating airway and...

A less active, chlorine-deficient analog of W-7, the potent calmodulin antagonist (Ki = 11 μM); suitable for use as a control compound for understanding the specificity of other calmodulin antagonists.

3-Bromo-7-nitroindazole is a more potent inhibitor of nNOS than 7-nitroindazole in vitro, but unlike 7-nitroindazole, it is also potent against iNOS. The IC₅₀ values for inhibition of rat nNOS, bovine eNOS, and rat iNOS are 0.17, 0.86, and 0.29 µM, respectively.

2-Pyrimidin-2-yl-propionic acid is a synthetic intermediate useful for pharmaceutical synthesis.

A selective inhibitor of Src kinases, including Src, Yes, Lyn, and Fyn (IC₅₀ = 280, 20, 130, and 170 nM, respectively).

Ins(1,4,5)P3 is a second messenger produced in cells by PLC mediated hydrolysis of phosphatidyl inositol-4,5-biphosphate. It binds to one of several Ins(1,4,5)P3 receptors, each containing a calcium channel domain. Binding of Ins(1,4,5)P3 to the receptor results in opening of the calcium channels...

A long-chain ω-6 fatty acid with a hydroxyethylamide group attached at the alpha chain.

A synthetic intermediate useful for pharmaceutical synthesis.